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Non-Neoplastic Tonsillar Disorder

MedGen UID:
1751548
•Concept ID:
C5420390
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the tonsils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Tonsillar Disorder

Recent clinical studies

Etiology

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.
Brown RE, Zhang PL, Lun M, Zhu S, Pellitteri PK, Riefkohl W, Law A, Wood GC, Kennedy TL
Ann Clin Lab Sci 2006 Summer;36(3):273-82. PMID: 16951268
Mucosal mantle cell (centrocytic) lymphomas.
Fraga M, Lloret E, Sanchez-Verde L, Orradre JL, Campo E, Bosch F, Piris MA
Histopathology 1995 May;26(5):413-22. doi: 10.1111/j.1365-2559.1995.tb00248.x. PMID: 7657310

Diagnosis

Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B).
Murphy D, Parker J, Zhou M, Fadlelmola FM, Steidl C, Karsan A, Gascoyne RD, Chen H, Banerjee D
Mol Cancer 2010 Jan 26;9:14. doi: 10.1186/1476-4598-9-14. PMID: 20100355Free PMC Article
Expression of glucocorticoid receptors in non-neoplastic lymphoid follicles and B cell type malignant lymphomas.
Okazaki SI, Yamakawa M, Maeda K, Ohta N, Aoyagi M
J Clin Pathol 2006 Apr;59(4):410-6. Epub 2006 Feb 6 doi: 10.1136/jcp.2005.025858. PMID: 16461807Free PMC Article
The bcl-2/JH gene rearrangement is undetectable in Hodgkin's lymphomas: results from the German Hodgkin trial.
Nolte M, Werner M, Spann W, Schnabel B, von Wasielewski R, Wilkens L, Hübner K, Fischer R, Georgii A
Virchows Arch 1995;426(1):37-41. doi: 10.1007/BF00194696. PMID: 7704322
Lymphoid papillary hyperplasia of the palatine tonsils.
Carrillo-Farga J, Abbud-Neme F, Deutsch E
Am J Surg Pathol 1983 Sep;7(6):579-82. doi: 10.1097/00000478-198309000-00008. PMID: 6625051

Therapy

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.
Brown RE, Zhang PL, Lun M, Zhu S, Pellitteri PK, Riefkohl W, Law A, Wood GC, Kennedy TL
Ann Clin Lab Sci 2006 Summer;36(3):273-82. PMID: 16951268

Prognosis

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.
Brown RE, Zhang PL, Lun M, Zhu S, Pellitteri PK, Riefkohl W, Law A, Wood GC, Kennedy TL
Ann Clin Lab Sci 2006 Summer;36(3):273-82. PMID: 16951268
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Zhang PL, Pellitteri PK, Law A, Gilroy PA, Wood GC, Kennedy TL, Blasick TM, Lun M, Schuerch C 3rd, Brown RE
Mod Pathol 2005 Jul;18(7):924-32. doi: 10.1038/modpathol.3800372. PMID: 15920558

Clinical prediction guides

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.
Brown RE, Zhang PL, Lun M, Zhu S, Pellitteri PK, Riefkohl W, Law A, Wood GC, Kennedy TL
Ann Clin Lab Sci 2006 Summer;36(3):273-82. PMID: 16951268
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Zhang PL, Pellitteri PK, Law A, Gilroy PA, Wood GC, Kennedy TL, Blasick TM, Lun M, Schuerch C 3rd, Brown RE
Mod Pathol 2005 Jul;18(7):924-32. doi: 10.1038/modpathol.3800372. PMID: 15920558
Detection of Epstein-Barr virus infection in the epithelial cells and lymphocytes of non-neoplastic tonsils by in situ hybridization and in situ PCR.
Kobayashi R, Takeuchi H, Sasaki M, Hasegawa M, Hirai K
Arch Virol 1998;143(4):803-13. doi: 10.1007/s007050050332. PMID: 9638150
Mucosal mantle cell (centrocytic) lymphomas.
Fraga M, Lloret E, Sanchez-Verde L, Orradre JL, Campo E, Bosch F, Piris MA
Histopathology 1995 May;26(5):413-22. doi: 10.1111/j.1365-2559.1995.tb00248.x. PMID: 7657310
Immunoreactivity of neoplastic and non-neoplastic monocytoid B lymphocytes for DBA.44 and other antibodies.
Ohsawa M, Kanno H, Machii T, Aozasa K
J Clin Pathol 1994 Oct;47(10):928-32. doi: 10.1136/jcp.47.10.928. PMID: 7962607Free PMC Article

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