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Benign muscle neoplasm

MedGen UID:: 10236
•Concept ID:: C0027086
•: Neoplastic Process

Synonyms:	Myoma; Myomas
SNOMED CT:	Benign tumor of muscle (92237006); Benign neoplasm of muscle (92237006); Myoma (1156875002)

HPO:	HP:0031460
Monarch Initiative:	MONDO:0003061

Definition

A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue [NCIT:C4882]. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign muscle neoplasm

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign connective and soft tissue neoplasm
        Benign soft tissue neoplasm
        Benign muscle neoplasm
        Benign Skeletal Muscle Neoplasm
        Extracardiac Rhabdomyoma
        Adult Extracardiac Rhabdomyoma
        Central Nervous System Rhabdomyoma
        Fetal Rhabdomyoma
        Genital Rhabdomyoma
        Mediastinal Rhabdomyoma
        Paratesticular Rhabdomyoma
        Benign smooth muscle neoplasm
        Leiomyoma
        Angioleiomyoma
        Bizarre leiomyoma
        Bladder leiomyoma
        Bone Leiomyoma
        Breast leiomyoma
        Cellular leiomyoma
        Central nervous system leiomyoma
        Cervical Leiomyoma
        Cutaneous leiomyoma
        Deep leiomyoma
        Digestive System Leiomyoma
        Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Fallopian tube leiomyoma
        Laryngeal leiomyoma
        Leiomyoma of ciliary body
        Leiomyomatosis
        Lung leiomyoma
        Mediastinum leiomyoma
        Myxoid Leiomyoma
        Oral Cavity Leiomyoma
        Ovarian Leiomyoma
        Paratesticular Leiomyoma
        Penile Leiomyoma
        Pericardium leiomyoma
        Prostate leiomyoma
        Renal leiomyoma
        Sinonasal Leiomyoma
        Thyroid Gland Leiomyoma
        Trachea leiomyoma
        Ureter leiomyoma
        Urethra leiomyoma
        Uterine leiomyoma
        Uterine Ligament Leiomyoma
        Vaginal leiomyoma
        Vulvar leiomyoma
        Infiltrating lipoma
        Infiltrating Intramuscular Lipoma
        Intramuscular Myxoma
        Cellular Myxoma
        Rhabdomyoma
        Cardiac rhabdomyoma
        Adult Cardiac Cellular Rhabdomyoma
        Conventional Cardiac Rhabdomyoma

Professional guidelines

PubMed

Uterine fibroid-related infertility: mechanisms and management.

Donnez J, Taylor HS, Marcellin L, Dolmans MM
Fertil Steril 2024 Jul;122(1):31-39. Epub 2024 Mar 5 doi: 10.1016/j.fertnstert.2024.02.049. PMID: 38453041

Non-surgical Management of Myomas.

Laughlin-Tommaso SK
J Minim Invasive Gynecol 2018 Feb;25(2):229-236. Epub 2017 Aug 15 doi: 10.1016/j.jmig.2017.08.642. PMID: 28821471

The management of uterine leiomyomas.

Vilos GA, Allaire C, Laberge PY, Leyland N; SPECIAL CONTRIBUTORS
J Obstet Gynaecol Can 2015 Feb;37(2):157-178. doi: 10.1016/S1701-2163(15)30338-8. PMID: 25767949

See all (199)

Recent clinical studies

Etiology

Uterine Myomas: Extravascular Treatment.

Ierardi AM, Carnevale A, Pellegrino F, Stefano GD, Bonelli C, Renzulli M, Giganti M, Carrafiello G
Semin Ultrasound CT MR 2021 Feb;42(1):56-74. Epub 2020 Aug 29 doi: 10.1053/j.sult.2020.08.004. PMID: 33541590

Prevention and Management of Complications in Laparoscopic Myomectomy.

Tanos V, Berry KE, Frist M, Campo R, DeWilde RL
Biomed Res Int 2018;2018:8250952. Epub 2018 Mar 5 doi: 10.1155/2018/8250952. PMID: 29693017 Free PMC Article

Pathology of eyelid tumors.

Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927 Free PMC Article

Cardiac tumors.

Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689

Imaging for uterine myomas and adenomyosis.

Shwayder J, Sakhel K
J Minim Invasive Gynecol 2014 May-Jun;21(3):362-76. Epub 2013 Dec 4 doi: 10.1016/j.jmig.2013.11.011. PMID: 24316138

See all (1773)

Diagnosis

Uterine Myomas: Extravascular Treatment.

Uterine Myomas: Endovascular Treatment.

Contegiacomo A, Cina A, Di Stasi C, Barone M, Scrofani AR, Barbieri P, Punzi E, Manfredi R
Semin Ultrasound CT MR 2021 Feb;42(1):13-24. Epub 2020 Jul 15 doi: 10.1053/j.sult.2020.07.002. PMID: 33541585

Prolapsed cervical myoma during pregnancy.

González González V, Herráez Moreta A, Mayoral Triana A, Riolobos Sierra L, Cristóbal García I, Izquierdo Méndez N
Eur J Obstet Gynecol Reprod Biol 2020 Sep;252:150-154. Epub 2020 Jun 24 doi: 10.1016/j.ejogrb.2020.06.039. PMID: 32619878

Extracardiac rhabdomyomas.

Willis J, Abdul-Karim FW, di Sant'Agnese PA
Semin Diagn Pathol 1994 Feb;11(1):15-25. PMID: 8202643

Laparoscopy.

Wheeless CR Jr
Clin Obstet Gynecol 1976 Jun;19(2):277-98. doi: 10.1097/00003081-197606000-00004. PMID: 132320

See all (2378)

Therapy

Radiofrequency Ablation of Uterine Myomas and Pregnancy Outcomes: An Updated Review of the Literature.

Polin M, Hur HC
J Minim Invasive Gynecol 2022 Jun;29(6):709-715. Epub 2022 Feb 2 doi: 10.1016/j.jmig.2022.01.015. PMID: 35123041

Uterine Myomas: Endovascular Treatment.

Uterine Fibroids and Diet.

Tinelli A, Vinciguerra M, Malvasi A, Andjić M, Babović I, Sparić R
Int J Environ Res Public Health 2021 Jan 25;18(3) doi: 10.3390/ijerph18031066. PMID: 33504114 Free PMC Article

Urinary biomarkers in bladder cancer: A review of the current landscape and future directions.

Ng K, Stenzl A, Sharma A, Vasdev N
Urol Oncol 2021 Jan;39(1):41-51. Epub 2020 Sep 9 doi: 10.1016/j.urolonc.2020.08.016. PMID: 32919875

Prevention and Management of Complications in Laparoscopic Myomectomy.

Tanos V, Berry KE, Frist M, Campo R, DeWilde RL
Biomed Res Int 2018;2018:8250952. Epub 2018 Mar 5 doi: 10.1155/2018/8250952. PMID: 29693017 Free PMC Article

See all (993)

Prognosis

Diagnostic considerations and surgical techniques for a large prolapsing submucosal myoma.

Carey-Love A, Bradley L, Kho RM
Fertil Steril 2023 Oct;120(4):920-921. Epub 2023 Jul 23 doi: 10.1016/j.fertnstert.2023.07.009. PMID: 37487820

Prolapsed cervical myoma during pregnancy.

Cardiac tumors.

Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689

Cardiac tumours in infancy.

Yadava OP
Indian Heart J 2012 Sep-Oct;64(5):492-6. Epub 2012 Jun 23 doi: 10.1016/j.ihj.2012.05.004. PMID: 23102388 Free PMC Article

Intraosseous hemangiomas.

Valentini V, Nicolai G, Lorè B, Aboh IV
J Craniofac Surg 2008 Nov;19(6):1459-64. doi: 10.1097/SCS.0b013e318188a030. PMID: 19098533

See all (1061)

Clinical prediction guides

Oral Adult Rhabdomyoma.

da Silva Leonel ACL, Dos Santos ST, de Amorim Carvalho EJ, de Castro JFL, de Almeida OP, da Cruz Perez DE
Head Neck Pathol 2021 Dec;15(4):1253-1260. Epub 2021 Aug 10 doi: 10.1007/s12105-021-01371-z. PMID: 34378165 Free PMC Article

Uterine Myomas: Focused Ultrasound Surgery.

Napoli A, Alfieri G, Andrani F, Scipione R, Manganaro L, Pecorini F, Catalano C
Semin Ultrasound CT MR 2021 Feb;42(1):25-36. Epub 2020 Aug 21 doi: 10.1053/j.sult.2020.08.001. PMID: 33541586

Uterine Fibroids and Diet.

Tinelli A, Vinciguerra M, Malvasi A, Andjić M, Babović I, Sparić R
Int J Environ Res Public Health 2021 Jan 25;18(3) doi: 10.3390/ijerph18031066. PMID: 33504114 Free PMC Article

Urinary biomarkers in bladder cancer: A review of the current landscape and future directions.

Ng K, Stenzl A, Sharma A, Vasdev N
Urol Oncol 2021 Jan;39(1):41-51. Epub 2020 Sep 9 doi: 10.1016/j.urolonc.2020.08.016. PMID: 32919875

Cutaneous myofibroma.

Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

See all (1021)

Recent systematic reviews

Robotic-assisted laparoscopic versus abdominal and laparoscopic myomectomy: A systematic review and meta-analysis.

Chen W, Ma J, Yang Z, Han X, Hu C, Wang H, Peng Y, Zhang L, Jiang B
Int J Gynaecol Obstet 2024 Sep;166(3):994-1005. Epub 2024 Apr 8 doi: 10.1002/ijgo.15485. PMID: 38588036

The effect of ≤6 cm sized noncavity-distorting intramural fibroids on in vitro fertilization outcomes: a systematic review and meta-analysis.

Erden M, Uyanik E, Polat M, Ozbek IY, Yarali H, Mumusoglu S
Fertil Steril 2023 Jun;119(6):996-1007. Epub 2023 Feb 21 doi: 10.1016/j.fertnstert.2023.02.018. PMID: 36813123

Radiofrequency Ablation of Uterine Myomas and Pregnancy Outcomes: An Updated Review of the Literature.

Polin M, Hur HC
J Minim Invasive Gynecol 2022 Jun;29(6):709-715. Epub 2022 Feb 2 doi: 10.1016/j.jmig.2022.01.015. PMID: 35123041

Fibroids and natural fertility: a systematic review and meta-analysis.

Somigliana E, Reschini M, Bonanni V, Busnelli A, Li Piani L, Vercellini P
Reprod Biomed Online 2021 Jul;43(1):100-110. Epub 2021 Mar 23 doi: 10.1016/j.rbmo.2021.03.013. PMID: 33903032

Cigarette smoking and risk of uterine myoma: systematic review and meta-analysis.

Chiaffarino F, Ricci E, Cipriani S, Chiantera V, Parazzini F
Eur J Obstet Gynecol Reprod Biol 2016 Feb;197:63-71. Epub 2015 Nov 25 doi: 10.1016/j.ejogrb.2015.11.023. PMID: 26706924

See all (58)

MedGen

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Benign muscle neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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