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Subacute cutaneous lupus erythematosus

MedGen UID:
7403
•Concept ID:
C0024140
•
Disease or Syndrome
Synonyms: Lupus Erythematosus, Cutaneous, Subacute; Lupus Erythematosus, Subacute Cutaneous
SNOMED CT: Subacute cutaneous lupus erythematosus (239891002); SCLE - Subacute cutaneous lupus erythematosus (239891002); SACLE - Subacute cutaneous lupus erythematosus (239891002)
 
Monarch Initiative: MONDO:0015573
Orphanet: ORPHA163525

Definition

A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubacute cutaneous lupus erythematosus
Follow this link to review classifications for Subacute cutaneous lupus erythematosus in Orphanet.

Professional guidelines

PubMed

Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.
Bao A, Petri MA, Fava A, Kang J
Lupus Sci Med 2023 Dec 19;10(2) doi: 10.1136/lupus-2023-001007. PMID: 38114267Free PMC Article
Recognition and Management of Cutaneous Connective Tissue Diseases.
Kus KJB, LaChance AH, Vleugels RA
Med Clin North Am 2021 Jul;105(4):757-782. doi: 10.1016/j.mcna.2021.04.011. PMID: 34059249
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.
Heinly B, Allenzara A, Helm M, Foulke GT
Drugs Aging 2024 Jan;41(1):31-43. Epub 2023 Nov 22 doi: 10.1007/s40266-023-01079-5. PMID: 37991658
Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013

Diagnosis

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Annular lichenoid diseases.
McNally MA, Farooq S, Brown AE, Rees A, Hsu S, Motaparthi K
Clin Dermatol 2022 Sep-Oct;40(5):466-479. Epub 2021 Dec 31 doi: 10.1016/j.clindermatol.2021.12.009. PMID: 34979268
Mimics of Dermatitis.
Bailiff OA, Mowad CM
Immunol Allergy Clin North Am 2021 Aug;41(3):493-515. doi: 10.1016/j.iac.2021.04.009. PMID: 34225903
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Therapy

Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.
Bao A, Petri MA, Fava A, Kang J
Lupus Sci Med 2023 Dec 19;10(2) doi: 10.1136/lupus-2023-001007. PMID: 38114267Free PMC Article
Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Deucravacitinib in moderate-to-severe psoriasis.
Vu A, Maloney V, Gordon KB
Immunotherapy 2022 Nov;14(16):1279-1290. Epub 2022 Nov 14 doi: 10.2217/imt-2022-0109. PMID: 36373503
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article
An update in drug-induced subacute cutaneous lupus erythematosus.
Michaelis TC, Sontheimer RD, Lowe GC
Dermatol Online J 2017 Mar 15;23(3) PMID: 28329511

Prognosis

Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Proton pump inhibitor induced subacute cutaneous lupus erythematosus: Clinical characteristics and outcomes.
Poh YJ, Alrashid A, Sangle SR, Higgins E, Benton E, McGibbon D, D'Cruz DP
Lupus 2022 Aug;31(9):1078-1083. Epub 2022 May 30 doi: 10.1177/09612033221104237. PMID: 35635045
Subacute cutaneous lupus erythematosus.
Furzeland J, Malcolm P
J R Army Med Corps 2017 Apr;163(2):149-151. Epub 2016 Jun 9 doi: 10.1136/jramc-2015-000566. PMID: 27286780
Systemic lupus erythematosus.
Pearce L
Nurs Stand 2016 Jun 22;30(43):17. doi: 10.7748/ns.30.43.17.s21. PMID: 27332581
Lupus erythematosus in childhood.
Lee LA, Weston WL
Dermatol Clin 1986 Jan;4(1):151-60. PMID: 3521977

Clinical prediction guides

Deucravacitinib in moderate-to-severe psoriasis.
Vu A, Maloney V, Gordon KB
Immunotherapy 2022 Nov;14(16):1279-1290. Epub 2022 Nov 14 doi: 10.2217/imt-2022-0109. PMID: 36373503
Proton pump inhibitors-related subacute cutaneous lupus erythematosus: Clinical characteristics, management, and outcome.
Deng Z, Guo A, Wu C, Wang C
J Cosmet Dermatol 2022 Dec;21(12):7202-7208. Epub 2022 Oct 31 doi: 10.1111/jocd.15450. PMID: 36214602
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013
Subacute cutaneous lupus erythematosus.
David-Bajar KM
J Invest Dermatol 1993 Jan;100(1):2S-8S. doi: 10.1111/1523-1747.ep12355164. PMID: 8423385

Recent systematic reviews

COVID-19 and exacerbation of dermatological diseases: A review of the available literature.
Aram K, Patil A, Goldust M, Rajabi F
Dermatol Ther 2021 Nov;34(6):e15113. Epub 2021 Sep 7 doi: 10.1111/dth.15113. PMID: 34453380Free PMC Article
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, Ellis S, Clarke A, Wace H, Martin B, Smith J
Drugs R D 2020 Dec;20(4):319-330. doi: 10.1007/s40268-020-00320-5. PMID: 32960413Free PMC Article
Cutaneous effects of antihypertensive drugs.
Baccino D, Merlo G, Cozzani E, Rosa GM, Tini G, Burlando M, Parodi A
G Ital Dermatol Venereol 2020 Apr;155(2):202-211. Epub 2019 Jun 12 doi: 10.23736/S0392-0488.19.06360-0. PMID: 31195782
A systematic review of drug-induced subacute cutaneous lupus erythematosus.
Lowe GC, Henderson CL, Grau RH, Hansen CB, Sontheimer RD
Br J Dermatol 2011 Mar;164(3):465-72. Epub 2011 Feb 17 doi: 10.1111/j.1365-2133.2010.10110.x. PMID: 21039412
Lupus erythematosus and other autoimmune diseases related to statin therapy: a systematic review.
Noël B
J Eur Acad Dermatol Venereol 2007 Jan;21(1):17-24. doi: 10.1111/j.1468-3083.2006.01838.x. PMID: 17207162

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