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Leiomyoma

MedGen UID:
9710
Concept ID:
C0023267
Neoplastic Process
Synonyms: Fibroid; Fibroid Tumor; Fibroid Tumors; Fibroids; Fibromyoma; Fibromyomas; Leiomyomas; Tumor, Fibroid; Tumors, Fibroid
SNOMED CT: Fibromyoma (1162890002); Leiomyofibroma (1162890002); Plexiform leiomyoma (1162890002); Fibroleiomyoma (1162890002); Fibroid (1162890002); Leiomyoma (1162890002); Soft tissue tumor of smooth muscle differentiation (1187125003); Leiomyomatous neoplasm (1187125003)
 
Monarch Initiative: MONDO:0001572

Definition

A well-circumscribed benign smooth muscle neoplasm characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyoma

Professional guidelines

PubMed

Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Wei JJ
Semin Diagn Pathol 2022 May;39(3):187-200. Epub 2022 Feb 2 doi: 10.1053/j.semdp.2022.01.006. PMID: 35144823Free PMC Article
Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:3-11. Epub 2017 Oct 1 doi: 10.1016/j.bpobgyn.2017.09.004. PMID: 29054502
Laughlin-Tommaso SK
J Minim Invasive Gynecol 2018 Feb;25(2):229-236. Epub 2017 Aug 15 doi: 10.1016/j.jmig.2017.08.642. PMID: 28821471
McWilliams MM, Chennathukuzhi VM
Semin Reprod Med 2017 Mar;35(2):181-189. Epub 2017 Mar 9 doi: 10.1055/s-0037-1599090. PMID: 28278535Free PMC Article
Lethaby A, Vollenhoven B
BMJ Clin Evid 2015 Jun 2;2015 PMID: 26032466Free PMC Article

Diagnosis

Alashqar A, El Ouweini H, Gornet M, Yenokyan G, Borahay MA
Minerva Obstet Gynecol 2023 Feb;75(1):27-38. Epub 2022 Mar 25 doi: 10.23736/S2724-606X.22.04952-1. PMID: 35333033
Long M, Hu XL, Zhao G, Liu Y, Hu T
BMC Womens Health 2022 Apr 14;22(1):119. doi: 10.1186/s12905-022-01700-6. PMID: 35421983Free PMC Article
Bangash M, Faruqui N, Muhammad AU, Uddin Z
J Ayub Med Coll Abbottabad 2021 Oct-Dec;33(4):685-689. PMID: 35124930
Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479
Preda F, Alloisio M, Lequaglie C, Ongari M, Ravasi G
Tumori 1986 Oct 31;72(5):503-6. doi: 10.1177/030089168607200509. PMID: 3798572

Therapy

Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Lonnerfors C
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:113-119. Epub 2017 Sep 29 doi: 10.1016/j.bpobgyn.2017.09.005. PMID: 29103894
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Yuan H, Zhang S
Arch Gynecol Obstet 2019 Jan;299(1):47-53. Epub 2018 Dec 5 doi: 10.1007/s00404-018-4991-2. PMID: 30519753
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912

Clinical prediction guides

Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Melo DG, Jallad PSS, Brito LGO
Rev Bras Ginecol Obstet 2018 Sep;40(9):547-553. Epub 2018 Sep 19 doi: 10.1055/s-0038-1672163. PMID: 30231291Free PMC Article
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Patil PA, McKenney JK, Trpkov K, Hes O, Montironi R, Scarpelli M, Nesi G, Aron M, Sangoi AR, Gattuso P, Magi-Galluzzi C
Am J Surg Pathol 2015 Mar;39(3):349-56. doi: 10.1097/PAS.0000000000000354. PMID: 25517956
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article

Recent systematic reviews

Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489Free PMC Article
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Polin M, Hur HC
J Minim Invasive Gynecol 2022 Jun;29(6):709-715. Epub 2022 Feb 2 doi: 10.1016/j.jmig.2022.01.015. PMID: 35123041
Somigliana E, Reschini M, Bonanni V, Busnelli A, Li Piani L, Vercellini P
Reprod Biomed Online 2021 Jul;43(1):100-110. Epub 2021 Mar 23 doi: 10.1016/j.rbmo.2021.03.013. PMID: 33903032
Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R
BJOG 2017 Sep;124(10):1501-1512. Epub 2017 May 13 doi: 10.1111/1471-0528.14640. PMID: 28296146

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