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Hypolipoproteinemia

MedGen UID:
6982
•Concept ID:
C0020623
•
Finding; Finding
Synonym: Hypolipoproteinemia (disease)
SNOMED CT: Lipoprotein deficiency disorder (267436001); Hypolipoproteinemia (363140000)
 
HPO: HP:0010981
Monarch Initiative: MONDO:0001822

Definition

An abnormal decrease in the level of lipoprotein cholesterol in the blood. [from HPO]

Professional guidelines

PubMed

Detection of dyslipoproteinemia with the use of plasma total cholesterol and triglyceride as screening tests. The Lipid Research Clinics Program Prevalence Study.
Kwiterovich PO Jr, Stewart P, Probstfield JL, Stinnett S, Chambless LE, Chase GA, Jacobs DR, Morrison JA
Circulation 1986 Jan;73(1 Pt 2):I30-9. PMID: 3940681

Recent clinical studies

Etiology

Association Between Blood Lipid Profiles and Atrial Fibrillation: A Case-Control Study.
Li ZZ, Du X, Guo XY, Tang RB, Jiang C, Liu N, Chang SS, Yu RH, Long DY, Bai R, Sang CH, Li SN, Dong JZ, Ma CS
Med Sci Monit 2018 Jun 9;24:3903-3908. doi: 10.12659/MSM.907580. PMID: 29885277Free PMC Article
Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis.
Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, Lee MS, Tsai MH
Crit Care 2015 Mar 17;19(1):88. doi: 10.1186/s13054-015-0832-x. PMID: 25851781Free PMC Article
Significant association between hypolipoproteinemia(a) and lifetime risk of cancer: an autopsy study from a community-based Geriatric Hospital.
Mieno MN, Sawabe M, Tanaka N, Nakahara K, Hamamatsu A, Chida K, Sakurai U, Arai T, Harada K, Mori S, Inamatsu T, Ozawa T, Honma N, Aida J, Takubo K, Matsushita S
Cancer Epidemiol 2014 Oct;38(5):550-5. Epub 2014 Aug 19 doi: 10.1016/j.canep.2014.07.013. PMID: 25164551
Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients.
Venetsanou K, Vlachos K, Moles A, Fragakis G, Fildissis G, Baltopoulos G
Eur Cytokine Netw 2007 Dec;18(4):206-9. Epub 2007 Nov 12 doi: 10.1684/ecn.2007.0112. PMID: 17993453
Risks for hyperlipidemia.
Nestruck AC, Davignon J
Cardiol Clin 1986 Feb;4(1):47-56. PMID: 2871933

Diagnosis

Familial ApoB-specific familial hypobetalipoproteinemia in a patient with non-classical congenital adrenal hyperplasia.
Ramos Bachiller B, Luque-Ramírez M, Rodríguez-Jiménez C, Arrieta Blanco FJ
Clin Investig Arterioscler 2024 May-Jun;36(3):128-132. Epub 2024 Jan 8 doi: 10.1016/j.arteri.2023.12.002. PMID: 38195282
A 41-Year-Old Woman with Excessive Fat of the Lower Body Since Puberty with Progression to Swollen Ankles and Feet Despite Caloric Restriction, Due to Lipedema and Protein-Calorie Malnutrition: A Case of Stage 3 Lipedema.
Wright TF, Herbst KL
Am J Case Rep 2021 May 7;22:e930306. doi: 10.12659/AJCR.930306. PMID: 33958571Free PMC Article
Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis.
Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, Lee MS, Tsai MH
Crit Care 2015 Mar 17;19(1):88. doi: 10.1186/s13054-015-0832-x. PMID: 25851781Free PMC Article
Thematic review series: patient-oriented research. What we have learned about VLDL and LDL metabolism from human kinetics studies.
Parhofer KG, Barrett PH
J Lipid Res 2006 Aug;47(8):1620-30. Epub 2006 May 23 doi: 10.1194/jlr.R600013-JLR200. PMID: 16720894
Acquired hypolipoproteinemia.
De Buyzere M, Delanghe J, Labeur C, Noens L, Benoit Y, Baert J, Rosseneu M
Clin Chem 1992 May;38(5):776-81. PMID: 1582035

Therapy

New mutations in APOB100 involved in familial hypobetalipoproteinemia.
Brusgaard K, Kjaersgaard L, Hansen AB, Husby S
J Clin Lipidol 2010 May-Jun;4(3):181-4. Epub 2010 Mar 2 doi: 10.1016/j.jacl.2010.02.009. PMID: 21122650
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation.
Wellington CL, Walker EK, Suarez A, Kwok A, Bissada N, Singaraja R, Yang YZ, Zhang LH, James E, Wilson JE, Francone O, McManus BM, Hayden MR
Lab Invest 2002 Mar;82(3):273-83. doi: 10.1038/labinvest.3780421. PMID: 11896206
Risks for hyperlipidemia.
Nestruck AC, Davignon J
Cardiol Clin 1986 Feb;4(1):47-56. PMID: 2871933
Hepatitis secondary to pyrazinamide toxicity: accompaniments of transient hypolipoproteinemia, acanthocytosis, and changes in stomach and small bowel.
Simpson AJ, Mirza AM, Martin JF, O'Brien TF Jr
South Med J 1970 Feb;63(2):138-44. PMID: 5411920

Prognosis

The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity.
Feng Q, Xia W, Dai G, Lv J, Yang J, Liu D, Zhang G
Front Immunol 2022;13:864929. Epub 2022 Jun 2 doi: 10.3389/fimmu.2022.864929. PMID: 35720307Free PMC Article
Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis.
Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, Lee MS, Tsai MH
Crit Care 2015 Mar 17;19(1):88. doi: 10.1186/s13054-015-0832-x. PMID: 25851781Free PMC Article
Significant association between hypolipoproteinemia(a) and lifetime risk of cancer: an autopsy study from a community-based Geriatric Hospital.
Mieno MN, Sawabe M, Tanaka N, Nakahara K, Hamamatsu A, Chida K, Sakurai U, Arai T, Harada K, Mori S, Inamatsu T, Ozawa T, Honma N, Aida J, Takubo K, Matsushita S
Cancer Epidemiol 2014 Oct;38(5):550-5. Epub 2014 Aug 19 doi: 10.1016/j.canep.2014.07.013. PMID: 25164551
Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients.
Venetsanou K, Vlachos K, Moles A, Fragakis G, Fildissis G, Baltopoulos G
Eur Cytokine Netw 2007 Dec;18(4):206-9. Epub 2007 Nov 12 doi: 10.1684/ecn.2007.0112. PMID: 17993453
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation.
Wellington CL, Walker EK, Suarez A, Kwok A, Bissada N, Singaraja R, Yang YZ, Zhang LH, James E, Wilson JE, Francone O, McManus BM, Hayden MR
Lab Invest 2002 Mar;82(3):273-83. doi: 10.1038/labinvest.3780421. PMID: 11896206

Clinical prediction guides

Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium.
Qu HQ, Glessner J, Qu J, Mentch F, Campbell I, Sleiman P, Connolly JJ, Hakonarson H
Metabolomics 2022 Dec 2;18(12):101. doi: 10.1007/s11306-022-01954-z. PMID: 36459297Free PMC Article
Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis.
Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, Lee MS, Tsai MH
Crit Care 2015 Mar 17;19(1):88. doi: 10.1186/s13054-015-0832-x. PMID: 25851781Free PMC Article
Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients.
Venetsanou K, Vlachos K, Moles A, Fragakis G, Fildissis G, Baltopoulos G
Eur Cytokine Netw 2007 Dec;18(4):206-9. Epub 2007 Nov 12 doi: 10.1684/ecn.2007.0112. PMID: 17993453
Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer.
Riesen W, Noseda G, Morell A, Bütler R, Barandun S, Nydegger UE
Cancer Res 1975 Mar;35(3):535-41. PMID: 163682
Wolman's disease with hypolipoproteinemia and acanthocytosis: clinical and biochemical observations.
Eto Y, Kitagawa T
J Pediatr 1970 Nov;77(5):862-7. doi: 10.1016/s0022-3476(70)80248-7. PMID: 5504079

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