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Consciousness Disorders

MedGen UID:
1099
Concept ID:
C0009792
Mental or Behavioral Dysfunction
Synonyms: Consciousness Disorder; Disorder of Consciousness; Disorders of Consciousness

Definition

Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. [from MeSH]

Professional guidelines

PubMed

Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120
Hodelín-Tablada R
MEDICC Rev 2016 Oct;18(4):43-46. doi: 10.37757/MR2016.V18.N4.9. PMID: 27829654
Lefaucheur JP, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantello RM, Cincotta M, de Carvalho M, De Ridder D, Devanne H, Di Lazzaro V, Filipović SR, Hummel FC, Jääskeläinen SK, Kimiskidis VK, Koch G, Langguth B, Nyffeler T, Oliviero A, Padberg F, Poulet E, Rossi S, Rossini PM, Rothwell JC, Schönfeldt-Lecuona C, Siebner HR, Slotema CW, Stagg CJ, Valls-Sole J, Ziemann U, Paulus W, Garcia-Larrea L
Clin Neurophysiol 2014 Nov;125(11):2150-2206. Epub 2014 Jun 5 doi: 10.1016/j.clinph.2014.05.021. PMID: 25034472

Recent clinical studies

Etiology

Alnagger N, Cardone P, Martial C, Laureys S, Annen J, Gosseries O
Presse Med 2023 Jun;52(2):104163. Epub 2023 Feb 14 doi: 10.1016/j.lpm.2022.104163. PMID: 36796250
Gaw CE, Osterhoudt KC
Pediatr Emerg Care 2019 Oct;35(10):722-730. doi: 10.1097/PEC.0000000000001946. PMID: 31593052
Pundole A, Crawford S
Neuropsychol Rehabil 2018 Dec;28(8):1285-1294. Epub 2017 Apr 6 doi: 10.1080/09602011.2017.1307766. PMID: 28385064
Eeles E, Burianova H, Pandy S, Pinsker D
Curr Aging Sci 2017;10(2):122-128. doi: 10.2174/1874609809666161004142027. PMID: 27719628
Detyniecki K, Blumenfeld H
Epilepsy Behav 2014 Jan;30:6-9. Epub 2013 Oct 12 doi: 10.1016/j.yebeh.2013.09.018. PMID: 24126026Free PMC Article

Diagnosis

Edlow BL, Gosseries O
Semin Neurol 2022 Jun;42(3):238. Epub 2022 Sep 13 doi: 10.1055/s-0042-1755400. PMID: 36100224
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Zhao J
Neurosci Bull 2018 Aug;34(4):605-614. Epub 2018 Jul 23 doi: 10.1007/s12264-018-0263-1. PMID: 30039244Free PMC Article
Horton E, Krishnamoorthy S, Reynolds L
BMJ Case Rep 2014 Jul 30;2014 doi: 10.1136/bcr-2014-205336. PMID: 25080547Free PMC Article
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Therapy

Molteni E, Canas LDS, Briand MM, Estraneo A, Font CC, Formisano R, Fufaeva E, Gosseries O, Howarth RA, Lanteri P, Licandro GI, Magee WL, Veeramuthu V, Wilson P, Yamaki T, Slomine BS; as the Special Interest Group on DoC of the International Brain Injury Association (IBIA-DoC SIG)
Neurology 2023 Aug 8;101(6):e581-e593. Epub 2023 Jun 12 doi: 10.1212/WNL.0000000000207473. PMID: 37308301Free PMC Article
Babalova L, Ruzinak R, Ballova J, Sivak S, Kantorova E, Kurca E, Zelenak K, Nosal V
Bratisl Lek Listy 2021;122(9):618-620. doi: 10.4149/BLL_2021_098. PMID: 34463105
Zhao S, Mehta AS, Zhao M
Cell Mol Life Sci 2020 Jul;77(14):2681-2699. Epub 2020 Jan 23 doi: 10.1007/s00018-019-03446-1. PMID: 31974658Free PMC Article
Thibaut A, Schiff N, Giacino J, Laureys S, Gosseries O
Lancet Neurol 2019 Jun;18(6):600-614. Epub 2019 Apr 16 doi: 10.1016/S1474-4422(19)30031-6. PMID: 31003899
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120

Prognosis

Edlow BL, Fecchio M, Bodien YG, Comanducci A, Rosanova M, Casarotto S, Young MJ, Li J, Dougherty DD, Koch C, Tononi G, Massimini M, Boly M
Neurocrit Care 2023 Jun;38(3):584-590. Epub 2023 Apr 8 doi: 10.1007/s12028-023-01706-4. PMID: 37029315Free PMC Article
Edlow BL, Claassen J, Schiff ND, Greer DM
Nat Rev Neurol 2021 Mar;17(3):135-156. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00428-x. PMID: 33318675Free PMC Article
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Zhao J
Neurosci Bull 2018 Aug;34(4):605-614. Epub 2018 Jul 23 doi: 10.1007/s12264-018-0263-1. PMID: 30039244Free PMC Article
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Clinical prediction guides

Woo JE, Azariah A, Reed EA, Gut N
Phys Med Rehabil Clin N Am 2024 Feb;35(1):127-144. Epub 2023 Jul 27 doi: 10.1016/j.pmr.2023.06.024. PMID: 37993183
Edlow BL, Fecchio M, Bodien YG, Comanducci A, Rosanova M, Casarotto S, Young MJ, Li J, Dougherty DD, Koch C, Tononi G, Massimini M, Boly M
Neurocrit Care 2023 Jun;38(3):584-590. Epub 2023 Apr 8 doi: 10.1007/s12028-023-01706-4. PMID: 37029315Free PMC Article
Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Tristán B, Gleichgerrcht E, Manes F
Handb Clin Neurol 2015;127:195-204. doi: 10.1016/B978-0-444-52892-6.00013-1. PMID: 25702218
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M
N Engl J Med 2004 Oct 28;351(18):1849-59. doi: 10.1056/NEJMoa040845. PMID: 15509818

Recent systematic reviews

Molteni E, Canas LDS, Briand MM, Estraneo A, Font CC, Formisano R, Fufaeva E, Gosseries O, Howarth RA, Lanteri P, Licandro GI, Magee WL, Veeramuthu V, Wilson P, Yamaki T, Slomine BS; as the Special Interest Group on DoC of the International Brain Injury Association (IBIA-DoC SIG)
Neurology 2023 Aug 8;101(6):e581-e593. Epub 2023 Jun 12 doi: 10.1212/WNL.0000000000207473. PMID: 37308301Free PMC Article
Ormseth CH, LaHue SC, Oldham MA, Josephson SA, Whitaker E, Douglas VC
JAMA Netw Open 2023 Jan 3;6(1):e2249950. doi: 10.1001/jamanetworkopen.2022.49950. PMID: 36607634Free PMC Article
Bai Y, Lin Y, Ziemann U
J Neurol 2021 Nov;268(11):4033-4065. Epub 2020 Sep 11 doi: 10.1007/s00415-020-10095-z. PMID: 32915309Free PMC Article
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Vanhoecke J, Hariz M
Brain Stimul 2017 Nov-Dec;10(6):1013-1023. Epub 2017 Aug 24 doi: 10.1016/j.brs.2017.08.006. PMID: 28966051

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