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Insulin coma

MedGen UID:
9496
•Concept ID:
C0021645
•
Disease or Syndrome
Synonyms: Coma, Insulin; Insulin Coma
SNOMED CT: Insulin coma (111558006)

Definition

A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInsulin coma

Professional guidelines

PubMed

'A violent thunderstorm': Cardiazol treatment in British mental hospitals.
McCrae N
Hist Psychiatry 2006 Mar;17(65 Pt 1):67-90. doi: 10.1177/0957154X06061723. PMID: 17153475
Practical management of diabetic ketoacidosis and hyperosmolar coma.
Hamblin PS, Topliss DJ, Stockigt JR
Aust N Z J Med 1990 Dec;20(6):836-41. doi: 10.1111/j.1445-5994.1990.tb00437.x. PMID: 2127177
Effectiveness of insulin coma in the treatment of schizopbrenia; a control study.
PATTERSON ES
AMA Arch Neurol Psychiatry 1958 Apr;79(4):460-7. doi: 10.1001/archneurpsyc.1958.02340040104011. PMID: 13519949

Recent clinical studies

Etiology

Improving Current Treatments for Schizophrenia.
Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376
Resolution of electroconvulsive therapy refractory major depressive disorder with unintentional hypoglycemic seizure: a case report.
Rosenblat JD, Devarajan S
J ECT 2013 Sep;29(3):e47-8. doi: 10.1097/YCT.0b013e318290fc20. PMID: 23670025
Hypoglycaemic episodes during intensified insulin treatment: increased frequency but no effect on cognitive function.
Reichard P, Berglund A, Britz A, Levander S, Rosenqvist U
J Intern Med 1991 Jan;229(1):9-16. doi: 10.1111/j.1365-2796.1991.tb00299.x. PMID: 1995769
Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
Can insulin-treated diabetics be given beta-adrenergic blocking drugs?
Barnett AH, Leslie D, Watkins PJ
Br Med J 1980 Apr 5;280(6219):976-8. doi: 10.1136/bmj.280.6219.976. PMID: 6106521Free PMC Article

Diagnosis

'A violent thunderstorm': Cardiazol treatment in British mental hospitals.
McCrae N
Hist Psychiatry 2006 Mar;17(65 Pt 1):67-90. doi: 10.1177/0957154X06061723. PMID: 17153475
Insulin-induced factitious hypoglycemic coma.
Price WA, Zimmer B, Conway R, Szekely B
Gen Hosp Psychiatry 1986 Jul;8(4):291-3. doi: 10.1016/0163-8343(86)90012-5. PMID: 3527869
Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
Hypoglycemic and hyperglycemic coma.
Hurwitz D
Surg Clin North Am 1968 Apr;48(2):361-70. doi: 10.1016/s0039-6109(16)38490-0. PMID: 4966948
ELECTROENCEPHALOGRAMS DURING COMA.
LOEB C
Acta Neurochir (Wien) 1964;12:270-81. doi: 10.1007/BF01402098. PMID: 14293381

Therapy

Improving Current Treatments for Schizophrenia.
Maric NP, Jovicic MJ, Mihaljevic M, Miljevic C
Drug Dev Res 2016 Nov;77(7):357-367. Epub 2016 Sep 16 doi: 10.1002/ddr.21337. PMID: 27633376
Does fall in tissue glucose precede fall in blood glucose?
Sternberg F, Meyerhoff C, Mennel FJ, Mayer H, Bischof F, Pfeiffer EF
Diabetologia 1996 May;39(5):609-12. doi: 10.1007/BF00403309. PMID: 8739922
Dead in bed syndrome: a new manifestation of nocturnal hypoglycaemia?
Campbell I
Diabet Med 1991 Jan;8(1):3-4. doi: 10.1111/j.1464-5491.1991.tb01507.x. PMID: 1826241
Insulin-induced factitious hypoglycemic coma.
Price WA, Zimmer B, Conway R, Szekely B
Gen Hosp Psychiatry 1986 Jul;8(4):291-3. doi: 10.1016/0163-8343(86)90012-5. PMID: 3527869
Hypoglycaemia.
Gale E
Clin Endocrinol Metab 1980 Nov;9(3):461-75. PMID: 6260399

Prognosis

Rudolf Karl Freudenberg - from pioneer of insulin treatment to pioneering social psychiatrist.
Becker T, Bennett D
Hist Psychiatry 2000 Jun;11(42 Pt 2):189-211. doi: 10.1177/0957154X0001104204. PMID: 11624662
Long-term follow-up of patients with a diagnosis of paranoid state and hospitalized, 1913 to 1940.
Stephens JH, Richard P, McHugh PR
J Nerv Ment Dis 2000 Apr;188(4):202-8. doi: 10.1097/00005053-200004000-00002. PMID: 10789996
Hypoglycaemia unawareness in diabetics transferred from beef/porcine insulin to human insulin.
Teuscher A, Berger WG
Lancet 1987 Aug 15;2(8555):382-5. doi: 10.1016/s0140-6736(87)92394-4. PMID: 2886833
Factitious brittle diabetes mellitus.
Schade DS, Drumm DA, Eaton RP, Sterling WA
Am J Med 1985 May;78(5):777-84. doi: 10.1016/0002-9343(85)90283-9. PMID: 3922220
ELECTRIC AND INSULIN SHOCK THERAPY DURING PREGNANCY.
IMPASTATO DJ, GABRIEL AR, LARDARO HH
Dis Nerv Syst 1964 Sep;25:542-6. PMID: 14215244

Clinical prediction guides

Hypoglycemic neuropathy.
Mohseni S
Acta Neuropathol 2001 Nov;102(5):413-21. doi: 10.1007/s004010100459. PMID: 11699552
Long-term follow-up of patients with a diagnosis of paranoid state and hospitalized, 1913 to 1940.
Stephens JH, Richard P, McHugh PR
J Nerv Ment Dis 2000 Apr;188(4):202-8. doi: 10.1097/00005053-200004000-00002. PMID: 10789996
Reversible decerebrate posturing after profound and prolonged hypoglycemia.
Kirk MM, Hoogwerf BJ, Stoller JK
Cleve Clin J Med 1991 Jul-Aug;58(4):361-3. doi: 10.3949/ccjm.58.4.361. PMID: 1889117
Diabetes mellitus and Graves' disease in pregnancy complicated by maternal allergies to antithyroid medication.
Bruner JP, Landon MB, Gabbe SG
Obstet Gynecol 1988 Sep;72(3 Pt 2):443-5. PMID: 3405562
The effect of insulin-induced hypoglycemia with and without atropine on plasma vasoactive intestinal polypeptide in man.
Lygren I, Burhol PG, Jorde R, Waldum HL
Scand J Gastroenterol 1983 Jan;18(1):155-9. doi: 10.3109/00365528309181576. PMID: 6675173

Recent systematic reviews

Electroconvulsive therapy for schizophrenia.
Tharyan P
Cochrane Database Syst Rev 2000;(2):CD000076. doi: 10.1002/14651858.CD000076. PMID: 10796292

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