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Intermediate coronary syndrome

MedGen UID:
296
•Concept ID:
C0002965
•
Disease or Syndrome
Synonyms: Angina at Rest; Angina Pectori, Unstable; Angina Pectoris, Unstable; Angina, Preinfarction; Angina, Unstable; Anginas, Preinfarction; Anginas, Unstable; Preinfarction Angina; Preinfarction Anginas; Unstable Angina; Unstable Angina Pectori; Unstable Angina Pectoris; Unstable Anginas
SNOMED CT: Impending infarction (25106000); Worsening angina (4557003); Unstable angina (4557003); Intermediate coronary syndrome (4557003); Crescendo angina (4557003)
 
Monarch Initiative: MONDO:0006805

Definition

Angina pectoris (or equivalent type of ischemic discomfort) which has recently changed in frequency, duration, intensity, or occurs at rest. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntermediate coronary syndrome

Professional guidelines

PubMed

Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies.
Xenogiannis I, Zenati M, Bhatt DL, Rao SV, Rodés-Cabau J, Goldman S, Shunk KA, Mavromatis K, Banerjee S, Alaswad K, Nikolakopoulos I, Vemmou E, Karacsonyi J, Alexopoulos D, Burke MN, Bapat VN, Brilakis ES
Circulation 2021 Aug 31;144(9):728-745. Epub 2021 Aug 30 doi: 10.1161/CIRCULATIONAHA.120.052163. PMID: 34460327
Prevalence, treatment, and control of chest pain syndromes and associated risk factors in hypertensive patients.
Hendrix KH, Mayhan S, Lackland DT, Egan BM
Am J Hypertens 2005 Aug;18(8):1026-32. doi: 10.1016/j.amjhyper.2005.02.016. PMID: 16109315
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention.
Robertson GC
Am J Cardiol 2000 Mar 9;85(5A):21B-26B. doi: 10.1016/s0002-9149(00)00808-0. PMID: 11076127

Recent clinical studies

Etiology

Prevalence, treatment, and control of chest pain syndromes and associated risk factors in hypertensive patients.
Hendrix KH, Mayhan S, Lackland DT, Egan BM
Am J Hypertens 2005 Aug;18(8):1026-32. doi: 10.1016/j.amjhyper.2005.02.016. PMID: 16109315
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention.
Robertson GC
Am J Cardiol 2000 Mar 9;85(5A):21B-26B. doi: 10.1016/s0002-9149(00)00808-0. PMID: 11076127
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome.
Grande P, Grauholt AM, Madsen JK
Circulation 1990 Jan;81(1 Suppl):I16-9; discussion I22-3. PMID: 2136815
Pathophysiologic significance of S-T and T wave abnormalities in patients with the intermediate coronary syndrome.
Bodenheimer MM, Banka VS, Trout RG, Hermann GA, Pasdar H, Helfant RH
Am J Cardiol 1977 Feb;39(2):153-8. doi: 10.1016/s0002-9149(77)80184-7. PMID: 299974
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects.
Fischl SJ, Herman MV, Gorlin R
N Engl J Med 1973 Jun 7;288(23):1193-8. doi: 10.1056/NEJM197306072882301. PMID: 4144755

Diagnosis

Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study).
Stoupel E, Radishauskas R, Bernotiene G, Tamoshiunas A, Virvichiute D
J Basic Clin Physiol Pharmacol 2018 Jun 27;29(3):257-263. doi: 10.1515/jbcpp-2017-0148. PMID: 29397386
The intermediate coronary syndrome.
Scanlon PJ
Prog Cardiovasc Dis 1981 Mar-Apr;23(5):351-64. doi: 10.1016/0033-0620(81)90021-9. PMID: 6971456
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects.
Fischl SJ, Herman MV, Gorlin R
N Engl J Med 1973 Jun 7;288(23):1193-8. doi: 10.1056/NEJM197306072882301. PMID: 4144755
THE INTERMEDIATE CORONARY SYNDROME.
COSBY RS
Dis Chest 1963 Sep;44:251-7. doi: 10.1378/chest.44.3.251. PMID: 14061336
Intermediate coronary syndrome.
VAKIL RJ
Circulation 1961 Sep;24:557-71. doi: 10.1161/01.cir.24.3.557. PMID: 13779654

Therapy

Use of secondary prevention drug therapy in patients with acute coronary syndrome after hospital discharge.
Lee HY, Cooke CE, Robertson TA
J Manag Care Pharm 2008 Apr;14(3):271-80. doi: 10.18553/jmcp.2008.14.3.271. PMID: 18439049Free PMC Article
Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention.
Robertson GC
Am J Cardiol 2000 Mar 9;85(5A):21B-26B. doi: 10.1016/s0002-9149(00)00808-0. PMID: 11076127
The intermediate coronary syndrome.
Scanlon PJ
Prog Cardiovasc Dis 1981 Mar-Apr;23(5):351-64. doi: 10.1016/0033-0620(81)90021-9. PMID: 6971456
Editorial: Intermediate coronary syndrome.
Br Med J 1973 Sep 22;3(5881):601-2. doi: 10.1136/bmj.3.5881.601. PMID: 4148257Free PMC Article
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects.
Fischl SJ, Herman MV, Gorlin R
N Engl J Med 1973 Jun 7;288(23):1193-8. doi: 10.1056/NEJM197306072882301. PMID: 4144755

Prognosis

Management of intermediate coronary syndrome: role of conservative treatment, glycoprotein IIb/IIIa receptor inhibitors, and direct intervention.
Robertson GC
Am J Cardiol 2000 Mar 9;85(5A):21B-26B. doi: 10.1016/s0002-9149(00)00808-0. PMID: 11076127
Unstable angina pectoris. Platelet behavior and prognosis in progressive angina and intermediate coronary syndrome.
Grande P, Grauholt AM, Madsen JK
Circulation 1990 Jan;81(1 Suppl):I16-9; discussion I22-3. PMID: 2136815
The intermediate coronary syndrome.
Scanlon PJ
Prog Cardiovasc Dis 1981 Mar-Apr;23(5):351-64. doi: 10.1016/0033-0620(81)90021-9. PMID: 6971456
Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome.
Telford AM, Wilson C
Lancet 1981 Jun 6;1(8232):1225-8. doi: 10.1016/s0140-6736(81)92399-0. PMID: 6112564
The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects.
Fischl SJ, Herman MV, Gorlin R
N Engl J Med 1973 Jun 7;288(23):1193-8. doi: 10.1056/NEJM197306072882301. PMID: 4144755

Clinical prediction guides

Effect of the clopidogrel-proton pump inhibitor drug interaction on adverse cardiovascular events in patients with acute coronary syndrome.
Bhurke SM, Martin BC, Li C, Franks AM, Bursac Z, Said Q
Pharmacotherapy 2012 Sep;32(9):809-18. Epub 2012 Jun 28 doi: 10.1002/j.1875-9114.2012.01112.x. PMID: 22744772Free PMC Article
Use of secondary prevention drug therapy in patients with acute coronary syndrome after hospital discharge.
Lee HY, Cooke CE, Robertson TA
J Manag Care Pharm 2008 Apr;14(3):271-80. doi: 10.18553/jmcp.2008.14.3.271. PMID: 18439049Free PMC Article
Intracoronary thrombus in syndromes of unstable myocardial ischemia.
Vetrovec GW, Cowley MJ, Overton H, Richardson DW
Am Heart J 1981 Dec;102(6 Pt 2):1202-8. doi: 10.1016/0002-8703(81)90653-0. PMID: 7315724
Precordial ST-segment mapping. 4. Experience with mapping of ST-segment depression in anterior transmural myocardial infarction.
Madias JE, Hood WB Jr
J Electrocardiol 1976;9(4):315-20. doi: 10.1016/s0022-0736(76)80023-4. PMID: 978082
Prinzmetal's angina Clinical and anatomic aspects.
Allaire BI, Schroeder JS
West J Med 1975 Mar;122(3):187-93. PMID: 1146290Free PMC Article

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