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Anaplasmosis

MedGen UID:
8053
•Concept ID:
C0002797
•
Disease or Syndrome
Synonyms: Anaplasma Infection; Anaplasma Infections; Anaplasma phagocytophilum Infection; Anaplasma phagocytophilum Infections; Anaplasmoses; Infection, Anaplasma; Infections, Anaplasma
SNOMED CT: Anaplasmosis (13906002); Gallsickness (13906002)
 
Monarch Initiative: MONDO:0025303

Definition

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplasmosis

Professional guidelines

PubMed

Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome.
Kim DM, Yu BJ, Kim DY, Seo JW, Yun NR, Kim CM, Kim YK, Jung SI, Kim UJ, Kim SE, Kim HA, Kim ES, Hur J, Lee SH, Jeong HW, Heo JY, Jung DS, Kim J, Park SH, Kwak YG, Lee S, Lim S, Chatterjee S
Sci Rep 2023 Apr 26;13(1):6837. doi: 10.1038/s41598-023-32061-1. PMID: 37100782Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article

Recent clinical studies

Etiology

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.
Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Human granulocytic anaplasmosis.
Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228Free PMC Article
Prevention of tick-borne diseases.
Piesman J, Eisen L
Annu Rev Entomol 2008;53:323-43. doi: 10.1146/annurev.ento.53.103106.093429. PMID: 17877457

Diagnosis

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Tick-Borne Illnesses.
Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018
Human granulocytic anaplasmosis.
Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228Free PMC Article

Therapy

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tick borne illness-Lyme disease.
Bush LM, Vazquez-Pertejo MT
Dis Mon 2018 May;64(5):195-212. doi: 10.1016/j.disamonth.2018.01.007. PMID: 29402399
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Human granulocytic anaplasmosis.
Bakken JS, Dumler S
Infect Dis Clin North Am 2008 Sep;22(3):433-48, viii. doi: 10.1016/j.idc.2008.03.011. PMID: 18755383

Prognosis

Zoonotic Babesia: A scoping review of the global evidence.
Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Babesiosis Surveillance - Wisconsin, 2001-2015.
Stein E, Elbadawi LI, Kazmierczak J, Davis JP
MMWR Morb Mortal Wkly Rep 2017 Jul 7;66(26):687-691. doi: 10.15585/mmwr.mm6626a2. PMID: 28683059Free PMC Article
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Lyme Disease Coinfections in the United States.
Caulfield AJ, Pritt BS
Clin Lab Med 2015 Dec;35(4):827-46. Epub 2015 Sep 1 doi: 10.1016/j.cll.2015.07.006. PMID: 26593260

Clinical prediction guides

Detection of Anaplasma and Ehrlichia bacteria in humans, wildlife, and ticks in the Amazon rainforest.
Buysse M, Koual R, Binetruy F, de Thoisy B, Baudrimont X, Garnier S, Douine M, Chevillon C, Delsuc F, Catzeflis F, Bouchon D, Duron O
Nat Commun 2024 May 11;15(1):3988. doi: 10.1038/s41467-024-48459-y. PMID: 38734682Free PMC Article
Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community.
Self SCW, Liu Y, Nordone SK, Yabsley MJ, Walden HS, Lund RB, Bowman DD, Carpenter C, McMahan CS, Gettings JR
Anim Health Res Rev 2019 Jun;20(1):47-60. Epub 2019 Sep 26 doi: 10.1017/S1466252319000045. PMID: 31895020
Zoonotic Babesia: A scoping review of the global evidence.
Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Distribution of tick-borne diseases in China.
Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ
Parasit Vectors 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899Free PMC Article

Recent systematic reviews

Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.
Schudel S, Gygax L, Kositz C, Kuenzli E, Neumayr A
PLoS Negl Trop Dis 2024 Aug;18(8):e0012313. Epub 2024 Aug 5 doi: 10.1371/journal.pntd.0012313. PMID: 39102427Free PMC Article
Epidemiological and phylogenetic characteristics of emerging Anaplasma capra: A systematic review with modeling analysis.
Lin ZT, Ye RZ, Liu JY, Wang XY, Zhu WJ, Li YY, Cui XM, Cao WC
Infect Genet Evol 2023 Nov;115:105510. Epub 2023 Sep 30 doi: 10.1016/j.meegid.2023.105510. PMID: 37778674
Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.
Fischhoff IR, Bowden SE, Keesing F, Ostfeld RS
BMC Infect Dis 2019 Oct 17;19(1):861. doi: 10.1186/s12879-019-4484-3. PMID: 31623574Free PMC Article
Repellence of essential oils and selected compounds against ticks-A systematic review.
Benelli G, Pavela R
Acta Trop 2018 Mar;179:47-54. Epub 2017 Dec 26 doi: 10.1016/j.actatropica.2017.12.025. PMID: 29287758
Epidemiology and control of human granulocytic anaplasmosis: a systematic review.
Jin H, Wei F, Liu Q, Qian J
Vector Borne Zoonotic Dis 2012 Apr;12(4):269-74. Epub 2012 Jan 4 doi: 10.1089/vbz.2011.0753. PMID: 22217177

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