U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
  • The following terms were not found in MedGen: Benzenethiol, tribromide, 6-tribromide.

Grade 1 Hearing Impaired, CTCAE

MedGen UID:
1634890
•Concept ID:
C4685182
•
Finding

Definition

Adults enrolled on a Monitoring Program (on a 1, 2, 4, 3, 6, and 8 kHz audiogram): Threshold shift of 15-25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Subjective change in hearing in the absence of documented hearing loss; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB hearing loss (HL) (i.e., 25 dB HL or greater); sensorineural hearing loss (SNHL) above 4 kHz (i.e., 6 or 8 kHz) in at least one ear [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Hearing Impaired, CTCAE

Professional guidelines

PubMed

Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor.
Polski B, Sosnowska-Sienkiewicz P, Szydłowski J, Januszkiewicz-Lewandowska D
Audiol Neurootol 2023;28(1):32-42. Epub 2022 Oct 3 doi: 10.1159/000526403. PMID: 36191558
Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.
Chan SL, Ng LS, Goh X, Siow CH, Goh HL, Goh BC, Cheo T, Loh KS, Brunham LR
Head Neck 2018 Jul;40(7):1425-1433. Epub 2018 Feb 16 doi: 10.1002/hed.25112. PMID: 29451951

Recent clinical studies

Etiology

Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor.
Polski B, Sosnowska-Sienkiewicz P, Szydłowski J, Januszkiewicz-Lewandowska D
Audiol Neurootol 2023;28(1):32-42. Epub 2022 Oct 3 doi: 10.1159/000526403. PMID: 36191558
Feasibility of Proton Beam Therapy for Infants with Brain Tumours: Experiences from the Prospective KiProReg Registry Study.
Jazmati D, Steinmeier T, Ahamd Khalil D, Frisch S, Peters S, Schulze Schleithoff S, Bäumer C, Rutkowski S, Frühwald MC, Blase C, Tippelt S, Timmermann B
Clin Oncol (R Coll Radiol) 2021 Jul;33(7):e295-e304. Epub 2021 Apr 3 doi: 10.1016/j.clon.2021.03.006. PMID: 33820696
Atorvastatin is associated with reduced cisplatin-induced hearing loss.
Fernandez KA, Allen P, Campbell M, Page B, Townes T, Li CM, Cheng H, Garrett J, Mulquin M, Clements A, Mulford D, Ortiz C, Brewer C, Dubno JR, Newlands S, Schmitt NC, Cunningham LL
J Clin Invest 2021 Jan 4;131(1) doi: 10.1172/JCI142616. PMID: 33393488Free PMC Article
Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.
Simon F, Feuvret L, Bresson D, Guichard JP, El Zein S, Bernat AL, Labidi M, Calugaru V, Froelich S, Herman P, Verillaud B
PLoS One 2018;13(12):e0208786. Epub 2018 Dec 17 doi: 10.1371/journal.pone.0208786. PMID: 30557382Free PMC Article
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, Walker D, Makin G, Bandi S, Pizer B, Hawcutt DB, Pirmohamed M
Pharmacogenet Genomics 2017 Jun;27(6):213-222. doi: 10.1097/FPC.0000000000000281. PMID: 28445188Free PMC Article

Diagnosis

Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor.
Polski B, Sosnowska-Sienkiewicz P, Szydłowski J, Januszkiewicz-Lewandowska D
Audiol Neurootol 2023;28(1):32-42. Epub 2022 Oct 3 doi: 10.1159/000526403. PMID: 36191558
Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.
Simon F, Feuvret L, Bresson D, Guichard JP, El Zein S, Bernat AL, Labidi M, Calugaru V, Froelich S, Herman P, Verillaud B
PLoS One 2018;13(12):e0208786. Epub 2018 Dec 17 doi: 10.1371/journal.pone.0208786. PMID: 30557382Free PMC Article
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, Walker D, Makin G, Bandi S, Pizer B, Hawcutt DB, Pirmohamed M
Pharmacogenet Genomics 2017 Jun;27(6):213-222. doi: 10.1097/FPC.0000000000000281. PMID: 28445188Free PMC Article
Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group.
Knight KR, Chen L, Freyer D, Aplenc R, Bancroft M, Bliss B, Dang H, Gillmeister B, Hendershot E, Kraemer DF, Lindenfeld L, Meza J, Neuwelt EA, Pollock BH, Sung L
J Clin Oncol 2017 Feb;35(4):440-445. Epub 2016 Dec 12 doi: 10.1200/JCO.2016.69.2319. PMID: 27937095Free PMC Article
Evolution of neurological impairment in pediatric infratentorial ependymoma patients.
Morris EB, Li C, Khan RB, Sanford RA, Boop F, Pinlac R, Xiong X, Merchant TE
J Neurooncol 2009 Sep;94(3):391-8. Epub 2009 Mar 29 doi: 10.1007/s11060-009-9866-8. PMID: 19330288Free PMC Article

Therapy

Atorvastatin is associated with reduced cisplatin-induced hearing loss.
Fernandez KA, Allen P, Campbell M, Page B, Townes T, Li CM, Cheng H, Garrett J, Mulquin M, Clements A, Mulford D, Ortiz C, Brewer C, Dubno JR, Newlands S, Schmitt NC, Cunningham LL
J Clin Invest 2021 Jan 4;131(1) doi: 10.1172/JCI142616. PMID: 33393488Free PMC Article
Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.
Simon F, Feuvret L, Bresson D, Guichard JP, El Zein S, Bernat AL, Labidi M, Calugaru V, Froelich S, Herman P, Verillaud B
PLoS One 2018;13(12):e0208786. Epub 2018 Dec 17 doi: 10.1371/journal.pone.0208786. PMID: 30557382Free PMC Article
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, Walker D, Makin G, Bandi S, Pizer B, Hawcutt DB, Pirmohamed M
Pharmacogenet Genomics 2017 Jun;27(6):213-222. doi: 10.1097/FPC.0000000000000281. PMID: 28445188Free PMC Article
Late Toxicities of Intensity-Modulated Radiation Therapy for Head and Neck Rhabdomyosarcoma.
Lockney NA, Friedman DN, Wexler LH, Sklar CA, Casey DL, Wolden SL
Pediatr Blood Cancer 2016 Sep;63(9):1608-14. Epub 2016 May 16 doi: 10.1002/pbc.26061. PMID: 27195454Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article

Prognosis

Atorvastatin is associated with reduced cisplatin-induced hearing loss.
Fernandez KA, Allen P, Campbell M, Page B, Townes T, Li CM, Cheng H, Garrett J, Mulquin M, Clements A, Mulford D, Ortiz C, Brewer C, Dubno JR, Newlands S, Schmitt NC, Cunningham LL
J Clin Invest 2021 Jan 4;131(1) doi: 10.1172/JCI142616. PMID: 33393488Free PMC Article
Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.
Simon F, Feuvret L, Bresson D, Guichard JP, El Zein S, Bernat AL, Labidi M, Calugaru V, Froelich S, Herman P, Verillaud B
PLoS One 2018;13(12):e0208786. Epub 2018 Dec 17 doi: 10.1371/journal.pone.0208786. PMID: 30557382Free PMC Article
Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population.
Chan SL, Ng LS, Goh X, Siow CH, Goh HL, Goh BC, Cheo T, Loh KS, Brunham LR
Head Neck 2018 Jul;40(7):1425-1433. Epub 2018 Feb 16 doi: 10.1002/hed.25112. PMID: 29451951
Evolution of neurological impairment in pediatric infratentorial ependymoma patients.
Morris EB, Li C, Khan RB, Sanford RA, Boop F, Pinlac R, Xiong X, Merchant TE
J Neurooncol 2009 Sep;94(3):391-8. Epub 2009 Mar 29 doi: 10.1007/s11060-009-9866-8. PMID: 19330288Free PMC Article
Carbon ion radiotherapy of skull base chondrosarcomas.
Schulz-Ertner D, Nikoghosyan A, Hof H, Didinger B, Combs SE, Jäkel O, Karger CP, Edler L, Debus J
Int J Radiat Oncol Biol Phys 2007 Jan 1;67(1):171-7. Epub 2006 Oct 23 doi: 10.1016/j.ijrobp.2006.08.027. PMID: 17056193

Clinical prediction guides

Combined Photon and Carbon Ion Radiation Therapy for Sinonasal Malignancies: Results of the HIT-SNT Prospective Phase 2 Trial.
Weusthof K, Held T, Lang K, Rachel ZE, Harrabi SB, Plath K, Freudlsperger C, Herfarth K, Debus J, Haberer T, Münter M, Jensen AD, Adeberg S
Int J Radiat Oncol Biol Phys 2024 Apr 1;118(5):1563-1574. Epub 2023 Oct 20 doi: 10.1016/j.ijrobp.2023.09.037. PMID: 37866761
Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor.
Polski B, Sosnowska-Sienkiewicz P, Szydłowski J, Januszkiewicz-Lewandowska D
Audiol Neurootol 2023;28(1):32-42. Epub 2022 Oct 3 doi: 10.1159/000526403. PMID: 36191558
Surgery and protontherapy in Grade I and II skull base chondrosarcoma: A comparative retrospective study.
Simon F, Feuvret L, Bresson D, Guichard JP, El Zein S, Bernat AL, Labidi M, Calugaru V, Froelich S, Herman P, Verillaud B
PLoS One 2018;13(12):e0208786. Epub 2018 Dec 17 doi: 10.1371/journal.pone.0208786. PMID: 30557382Free PMC Article
Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck.
Andrä C, Rauch J, Li M, Ganswindt U, Belka C, Saleh-Ebrahimi L, Ballhausen H, Nachbichler SB, Roeder F
Radiat Oncol 2015 Jul 10;10:140. doi: 10.1186/s13014-015-0449-x. PMID: 26156022Free PMC Article
Carbon ion radiotherapy of skull base chondrosarcomas.
Schulz-Ertner D, Nikoghosyan A, Hof H, Didinger B, Combs SE, Jäkel O, Karger CP, Edler L, Debus J
Int J Radiat Oncol Biol Phys 2007 Jan 1;67(1):171-7. Epub 2006 Oct 23 doi: 10.1016/j.ijrobp.2006.08.027. PMID: 17056193

Recent systematic reviews

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, Walker D, Makin G, Bandi S, Pizer B, Hawcutt DB, Pirmohamed M
Pharmacogenet Genomics 2017 Jun;27(6):213-222. doi: 10.1097/FPC.0000000000000281. PMID: 28445188Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...