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Myocardial disorder

MedGen UID:
469033
•Concept ID:
C3241958
•
Disease or Syndrome
Synonyms: disease of myocardium; disease or disorder of myocardium; disorder of heart muscle; disorder of myocardium; myocardial disease; Myocardial Disorder; myocardial disorder; myocardium disease; myocardium disease or disorder
 
Monarch Initiative: MONDO:0024643

Definition

A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial disorder

Professional guidelines

PubMed

Guidelines for the diagnosis and management of familial dilated cardiomyopathy.
Fatkin D; members of the CSANZ Cardiac Genetic Diseases Council Writing Group
Heart Lung Circ 2011 Nov;20(11):691-3. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.008. PMID: 21885340
Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy.
Smith W; Members of CSANZ Cardiovascular Genetics Working Group
Heart Lung Circ 2011 Dec;20(12):757-60. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.019. PMID: 21885338
Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.
Wang L, Seidman JG, Seidman CE
Ann Intern Med 2010 Apr 20;152(8):513-20, W181. doi: 10.7326/0003-4819-152-8-201004200-00008. PMID: 20404382Free PMC Article

Recent clinical studies

Etiology

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.
Yacoub MS, El-Nakhal T, Hasabo EA, Shehata N, Wilson K, Ismail KH, Bakr MS, Mohsen M, Mohamed A, Abdelazim E, Ali HT, Soliman Z, Sayed A, Abdelsayed K, Caliskan K, Soliman O
Heart Fail Rev 2024 Mar;29(2):479-496. Epub 2023 Dec 19 doi: 10.1007/s10741-023-10375-6. PMID: 38112937
An Overview of Diabetic Cardiomyopathy.
Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.
Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R
Sci Adv 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. PMID: 37506209
Hypertrophic Cardiomyopathy: New Concepts and Therapies.
Maron BJ, Rowin EJ, Maron MS
Annu Rev Med 2022 Jan 27;73:363-375. doi: 10.1146/annurev-med-042220-021539. PMID: 35084989
Genetics of restrictive cardiomyopathy.
Sen-Chowdhry S, Syrris P, McKenna WJ
Heart Fail Clin 2010 Apr;6(2):179-86. doi: 10.1016/j.hfc.2009.11.005. PMID: 20347786

Diagnosis

An Overview of Diabetic Cardiomyopathy.
Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898
A review of fibroblast growth factor 21 in diabetic cardiomyopathy.
Zhang X, Yang L, Xu X, Tang F, Yi P, Qiu B, Hao Y
Heart Fail Rev 2019 Nov;24(6):1005-1017. doi: 10.1007/s10741-019-09809-x. PMID: 31175491
Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy.
Viola HM, Hool LC
Arch Biochem Biophys 2019 Apr 15;665:166-174. Epub 2019 Mar 16 doi: 10.1016/j.abb.2019.03.006. PMID: 30885674
Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.
Asimaki A, Saffitz JE
Cell Commun Adhes 2014 Feb;21(1):13-23. doi: 10.3109/15419061.2013.876016. PMID: 24460198Free PMC Article
Left ventricular noncompaction.
Pantazis AA, Elliott PM
Curr Opin Cardiol 2009 May;24(3):209-13. doi: 10.1097/HCO.0b013e32832a11e7. PMID: 19318934

Therapy

Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten.
Amesz JH, Langmuur SJJ, Zhang L, Manintveld OC, Schinkel AFL, de Jong PL, de Groot NMS, Taverne YJHJ
Biomed Pharmacother 2024 Jan;170:116036. Epub 2023 Dec 21 doi: 10.1016/j.biopha.2023.116036. PMID: 38134635
A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.
Yacoub MS, El-Nakhal T, Hasabo EA, Shehata N, Wilson K, Ismail KH, Bakr MS, Mohsen M, Mohamed A, Abdelazim E, Ali HT, Soliman Z, Sayed A, Abdelsayed K, Caliskan K, Soliman O
Heart Fail Rev 2024 Mar;29(2):479-496. Epub 2023 Dec 19 doi: 10.1007/s10741-023-10375-6. PMID: 38112937
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.
Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R
Sci Adv 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. PMID: 37506209
Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy.
Smith W; Members of CSANZ Cardiovascular Genetics Working Group
Heart Lung Circ 2011 Dec;20(12):757-60. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.019. PMID: 21885338
New treatment strategies for hypertrophic obstructive cardiomyopathy: alcohol ablation of the septum: the new gold standard?
Hess OM, Sigwart U
J Am Coll Cardiol 2004 Nov 16;44(10):2054-5. doi: 10.1016/j.jacc.2004.08.047. PMID: 15542291

Prognosis

An Overview of Diabetic Cardiomyopathy.
Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898
Prognosis and subtype analysis of left ventricular noncompaction in adults: A retrospective multicenter study.
Feng Y, Ning L, Zhang J, Wang H, Zhang H, Zhang R, Deng Z, Ni Y, Ye Y, Ma A, Zhang Y, Wang T
Clin Cardiol 2023 Apr;46(4):390-396. Epub 2023 Feb 13 doi: 10.1002/clc.23991. PMID: 36779545Free PMC Article
When rare illuminates common: how cardiocutaneous syndromes transformed our perspective on arrhythmogenic cardiomyopathy.
Sen-Chowdhry S, McKenna WJ
Cell Commun Adhes 2014 Feb;21(1):3-11. doi: 10.3109/15419061.2013.876415. PMID: 24460197
Isolated left ventricular noncompaction: what do we really know?
Peters F, Khandheria BK
Curr Cardiol Rep 2012 Jun;14(3):381-8. doi: 10.1007/s11886-012-0255-0. PMID: 22415394
Risk stratification in hypertrophic cardiomyopathy.
Vassalli G, Seiler C, Hess OM
Curr Opin Cardiol 1994 May;9(3):330-6. doi: 10.1097/00001573-199405000-00011. PMID: 8049590

Clinical prediction guides

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.
Yacoub MS, El-Nakhal T, Hasabo EA, Shehata N, Wilson K, Ismail KH, Bakr MS, Mohsen M, Mohamed A, Abdelazim E, Ali HT, Soliman Z, Sayed A, Abdelsayed K, Caliskan K, Soliman O
Heart Fail Rev 2024 Mar;29(2):479-496. Epub 2023 Dec 19 doi: 10.1007/s10741-023-10375-6. PMID: 38112937
An Overview of Diabetic Cardiomyopathy.
Quaiyoom A, Kumar R
Curr Diabetes Rev 2024;20(5):e121023222139. doi: 10.2174/0115733998255538231001122639. PMID: 37842898
Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy.
Viola HM, Hool LC
Arch Biochem Biophys 2019 Apr 15;665:166-174. Epub 2019 Mar 16 doi: 10.1016/j.abb.2019.03.006. PMID: 30885674
Nomenclature and systems of classification for cardiomyopathy in children.
Konta L, Franklin RC, Kaski JP
Cardiol Young 2015 Aug;25 Suppl 2:31-42. doi: 10.1017/S1047951115001201. PMID: 26377708
Genetics of restrictive cardiomyopathy.
Sen-Chowdhry S, Syrris P, McKenna WJ
Heart Fail Clin 2010 Apr;6(2):179-86. doi: 10.1016/j.hfc.2009.11.005. PMID: 20347786

Recent systematic reviews

A systematic review and meta-analysis of the efficacy and safety of Mavacamten therapy in international cohort of 524 patients with hypertrophic cardiomyopathy.
Yacoub MS, El-Nakhal T, Hasabo EA, Shehata N, Wilson K, Ismail KH, Bakr MS, Mohsen M, Mohamed A, Abdelazim E, Ali HT, Soliman Z, Sayed A, Abdelsayed K, Caliskan K, Soliman O
Heart Fail Rev 2024 Mar;29(2):479-496. Epub 2023 Dec 19 doi: 10.1007/s10741-023-10375-6. PMID: 38112937

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