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Spotted fever

MedGen UID:
1826170
•Concept ID:
C5680374
•
Disease or Syndrome
Synonym: Spotted fever rickettsiosis
 
Monarch Initiative: MONDO:0001195
Orphanet: ORPHA102022

Definition

A type of tick-borne disease which presents on the skin caused by bacteria of the genus Rickettsia. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpotted fever

Professional guidelines

PubMed

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature.
Gottlieb M, Long B, Koyfman A
J Emerg Med 2018 Jul;55(1):42-50. Epub 2018 Apr 22 doi: 10.1016/j.jemermed.2018.02.043. PMID: 29685474
Recognition of and Prompt Treatment for Tick-Borne Infections in Children.
Mukkada S, Buckingham SC
Infect Dis Clin North Am 2015 Sep;29(3):539-55. Epub 2015 Jul 16 doi: 10.1016/j.idc.2015.05.002. PMID: 26188606

Recent clinical studies

Etiology

Rickettsia-Host-Tick Interactions: Knowledge Advances and Gaps.
Kim HK
Infect Immun 2022 Sep 15;90(9):e0062121. Epub 2022 Aug 22 doi: 10.1128/iai.00621-21. PMID: 35993770Free PMC Article
Japanese Spotted Fever.
Ishizuka K, Sugaya M
N Engl J Med 2022 Aug 4;387(5):451. doi: 10.1056/NEJMicm2119475. PMID: 35921453
The Rickettsioses: A Practical Update.
Blanton LS
Infect Dis Clin North Am 2019 Mar;33(1):213-229. doi: 10.1016/j.idc.2018.10.010. PMID: 30712763Free PMC Article
Rocky Mountain Spotted Fever.
Phillips J
Workplace Health Saf 2017 Jan;65(1):48. doi: 10.1177/2165079916683711. PMID: 28055518
No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever.
Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ
J Pediatr 2015 May;166(5):1246-51. Epub 2015 Mar 17 doi: 10.1016/j.jpeds.2015.02.015. PMID: 25794784

Diagnosis

Fever and Rash.
Gonzales Y Tucker RD, Addepalli A
Emerg Med Clin North Am 2024 May;42(2):303-334. Epub 2024 Mar 7 doi: 10.1016/j.emc.2024.01.005. PMID: 38641393
Japanese Spotted Fever.
Ishizuka K, Sugaya M
N Engl J Med 2022 Aug 4;387(5):451. doi: 10.1056/NEJMicm2119475. PMID: 35921453
The Rickettsioses: A Practical Update.
Blanton LS
Infect Dis Clin North Am 2019 Mar;33(1):213-229. doi: 10.1016/j.idc.2018.10.010. PMID: 30712763Free PMC Article
Tick-Borne Illnesses.
Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018
Dermatologic emergencies.
Usatine RP, Sandy N
Am Fam Physician 2010 Oct 1;82(7):773-80. PMID: 20879700

Therapy

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
The Rickettsioses: A Practical Update.
Blanton LS
Infect Dis Clin North Am 2019 Mar;33(1):213-229. doi: 10.1016/j.idc.2018.10.010. PMID: 30712763Free PMC Article
No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever.
Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ
J Pediatr 2015 May;166(5):1246-51. Epub 2015 Mar 17 doi: 10.1016/j.jpeds.2015.02.015. PMID: 25794784
Dermatologic emergencies.
Usatine RP, Sandy N
Am Fam Physician 2010 Oct 1;82(7):773-80. PMID: 20879700
The tetracyclines.
Smilack JD
Mayo Clin Proc 1999 Jul;74(7):727-9. doi: 10.4065/74.7.727. PMID: 10405705

Prognosis

Tick-Borne Diseases.
Eilbert W, Matella A
Emerg Med Clin North Am 2024 May;42(2):287-302. Epub 2024 Feb 29 doi: 10.1016/j.emc.2024.01.004. PMID: 38641392
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Ocular manifestations of tick-borne diseases.
Raja H, Starr MR, Bakri SJ
Surv Ophthalmol 2016 Nov-Dec;61(6):726-744. Epub 2016 Apr 7 doi: 10.1016/j.survophthal.2016.03.011. PMID: 27060746
Neglected bacterial zoonoses.
Chikeka I, Dumler JS
Clin Microbiol Infect 2015 May;21(5):404-15. Epub 2015 May 8 doi: 10.1016/j.cmi.2015.04.022. PMID: 25964152Free PMC Article
No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever.
Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ
J Pediatr 2015 May;166(5):1246-51. Epub 2015 Mar 17 doi: 10.1016/j.jpeds.2015.02.015. PMID: 25794784

Clinical prediction guides

Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.
Teramoto K, Tamura S, Yoshida K, Inada Y, Yamashita Y, Morimoto M, Mushino T, Koreeda D, Miyamoto K, Komiya N, Nakano Y, Takagaki Y, Koizumi Y
Medicina (Kaunas) 2023 Nov 17;59(11) doi: 10.3390/medicina59112024. PMID: 38004073Free PMC Article
Procedure for spotted fever group Rickettsia isolation from limited clinical blood specimens.
Condit ME, Jones E, Biggerstaff BJ, Kato CY
PLoS Negl Trop Dis 2022 Oct;16(10):e0010781. Epub 2022 Oct 14 doi: 10.1371/journal.pntd.0010781. PMID: 36240222Free PMC Article
Spotted fever group rickettsiae transmitted by Dermacentor ticks and determinants of their spread in Europe.
Buczek W, Koman-Iżko A, Buczek AM, Buczek A, Bartosik K, Kulina D, Ciura D
Ann Agric Environ Med 2020 Dec 22;27(4):505-511. Epub 2020 May 7 doi: 10.26444/aaem/120602. PMID: 33356053
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever.
Todd SR, Dahlgren FS, Traeger MS, Beltrán-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ
J Pediatr 2015 May;166(5):1246-51. Epub 2015 Mar 17 doi: 10.1016/j.jpeds.2015.02.015. PMID: 25794784

Recent systematic reviews

Rickettsiales in the WHO European Region: an update from a One Health perspective.
Guccione C, Colomba C, Iaria C, Cascio A
Parasit Vectors 2023 Jan 30;16(1):41. doi: 10.1186/s13071-022-05646-4. PMID: 36717936Free PMC Article
Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.
Zhang YY, Sun YQ, Chen JJ, Teng AY, Wang T, Li H, Hay SI, Fang LQ, Yang Y, Liu W
Lancet Digit Health 2023 Jan;5(1):e5-e15. Epub 2022 Nov 21 doi: 10.1016/S2589-7500(22)00212-6. PMID: 36424337Free PMC Article
Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review.
Silva-Ramos CR, Hidalgo M, Faccini-Martínez ÁA
Ticks Tick Borne Dis 2021 Jul;12(4):101734. Epub 2021 May 1 doi: 10.1016/j.ttbdis.2021.101734. PMID: 33989945
Israeli Spotted Fever in Sicily. Description of two cases and minireview.
Colomba C, Trizzino M, Giammanco A, Bonura C, Di Bona D, Tolomeo M, Cascio A
Int J Infect Dis 2017 Aug;61:7-12. Epub 2017 Apr 10 doi: 10.1016/j.ijid.2017.04.003. PMID: 28408252
Haemophagocytic syndrome and rickettsial diseases.
Cascio A, Giordano S, Dones P, Venezia S, Iaria C, Ziino O
J Med Microbiol 2011 Apr;60(Pt 4):537-542. Epub 2010 Dec 16 doi: 10.1099/jmm.0.025833-0. PMID: 21163825

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