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Boutonneuse fever

MedGen UID:
14205
•Concept ID:
C0006060
•
Disease or Syndrome
Synonym: Mediterranean spotted fever
SNOMED CT: Mediterranean spotted fever (186774005); Boutonneuse fever (186774005); Marseilles fever (186774005); Fievre boutonneuse (186774005); Tick typhus due to Rickettsia conorii (186774005); Mediterranean tick fever (186774005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0024472
Orphanet: ORPHA83313

Definition

A rare spotted fever rickettsiosis caused by infection with the tick-borne bacterium <i>Rickettsia conorii</i>, characterized by the onset of fever after an incubation period of about a week, followed by a centripetally spreading maculopapular rash, which may evolve into a petechial form. Accompanying symptoms are headaches, myalgia and/or arthralgia, among others. The typical ''tache noire'' may be observed at the site of the tick bite for several days. The disease is endemic in Africa, Southern Europe, and India. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBoutonneuse fever
Follow this link to review classifications for Boutonneuse fever in Orphanet.

Professional guidelines

PubMed

Ofloxacin in the treatment of boutonneuse fever. A preliminary report.
Lecour H, Ferreira O, Cordeiro J, Pereira F, Nogueira A, Sarmento A, Gomes H, Seara A, Resende P
J Chemother 1989 Jul;1(4 Suppl):919-20. PMID: 16312704

Recent clinical studies

Etiology

Mediterranean spotted fever with multiorgan involvement.
Davis K, Ahmado A, Warrell CE, Downs LO, Furneaux J, Sithamparanathan K
BMJ Case Rep 2022 Dec 21;15(12) doi: 10.1136/bcr-2022-249426. PMID: 36543366Free PMC Article
Rickettsial infections of the central nervous system.
Sekeyová Z, Danchenko M, Filipčík P, Fournier PE
PLoS Negl Trop Dis 2019 Aug;13(8):e0007469. Epub 2019 Aug 29 doi: 10.1371/journal.pntd.0007469. PMID: 31465452Free PMC Article
Mediterranean spotted fever.
Rovery C, Raoult D
Infect Dis Clin North Am 2008 Sep;22(3):515-30, ix. doi: 10.1016/j.idc.2008.03.003. PMID: 18755388
Rickettsial diseases in Russia.
Tarasevich IV, Mediannikov OY
Ann N Y Acad Sci 2006 Oct;1078:48-59. doi: 10.1196/annals.1374.006. PMID: 17114680
Epidemiology of rickettsial diseases.
Walker DH, Fishbein DB
Eur J Epidemiol 1991 May;7(3):237-45. doi: 10.1007/BF00145672. PMID: 1884775

Diagnosis

Mediterranean spotted fever.
Brufau-Cochs M, Alamon-Reig F
Med Clin (Barc) 2024 May 31;162(10):e41. Epub 2023 Dec 26 doi: 10.1016/j.medcli.2023.10.028. PMID: 38151367
Rickettsial infections of the central nervous system.
Sekeyová Z, Danchenko M, Filipčík P, Fournier PE
PLoS Negl Trop Dis 2019 Aug;13(8):e0007469. Epub 2019 Aug 29 doi: 10.1371/journal.pntd.0007469. PMID: 31465452Free PMC Article
Clinically-diagnosed Mediterranean Spotted Fever in Malta.
Torpiano P, Pace D
Travel Med Infect Dis 2018 Nov-Dec;26:16-24. Epub 2018 Feb 17 doi: 10.1016/j.tmaid.2018.02.005. PMID: 29462726
Rickettsial meningitis.
Salva I, de Sousa R, Gouveia C
BMJ Case Rep 2014 Mar 10;2014 doi: 10.1136/bcr-2013-203283. PMID: 24614778Free PMC Article
Boutonneuse fever.
Moraga FA, Martinez-Roig A, Alonso JL, Boronat M, Domingo F
Arch Dis Child 1982 Feb;57(2):149-51. doi: 10.1136/adc.57.2.149. PMID: 7065712Free PMC Article

Therapy

Mediterranean spotted fever with multiorgan involvement.
Davis K, Ahmado A, Warrell CE, Downs LO, Furneaux J, Sithamparanathan K
BMJ Case Rep 2022 Dec 21;15(12) doi: 10.1136/bcr-2022-249426. PMID: 36543366Free PMC Article
Clinically-diagnosed Mediterranean Spotted Fever in Malta.
Torpiano P, Pace D
Travel Med Infect Dis 2018 Nov-Dec;26:16-24. Epub 2018 Feb 17 doi: 10.1016/j.tmaid.2018.02.005. PMID: 29462726
Rickettsial meningitis.
Salva I, de Sousa R, Gouveia C
BMJ Case Rep 2014 Mar 10;2014 doi: 10.1136/bcr-2013-203283. PMID: 24614778Free PMC Article
Haemophagocytic syndrome and rickettsial diseases.
Cascio A, Giordano S, Dones P, Venezia S, Iaria C, Ziino O
J Med Microbiol 2011 Apr;60(Pt 4):537-542. Epub 2010 Dec 16 doi: 10.1099/jmm.0.025833-0. PMID: 21163825
Mediterranean spotted fever: a review of fifteen cases.
Mert A, Ozaras R, Tabak F, Bilir M, Ozturk R
J Dermatol 2006 Feb;33(2):103-7. doi: 10.1111/j.1346-8138.2006.00021.x. PMID: 16556276

Prognosis

Mediterranean spotted fever with multiorgan involvement.
Davis K, Ahmado A, Warrell CE, Downs LO, Furneaux J, Sithamparanathan K
BMJ Case Rep 2022 Dec 21;15(12) doi: 10.1136/bcr-2022-249426. PMID: 36543366Free PMC Article
Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015.
Romaní Vidal A, Fernández-Martínez B, Herrador Z, León Gómez I, Gómez Barroso D
Ticks Tick Borne Dis 2020 Mar;11(2):101353. Epub 2019 Dec 3 doi: 10.1016/j.ttbdis.2019.101353. PMID: 31839472
Small Regulatory RNAs of Rickettsia conorii.
Narra HP, Schroeder CL, Sahni A, Rojas M, Khanipov K, Fofanov Y, Sahni SK
Sci Rep 2016 Nov 11;6:36728. doi: 10.1038/srep36728. PMID: 27834404Free PMC Article
Mediterranean spotted fever: a review of fifteen cases.
Mert A, Ozaras R, Tabak F, Bilir M, Ozturk R
J Dermatol 2006 Feb;33(2):103-7. doi: 10.1111/j.1346-8138.2006.00021.x. PMID: 16556276
Rickettsioses of the spotted fever group around the world.
Walker DH
J Dermatol 1989 Jun;16(3):169-77. doi: 10.1111/j.1346-8138.1989.tb01244.x. PMID: 2677080

Clinical prediction guides

Small Regulatory RNAs of Rickettsia conorii.
Narra HP, Schroeder CL, Sahni A, Rojas M, Khanipov K, Fofanov Y, Sahni SK
Sci Rep 2016 Nov 11;6:36728. doi: 10.1038/srep36728. PMID: 27834404Free PMC Article
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine.
Dzelalija B, Punda-Polic V, Medic A, Dobec M
Travel Med Infect Dis 2016 Sep-Oct;14(5):436-443. Epub 2016 Jul 9 doi: 10.1016/j.tmaid.2016.06.010. PMID: 27404664
Imported rickettsioses in Italy.
Beltrame A, Angheben A, Casolari S, Castelli F, Magnani G, Gaiera G, Brillo F, Cattani G, Anselmi M, Tomasoni L, Prati F, Norberto C, Socolovschi C, Bisoffi Z, Raoult D, Parola P
Travel Med Infect Dis 2012 Jul;10(4):201-4. Epub 2012 Jun 26 doi: 10.1016/j.tmaid.2012.05.003. PMID: 22738934
Boutonneuse fever and climate variability.
de Sousa R, Luz T, Parreira P, Santos-Silva M, Bacellar F
Ann N Y Acad Sci 2006 Oct;1078:162-9. doi: 10.1196/annals.1374.029. PMID: 17114701
Mediterranean spotted fever: a review of fifteen cases.
Mert A, Ozaras R, Tabak F, Bilir M, Ozturk R
J Dermatol 2006 Feb;33(2):103-7. doi: 10.1111/j.1346-8138.2006.00021.x. PMID: 16556276

Recent systematic reviews

Under-diagnosis of rickettsial disease in clinical practice: A systematic review.
van Eekeren LE, de Vries SG, Wagenaar JFP, Spijker R, Grobusch MP, Goorhuis A
Travel Med Infect Dis 2018 Nov-Dec;26:7-15. Epub 2018 Mar 2 doi: 10.1016/j.tmaid.2018.02.006. PMID: 29486240
Israeli Spotted Fever in Sicily. Description of two cases and minireview.
Colomba C, Trizzino M, Giammanco A, Bonura C, Di Bona D, Tolomeo M, Cascio A
Int J Infect Dis 2017 Aug;61:7-12. Epub 2017 Apr 10 doi: 10.1016/j.ijid.2017.04.003. PMID: 28408252
Haemophagocytic syndrome and rickettsial diseases.
Cascio A, Giordano S, Dones P, Venezia S, Iaria C, Ziino O
J Med Microbiol 2011 Apr;60(Pt 4):537-542. Epub 2010 Dec 16 doi: 10.1099/jmm.0.025833-0. PMID: 21163825

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