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Yaws

MedGen UID:
12186
•Concept ID:
C0043388
•
Disease or Syndrome
Synonyms: Endemic treponematoses; Frambesia; Frambesia tropica; Treponema pertenue infection
SNOMED CT: Yaws (70647001); Frambesia (70647001); Pian (70647001); Buba (70647001); Infection by Treponema pertenue (70647001)
 
Monarch Initiative: MONDO:0006019

Definition

An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease. [from NCI]

Professional guidelines

PubMed

The historical differential diagnosis of the disease that afflicted Aleijadinho, the famous 18th century Brazilian sculptor.
Sohler RP, DE Lima LS, Zatta VZ, Chambriard CJ, DE Freitas MRG
Arq Neuropsiquiatr 2021 Dec;79(12):1138-1144. doi: 10.1590/0004-282X-ANP-2021-0014. PMID: 34877986
Modeling Treatment Strategies to Inform Yaws Eradication.
Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L
Emerg Infect Dis 2020 Nov;26(11):2685-2693. doi: 10.3201/eid2611.191491. PMID: 33079046Free PMC Article
New treatment schemes for yaws: the path toward eradication.
Mitjà O, Hays R, Rinaldi AC, McDermott R, Bassat Q
Clin Infect Dis 2012 Aug;55(3):406-12. Epub 2012 May 18 doi: 10.1093/cid/cis444. PMID: 22610931

Recent clinical studies

Etiology

The current status of neglected tropical diseases in Japan: A scoping review.
Harada Y, Iwashita H, Moriyasu T, Nagi S, Saito N, Sugawara-Mikami M, Yoshioka K, Yotsu R; Japan NTD Study Group
PLoS Negl Trop Dis 2024 Jan;18(1):e0011854. Epub 2024 Jan 2 doi: 10.1371/journal.pntd.0011854. PMID: 38166156Free PMC Article
Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.
Zhang Y, Goh SM, Mello MB, Baggaley RC, Wi T, Johnson CC, Asiedu KB, Marks M, Pham MD, Fairley CK, Chow EPF, Mitjà O, Toskin I, Ballard RC, Ong JJ
Sex Transm Infect 2022 Dec;98(8):608-616. Epub 2022 Sep 30 doi: 10.1136/sextrans-2022-055546. PMID: 36180209Free PMC Article
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Global epidemiology of yaws: a systematic review.
Mitjà O, Marks M, Konan DJ, Ayelo G, Gonzalez-Beiras C, Boua B, Houinei W, Kobara Y, Tabah EN, Nsiire A, Obvala D, Taleo F, Djupuri R, Zaixing Z, Utzinger J, Vestergaard LS, Bassat Q, Asiedu K
Lancet Glob Health 2015 Jun;3(6):e324-31. doi: 10.1016/S2214-109X(15)00011-X. PMID: 26001576Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556

Diagnosis

Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Yaws.
Marks M, Mitjà O, Solomon AW, Asiedu KB, Mabey DC
Br Med Bull 2015;113(1):91-100. Epub 2014 Dec 18 doi: 10.1093/bmb/ldu037. PMID: 25525120Free PMC Article
Yaws.
Marks M, Lebari D, Solomon AW, Higgins SP
Int J STD AIDS 2015 Sep;26(10):696-703. Epub 2014 Sep 4 doi: 10.1177/0956462414549036. PMID: 25193248Free PMC Article
Yaws.
Mitjà O, Asiedu K, Mabey D
Lancet 2013 Mar 2;381(9868):763-73. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62130-8. PMID: 23415015
History of syphilis.
Rothschild BM
Clin Infect Dis 2005 May 15;40(10):1454-63. Epub 2005 Apr 1 doi: 10.1086/429626. PMID: 15844068

Therapy

The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.
Pfarr KM, Krome AK, Al-Obaidi I, Batchelor H, Vaillant M, Hoerauf A, Opoku NO, Kuesel AC
Parasit Vectors 2023 Oct 31;16(1):394. doi: 10.1186/s13071-023-05909-8. PMID: 37907954Free PMC Article
Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Yaws.
Marks M, Mitjà O, Solomon AW, Asiedu KB, Mabey DC
Br Med Bull 2015;113(1):91-100. Epub 2014 Dec 18 doi: 10.1093/bmb/ldu037. PMID: 25525120Free PMC Article
Yaws.
Marks M, Lebari D, Solomon AW, Higgins SP
Int J STD AIDS 2015 Sep;26(10):696-703. Epub 2014 Sep 4 doi: 10.1177/0956462414549036. PMID: 25193248Free PMC Article
Yaws.
Mitjà O, Asiedu K, Mabey D
Lancet 2013 Mar 2;381(9868):763-73. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62130-8. PMID: 23415015

Prognosis

Modeling Treatment Strategies to Inform Yaws Eradication.
Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L
Emerg Infect Dis 2020 Nov;26(11):2685-2693. doi: 10.3201/eid2611.191491. PMID: 33079046Free PMC Article
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Congenital Syphilis in Honiara, Solomon Islands.
Lifigao M, Nasi T, Titiulu C, Lumasa S, Duke T
J Trop Pediatr 2020 Dec 1;66(6):583-588. doi: 10.1093/tropej/fmaa017. PMID: 32361735
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
The return of yaws.
Asiedu K
Bull World Health Organ 2008 Jul;86(7):507-8. doi: 10.2471/blt.08.040708. PMID: 18670660Free PMC Article

Clinical prediction guides

Deep learning for AI-based diagnosis of skin-related neglected tropical diseases: A pilot study.
Yotsu RR, Ding Z, Hamm J, Blanton RE
PLoS Negl Trop Dis 2023 Aug;17(8):e0011230. Epub 2023 Aug 14 doi: 10.1371/journal.pntd.0011230. PMID: 37578966Free PMC Article
Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks.
Rolfe RJ, Shaikh H, Tillekeratne LG
Infect Dis Poverty 2022 Jun 30;11(1):77. doi: 10.1186/s40249-022-00998-6. PMID: 35773722Free PMC Article
Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study.
Simpson H, Tabah EN, Phillips RO, Frimpong M, Maman I, Ampadu E, Timothy J, Saunderson P, Pullan RL, Cano J
PLoS Negl Trop Dis 2021 Mar;15(3):e0009157. Epub 2021 Mar 3 doi: 10.1371/journal.pntd.0009157. PMID: 33657104Free PMC Article
Modeling Treatment Strategies to Inform Yaws Eradication.
Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L
Emerg Infect Dis 2020 Nov;26(11):2685-2693. doi: 10.3201/eid2611.191491. PMID: 33079046Free PMC Article
Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen.
Lewis DA, Mitjà O
Curr Opin Infect Dis 2016 Feb;29(1):52-7. doi: 10.1097/QCO.0000000000000226. PMID: 26658654

Recent systematic reviews

Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.
Zhang Y, Goh SM, Mello MB, Baggaley RC, Wi T, Johnson CC, Asiedu KB, Marks M, Pham MD, Fairley CK, Chow EPF, Mitjà O, Toskin I, Ballard RC, Ong JJ
Sex Transm Infect 2022 Dec;98(8):608-616. Epub 2022 Sep 30 doi: 10.1136/sextrans-2022-055546. PMID: 36180209Free PMC Article
Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis.
Li J, Xiong T, Yue Y, Choonara I, Qazi S, Tang J, Shi J, Wang H, Qu Y, Mu D
Am J Trop Med Hyg 2022 Oct 12;107(4):904-911. Epub 2022 Aug 15 doi: 10.4269/ajtmh.22-0134. PMID: 35970284Free PMC Article
Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J
Lancet Glob Health 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890Free PMC Article
Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.
Zoni AC, Saboyá-Díaz MI, Castellanos LG, Nicholls RS, Blaya-Novakova V
PLoS Negl Trop Dis 2019 Feb;13(2):e0007125. Epub 2019 Feb 25 doi: 10.1371/journal.pntd.0007125. PMID: 30802249Free PMC Article
Global epidemiology of yaws: a systematic review.
Mitjà O, Marks M, Konan DJ, Ayelo G, Gonzalez-Beiras C, Boua B, Houinei W, Kobara Y, Tabah EN, Nsiire A, Obvala D, Taleo F, Djupuri R, Zaixing Z, Utzinger J, Vestergaard LS, Bassat Q, Asiedu K
Lancet Glob Health 2015 Jun;3(6):e324-31. doi: 10.1016/S2214-109X(15)00011-X. PMID: 26001576Free PMC Article

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