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Early yaws

MedGen UID:
124440
•Concept ID:
C0275998
•
Disease or Syndrome
Synonyms: bone and joint lesions due to yaws; bone and joint yaws lesion; chancre of yaws; Early Yaws; early yaws; frambesia, initial or primary; initial frambesial ulcer; initial lesions of yaws; primary frambesia
SNOMED CT: Early yaws (23191004)
 
Monarch Initiative: MONDO:0001067

Definition

Early yaws includes primary and secondary stages of yaws, endemic tropical treponemal nonvenereal infection: development of initial lesion at inoculation site followed by widespread dissemination of treponemes and generalized secondary granulomatous lesions that may relapse repeatedly. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly yaws

Professional guidelines

PubMed

Importance of consultations using mobile teams in the screening and treatment of neglected tropical skin diseases in Benin.
Gnimavo RS, Fajloun F, Al-Bayssari C, Sodjinou E, Habib A, Ganlonon L, Claco E, Agoundoté I, Houngbo OA, Anagonou EG, Biaou CAO, Ayélo AG, Houezo JG, Boccarossa A, Moussa EH, Gomez B, Gine A, Sopoh GE, Marion E, Johnson RC, Kempf M
PLoS Negl Trop Dis 2023 May;17(5):e0011314. Epub 2023 May 12 doi: 10.1371/journal.pntd.0011314. PMID: 37172044Free PMC Article
The development, implementation, and evaluation of an optimal model for the case detection, referral, and case management of Neglected Tropical Diseases.
Godwin-Akpan TG, Chowdhury S, Rogers EJ, Kollie KK, Zaizay FZ, Wickenden A, Zawolo GVK, Parker CBMC, Dean L
PLoS One 2023;18(5):e0283856. Epub 2023 May 10 doi: 10.1371/journal.pone.0283856. PMID: 37163515Free PMC Article
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.
Abdulai AA, Agana-Nsiire P, Biney F, Kwakye-Maclean C, Kyei-Faried S, Amponsa-Achiano K, Simpson SV, Bonsu G, Ohene SA, Ampofo WK, Adu-Sarkodie Y, Addo KK, Chi KH, Danavall D, Chen CY, Pillay A, Sanz S, Tun Y, Mitjà O, Asiedu KB, Ballard RC
PLoS Negl Trop Dis 2018 Mar;12(3):e0006303. Epub 2018 Mar 22 doi: 10.1371/journal.pntd.0006303. PMID: 29566044Free PMC Article

Recent clinical studies

Etiology

A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana.
Kwakye-Maclean C, Agana N, Gyapong J, Nortey P, Adu-Sarkodie Y, Aryee E, Asiedu K, Ballard R, Binka F
PLoS Negl Trop Dis 2017 Jan;11(1):e0005154. Epub 2017 Jan 10 doi: 10.1371/journal.pntd.0005154. PMID: 28072863Free PMC Article
Fluctuations in antibody levels in infection with Treponema pertenue. A four-year follow-up of Karkar islanders with early yaws.
Reid MS, Talwat EN, McNamara KM, Garner MF
Australas J Dermatol 1983 Aug;24(2):71-8. doi: 10.1111/j.1440-0960.1983.tb00255.x. PMID: 6661116

Diagnosis

Osteoperiostitis in early yaws: case series and literature review.
Mitjà O, Hays R, Ipai A, Wau B, Bassat Q
Clin Infect Dis 2011 Mar 15;52(6):771-4. doi: 10.1093/cid/ciq246. PMID: 21367729
Early yaws: a light microscopic study.
Engelkens HJ, Vuzevski VD, Judanarso J, van Lier JB, van der Stek J, van der Sluis JJ, Stolz E
Genitourin Med 1990 Aug;66(4):264-6. doi: 10.1136/sti.66.4.264. PMID: 2391114Free PMC Article
Radiological and dermatological findings in two patients suffering from early yaws in Indonesia.
Engelkens HJ, Ginai AZ, Judanarso J, Kasim C, van der Stek J, van der Sluis JJ, Stolz E
Genitourin Med 1990 Aug;66(4):259-63. doi: 10.1136/sti.66.4.259. PMID: 2391113Free PMC Article
Case for diagnosis. Disseminated (early) yaws.
Mil Med 1981 Nov;146(11):802, 807-8. PMID: 6798505
Early yaws.
Fry L, Rodin P
Br J Vener Dis 1966 Mar;42(1):28-30. doi: 10.1136/sti.42.1.28. PMID: 5929695Free PMC Article

Therapy

A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana.
Kwakye-Maclean C, Agana N, Gyapong J, Nortey P, Adu-Sarkodie Y, Aryee E, Asiedu K, Ballard R, Binka F
PLoS Negl Trop Dis 2017 Jan;11(1):e0005154. Epub 2017 Jan 10 doi: 10.1371/journal.pntd.0005154. PMID: 28072863Free PMC Article
Osteoperiostitis in early yaws: case series and literature review.
Mitjà O, Hays R, Ipai A, Wau B, Bassat Q
Clin Infect Dis 2011 Mar 15;52(6):771-4. doi: 10.1093/cid/ciq246. PMID: 21367729
Radiological and dermatological findings in two patients suffering from early yaws in Indonesia.
Engelkens HJ, Ginai AZ, Judanarso J, Kasim C, van der Stek J, van der Sluis JJ, Stolz E
Genitourin Med 1990 Aug;66(4):259-63. doi: 10.1136/sti.66.4.259. PMID: 2391113Free PMC Article
Disseminated early yaws: report of a child with a remarkable genital lesion mimicking venereal syphilis.
Engelkens HJ, Judanarso J, van der Sluis JJ, van der Stek J, Stolz E
Pediatr Dermatol 1990 Mar;7(1):60-2. doi: 10.1111/j.1525-1470.1990.tb01076.x. PMID: 2343008
Early yaws.
Fry L, Rodin P
Br J Vener Dis 1966 Mar;42(1):28-30. doi: 10.1136/sti.42.1.28. PMID: 5929695Free PMC Article

Prognosis

Fluctuations in antibody levels in infection with Treponema pertenue. A four-year follow-up of Karkar islanders with early yaws.
Reid MS, Talwat EN, McNamara KM, Garner MF
Australas J Dermatol 1983 Aug;24(2):71-8. doi: 10.1111/j.1440-0960.1983.tb00255.x. PMID: 6661116

Clinical prediction guides

Early yaws: a light microscopic study.
Engelkens HJ, Vuzevski VD, Judanarso J, van Lier JB, van der Stek J, van der Sluis JJ, Stolz E
Genitourin Med 1990 Aug;66(4):264-6. doi: 10.1136/sti.66.4.264. PMID: 2391114Free PMC Article

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