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Benign neoplasm of ciliary body

MedGen UID:
96927
•Concept ID:
C0496894
•
Neoplastic Process
Synonyms: Benign Ciliary Body Neoplasm; benign ciliary body neoplasm; Benign Ciliary Body Tumor; benign ciliary body tumor; benign ciliary body tumour; Benign Neoplasm of Ciliary Body; benign neoplasm of ciliary body; Benign Neoplasm of the Ciliary Body; benign neoplasm of the ciliary body; Benign tumor of ciliary body; Benign Tumor of Ciliary Body; benign tumor of ciliary body; Benign Tumor of the Ciliary Body; benign tumor of the ciliary body; benign tumour of ciliary body; benign tumour of the ciliary body; ciliary body benign neoplasm
SNOMED CT: Benign tumor of ciliary body (92060009); Benign neoplasm of ciliary body (92060009)
 
Monarch Initiative: MONDO:0021486

Definition

A neoplasm that arises from the ciliary body and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Robotic CyberKnife Radiosurgery for Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Foerster MH, Muacevic A, Priglinger SG, Schaller UC, Foerster P
Ophthalmol Retina 2020 Sep;4(9):954-956. Epub 2020 Apr 20 doi: 10.1016/j.oret.2020.03.031. PMID: 32595095
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Orbital melanoma.
Furdova A, Chynoransky M, Krajcova P
Bratisl Lek Listy 2011;112(8):466-8. PMID: 21863619
Preoperative evaluation for patients with choroidal/ciliary body melanomas: what is necessary?
Wykoff CC, Murray TG, Markoe AM, Feun LG, Schefler AC, Gayer S
Am J Ophthalmol 2011 Jun;151(6):921-4. doi: 10.1016/j.ajo.2011.01.050. PMID: 21616209

Diagnosis

Ciliary Body Perivascular Epithelioid Cell Tumor.
Simms K, Tiwari N, Ramasubramanian A
Ophthalmology 2024 May;131(5):621. Epub 2023 Sep 14 doi: 10.1016/j.ophtha.2023.08.009. PMID: 37702634
Lenticular Anomaly Masking as a Ciliary Body Cyst.
Lewis K, Gombos DS, Saboo US
Ophthalmology 2023 Dec;130(12):1347. Epub 2023 Feb 14 doi: 10.1016/j.ophtha.2023.01.012. PMID: 36792448
Medulloepithelioma in newborn: Advanced clinical status.
Barchitta M, De Francesco S, Menicacci C, Girolamo MM, Salvoldi F, Hadjistilianou D
Eur J Ophthalmol 2022 Nov;32(6):NP73-NP77. Epub 2021 May 31 doi: 10.1177/11206721211019579. PMID: 34053319
Melanomalytic Glaucoma.
Burris CK, Rodriguez ME, Raven ML
Ophthalmology 2015 Dec;122(12):2422. doi: 10.1016/j.ophtha.2015.09.006. PMID: 26592671
Paediatric uveal melanoma.
Kanthan GL, Grigg J, Billson F, Kourt G, Conway RM
Clin Exp Ophthalmol 2008 May;36(4):374-6. doi: 10.1111/j.1442-9071.2008.001739.x. PMID: 18700927

Therapy

Necrosis of uveal melanoma post-COVID-19 vaccination.
Wagle AM, Wu BC, Gopal L, Sundar G
Indian J Ophthalmol 2022 May;70(5):1837-1840. doi: 10.4103/ijo.IJO_3040_21. PMID: 35502089Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Presumed bilateral medulloepithelioma.
Lumbroso L, Desjardins L, Coue O, Ducourneau Y, Pechereau A
Arch Ophthalmol 2001 Mar;119(3):449-50. PMID: 11231783
Biomicroscopy of the peripheral fundus.
Eisner G
Surv Ophthalmol 1972 Jul-Aug;17(1):1-28. PMID: 4606275
MEDULLO-EPITHELIOMA.
Sayed BA, Sahgal KN, Desai VK
Br J Ophthalmol 1962 Jan;46(1):58-60. doi: 10.1136/bjo.46.1.58. PMID: 18170756Free PMC Article

Prognosis

DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Paediatric uveal melanoma.
Kanthan GL, Grigg J, Billson F, Kourt G, Conway RM
Clin Exp Ophthalmol 2008 May;36(4):374-6. doi: 10.1111/j.1442-9071.2008.001739.x. PMID: 18700927
Ocular melanoma.
Grin-Jorgensen C, Berke A, Grin M
Dermatol Clin 1992 Oct;10(4):663-8. PMID: 1395150

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Retinopathy from a green laser pointer: a clinicopathologic study.
Robertson DM, McLaren JW, Salomao DR, Link TP
Arch Ophthalmol 2005 May;123(5):629-33. doi: 10.1001/archopht.123.5.629. PMID: 15883281
Ciliochoroidal effusion induced by topical latanoprost in a patient with sturge-weber syndrome.
Sakai H, Sakima N, Nakamura Y, Nakamura Y, Hayakawa K, Sawaguchi S
Jpn J Ophthalmol 2002 Sep-Oct;46(5):553-5. doi: 10.1016/s0021-5155(02)00542-7. PMID: 12457915

Recent systematic reviews

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma.
Messineo D, Barile G, Morrone S, La Torre G, Turchetti P, Accetta L, Trovato Battagliola E, Agostinelli E, Pacella F
Clin Ter 2020 Jan-Feb;170(1):e89-e98. doi: 10.7417/CT.2020.2195. PMID: 31916427
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Diagnostic performance of magnetic resonance imaging and computed tomography for advanced retinoblastoma: a systematic review and meta-analysis.
de Jong MC, de Graaf P, Noij DP, Göricke S, Maeder P, Galluzzi P, Brisse HJ, Moll AC, Castelijns JA; European Retinoblastoma Imaging Collaboration (ERIC)
Ophthalmology 2014 May;121(5):1109-18. Epub 2014 Mar 1 doi: 10.1016/j.ophtha.2013.11.021. PMID: 24589388
Uveal melanoma: trends in incidence, treatment, and survival.
Singh AD, Turell ME, Topham AK
Ophthalmology 2011 Sep;118(9):1881-5. Epub 2011 Jun 24 doi: 10.1016/j.ophtha.2011.01.040. PMID: 21704381

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