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Depressed Level Of Consciousness

MedGen UID:
108194
•Concept ID:
C0549249
•
Finding
Synonyms: Consciousness, Level Depressed; Depressed Level of Consciousness

Definition

A neurologic state characterized by decreased ability to perceive and respond. [from NCI]

Professional guidelines

PubMed

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Encephalitis diagnosis and management in the real world.
Long SS
Adv Exp Med Biol 2011;697:153-73. doi: 10.1007/978-1-4419-7185-2_11. PMID: 21120725
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ
Hematol Oncol Clin North Am 2009 Oct;23(5):1121-35, vii-viii. doi: 10.1016/j.hoc.2009.07.008. PMID: 19825456

Recent clinical studies

Etiology

In-Hospital Depressed Level of Consciousness and Long-Term Functional Outcomes in ICU Survivors.
Mart MF, Thompson JL, Ely EW, Pandharipande PP, Patel MB, Wilson JE, Williams Roberson S, Birdrow CI, Raman R, Brummel NE
Crit Care Med 2022 Nov 1;50(11):1618-1627. Epub 2022 Aug 23 doi: 10.1097/CCM.0000000000005656. PMID: 36005816Free PMC Article
Predictors of mortality in older patients admitted to a geriatric hospital.
Agrawal S, Luc M, Winkowski F, Lindner K, Agrawal AK, Wozniak M, Sobieszczanska M
Geriatr Gerontol Int 2019 Jan;19(1):70-75. Epub 2018 Nov 22 doi: 10.1111/ggi.13573. PMID: 30565834
Electrographic Seizures in Patients with Acute Encephalitis.
Viarasilpa T, Panyavachiraporn N, Osman G, Parres C, Varelas P, Van Harn M, Mayer SA
Neurocrit Care 2019 Feb;30(1):207-215. doi: 10.1007/s12028-018-0599-4. PMID: 30203384
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Cerebrovascular disorders.
Hutchison JS, Ichord R, Guerguerian AM, Deveber G
Semin Pediatr Neurol 2004 Jun;11(2):139-46. doi: 10.1016/j.spen.2004.04.004. PMID: 15259867

Diagnosis

Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ
Hematol Oncol Clin North Am 2009 Oct;23(5):1121-35, vii-viii. doi: 10.1016/j.hoc.2009.07.008. PMID: 19825456
The floppy infant: evaluation of hypotonia.
Peredo DE, Hannibal MC
Pediatr Rev 2009 Sep;30(9):e66-76. doi: 10.1542/pir.30-9-e66. PMID: 19726697
Cerebrovascular disorders.
Hutchison JS, Ichord R, Guerguerian AM, Deveber G
Semin Pediatr Neurol 2004 Jun;11(2):139-46. doi: 10.1016/j.spen.2004.04.004. PMID: 15259867
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746
Epidemiology of nosocomial pneumonia in intensive care unit patients.
George DL
Clin Chest Med 1995 Mar;16(1):29-44. PMID: 7768093

Therapy

A Real-World Pharmacovigilance Study of Ceftazidime/Avibactam: Data Mining of the Food and Drug Administration Adverse Event Reporting System Database.
Yao H, Wang Y, Peng Y, Huang Z, Gan G, Wang Z
J Clin Pharmacol 2024 Jul;64(7):820-827. Epub 2024 Feb 20 doi: 10.1002/jcph.2420. PMID: 38375685
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus.
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen TL, Halsey C, Hough R, Jeha S, Kato M, Liang DC, Mikkelsen TS, Möricke A, Niinimäki R, Piette C, Putti MC, Raetz E, Silverman LB, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E; Ponte di Legno toxicity working group
Lancet Oncol 2016 Jun;17(6):e231-e239. doi: 10.1016/S1470-2045(16)30035-3. PMID: 27299279
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma.
DeAngelo DJ
Hematol Oncol Clin North Am 2009 Oct;23(5):1121-35, vii-viii. doi: 10.1016/j.hoc.2009.07.008. PMID: 19825456
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746
Epidemiology of nosocomial pneumonia in intensive care unit patients.
George DL
Clin Chest Med 1995 Mar;16(1):29-44. PMID: 7768093

Prognosis

Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial.
Coleman R, Finkelstein DM, Barrios C, Martin M, Iwata H, Hegg R, Glaspy J, Periañez AM, Tonkin K, Deleu I, Sohn J, Crown J, Delaloge S, Dai T, Zhou Y, Jandial D, Chan A
Lancet Oncol 2020 Jan;21(1):60-72. Epub 2019 Dec 2 doi: 10.1016/S1470-2045(19)30687-4. PMID: 31806543
Predictors of mortality in older patients admitted to a geriatric hospital.
Agrawal S, Luc M, Winkowski F, Lindner K, Agrawal AK, Wozniak M, Sobieszczanska M
Geriatr Gerontol Int 2019 Jan;19(1):70-75. Epub 2018 Nov 22 doi: 10.1111/ggi.13573. PMID: 30565834
Avalanche trauma and closed head injury: adding insult to injury.
Johnson SM, Johnson AC, Barton RG
Wilderness Environ Med 2001 Winter;12(4):244-7. doi: 10.1580/1080-6032(2001)012[0244:atachi]2.0.co;2. PMID: 11769920
Pneumococcal sacroiliitis.
Pinson AG, Jolles PR, Balkissoon AR
South Med J 1997 Jun;90(6):649-52. doi: 10.1097/00007611-199706000-00015. PMID: 9191746
Epidemiology of nosocomial pneumonia in intensive care unit patients.
George DL
Clin Chest Med 1995 Mar;16(1):29-44. PMID: 7768093

Clinical prediction guides

In-Hospital Depressed Level of Consciousness and Long-Term Functional Outcomes in ICU Survivors.
Mart MF, Thompson JL, Ely EW, Pandharipande PP, Patel MB, Wilson JE, Williams Roberson S, Birdrow CI, Raman R, Brummel NE
Crit Care Med 2022 Nov 1;50(11):1618-1627. Epub 2022 Aug 23 doi: 10.1097/CCM.0000000000005656. PMID: 36005816Free PMC Article
Predictors of mortality in older patients admitted to a geriatric hospital.
Agrawal S, Luc M, Winkowski F, Lindner K, Agrawal AK, Wozniak M, Sobieszczanska M
Geriatr Gerontol Int 2019 Jan;19(1):70-75. Epub 2018 Nov 22 doi: 10.1111/ggi.13573. PMID: 30565834
Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions.
Tejada JG, Taylor RA, Ugurel MS, Hayakawa M, Lee SK, Chaloupka JC
AJNR Am J Neuroradiol 2007 May;28(5):844-8. PMID: 17494654Free PMC Article
Pediatric infratentorial subdural empyema: analysis of 14 cases.
Venkatesh MS, Pandey P, Devi BI, Khanapure K, Satish S, Sampath S, Chandramouli BA, Sastry KV
J Neurosurg 2006 Nov;105(5 Suppl):370-7. doi: 10.3171/ped.2006.105.5.370. PMID: 17328260
Brain abscesses--the Groote Schuur experience, 1993-2003.
Sichizya K, Fieggen G, Taylor A, Peter J
S Afr J Surg 2005 Aug;43(3):79-82. PMID: 16180392

Recent systematic reviews

Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.
Kupats E, Vrublevska J, Zvejniece B, Vavers E, Stelfa G, Zvejniece L, Dambrova M
Pharmacopsychiatry 2020 Sep;53(5):201-208. Epub 2020 Apr 27 doi: 10.1055/a-1151-5017. PMID: 32340063
The Full Outline of UnResponsiveness (FOUR) Score and Its Use in Outcome Prediction: A Scoping Systematic Review of the Adult Literature.
Almojuela A, Hasen M, Zeiler FA
Neurocrit Care 2019 Aug;31(1):162-175. doi: 10.1007/s12028-018-0630-9. PMID: 30411302

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