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Acute Myeloid Leukemia with FLT3/ITD Mutation

MedGen UID:
927531
Concept ID:
C4289999
Neoplastic Process

Definition

Acute myeloid leukemia characterized by the presence of a FLT3-internal tandem duplication (ITD) mutation. Patients with this mutation usually present with more aggressive disease and have higher rates of relapse after remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia with FLT3/ITD Mutation

Professional guidelines

PubMed

Mihaila RG, Topircean D
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Sep;165(3):249-257. Epub 2021 Aug 24 doi: 10.5507/bp.2021.048. PMID: 34446939

Recent clinical studies

Etiology

Bystrom R, Levis MJ
Curr Oncol Rep 2023 Apr;25(4):369-378. Epub 2023 Feb 18 doi: 10.1007/s11912-023-01389-2. PMID: 36808557
Döhner H, Wei AH, Roboz GJ, Montesinos P, Thol FR, Ravandi F, Dombret H, Porkka K, Sandhu I, Skikne B, See WL, Ugidos M, Risueño A, Chan ET, Thakurta A, Beach CL, Lopes de Menezes D
Blood 2022 Oct 13;140(15):1674-1685. doi: 10.1182/blood.2022016293. PMID: 35960871Free PMC Article
Schmalbrock LK, Dolnik A, Cocciardi S, Sträng E, Theis F, Jahn N, Panina E, Blätte TJ, Herzig J, Skambraks S, Rücker FG, Gaidzik VI, Paschka P, Fiedler W, Salih HR, Wulf G, Schroeder T, Lübbert M, Schlenk RF, Thol F, Heuser M, Larson RA, Ganser A, Stunnenberg HG, Minucci S, Stone RM, Bloomfield CD, Döhner H, Döhner K, Bullinger L
Blood 2021 Jun 3;137(22):3093-3104. doi: 10.1182/blood.2020007626. PMID: 33598693Free PMC Article
De Kouchkovsky I, Abdul-Hay M
Blood Cancer J 2016 Jul 1;6(7):e441. doi: 10.1038/bcj.2016.50. PMID: 27367478Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Diagnosis

Tiong IS, Loo S
Int J Mol Sci 2023 Mar 1;24(5) doi: 10.3390/ijms24054790. PMID: 36902217Free PMC Article
Grob T, Sanders MA, Vonk CM, Kavelaars FG, Rijken M, Hanekamp DW, Gradowska PL, Cloos J, Fløisand Y, van Marwijk Kooy M, Manz MG, Ossenkoppele GJ, Tick LW, Havelange V, Löwenberg B, Jongen-Lavrencic M, Valk PJM
J Clin Oncol 2023 Feb 1;41(4):756-765. Epub 2022 Oct 31 doi: 10.1200/JCO.22.00715. PMID: 36315929Free PMC Article
Daver N, Venugopal S, Ravandi F
Blood Cancer J 2021 May 27;11(5):104. doi: 10.1038/s41408-021-00495-3. PMID: 34045454Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
De Kouchkovsky I, Abdul-Hay M
Blood Cancer J 2016 Jul 1;6(7):e441. doi: 10.1038/bcj.2016.50. PMID: 27367478Free PMC Article

Therapy

Erba HP, Montesinos P, Kim HJ, Patkowska E, Vrhovac R, Žák P, Wang PN, Mitov T, Hanyok J, Kamel YM, Rohrbach JEC, Liu L, Benzohra A, Lesegretain A, Cortes J, Perl AE, Sekeres MA, Dombret H, Amadori S, Wang J, Levis MJ, Schlenk RF; QuANTUM-First Study Group
Lancet 2023 May 13;401(10388):1571-1583. Epub 2023 Apr 25 doi: 10.1016/S0140-6736(23)00464-6. PMID: 37116523
Daver N, Venugopal S, Ravandi F
Blood Cancer J 2021 May 27;11(5):104. doi: 10.1038/s41408-021-00495-3. PMID: 34045454Free PMC Article
Burchert A
Haematologica 2021 Mar 1;106(3):664-670. doi: 10.3324/haematol.2019.240747. PMID: 33472354Free PMC Article
Kiyoi H, Kawashima N, Ishikawa Y
Cancer Sci 2020 Feb;111(2):312-322. Epub 2019 Dec 30 doi: 10.1111/cas.14274. PMID: 31821677Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article

Prognosis

Bystrom R, Levis MJ
Curr Oncol Rep 2023 Apr;25(4):369-378. Epub 2023 Feb 18 doi: 10.1007/s11912-023-01389-2. PMID: 36808557
Daver N, Venugopal S, Ravandi F
Blood Cancer J 2021 May 27;11(5):104. doi: 10.1038/s41408-021-00495-3. PMID: 34045454Free PMC Article
Burchert A
Haematologica 2021 Mar 1;106(3):664-670. doi: 10.3324/haematol.2019.240747. PMID: 33472354Free PMC Article
Kiyoi H, Kawashima N, Ishikawa Y
Cancer Sci 2020 Feb;111(2):312-322. Epub 2019 Dec 30 doi: 10.1111/cas.14274. PMID: 31821677Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article

Clinical prediction guides

Tiong IS, Loo S
Int J Mol Sci 2023 Mar 1;24(5) doi: 10.3390/ijms24054790. PMID: 36902217Free PMC Article
Padella A, Ghelli Luserna Di Rorà A, Marconi G, Ghetti M, Martinelli G, Simonetti G
J Hematol Oncol 2022 Jan 22;15(1):10. doi: 10.1186/s13045-022-01228-0. PMID: 35065680Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Recent systematic reviews

Srinivasan S, Kumar S, Vijayasekharan K, Agrawal AK
Clin Lymphoma Myeloma Leuk 2022 Apr;22(4):e221-e232. Epub 2021 Oct 2 doi: 10.1016/j.clml.2021.09.020. PMID: 34750085
Gagelmann N, Wolschke C, Klyuchnikov E, Christopeit M, Ayuk F, Kröger N
Front Immunol 2021;12:630429. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.630429. PMID: 33790903Free PMC Article
Rinaldi I, Louisa M, Wiguna FI, Budiani E, Mahardhika JC, Hukmi K
Asian Pac J Cancer Prev 2020 Oct 1;21(10):2827-2836. doi: 10.31557/APJCP.2020.21.10.2827. PMID: 33112537Free PMC Article
Megías-Vericat JE, Martínez-Cuadrón D, Sanz MÁ, Poveda JL, Montesinos P
Expert Rev Clin Pharmacol 2019 Mar;12(3):197-218. Epub 2019 Feb 6 doi: 10.1080/17512433.2019.1573668. PMID: 30672340
Port M, Böttcher M, Thol F, Ganser A, Schlenk R, Wasem J, Neumann A, Pouryamout L
Ann Hematol 2014 Aug;93(8):1279-86. Epub 2014 May 7 doi: 10.1007/s00277-014-2072-6. PMID: 24801015

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