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Recurrent Gastrointestinal Stromal Tumor

MedGen UID:
925838
•Concept ID:
C4288306
•
Neoplastic Process

Definition

The reemergence of a gastrointestinal stromal tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Preoperative imatinib for patients with primary unresectable or metastatic/recurrent gastrointestinal stromal tumor.
Shen C, Chen H, Yin Y, Chen J, Zhang B, Chen Z, Chen J
Clinics (Sao Paulo) 2014 Nov;69(11):758-62. doi: 10.6061/clinics/2014(11)09. PMID: 25518034Free PMC Article
A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome.
Zhu J, Yang Y, Zhou L, Jiang M, Hou M
BMC Cancer 2010 May 13;10:199. doi: 10.1186/1471-2407-10-199. PMID: 20465813Free PMC Article

Recent clinical studies

Etiology

Disease-free Interval Is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor.
Sutton TL, Walker BS, Billingsley KG, Sheppard BC, Corless CL, Heinrich MC, Mayo SC
Ann Surg Oncol 2021 Nov;28(12):7912-7920. Epub 2021 May 9 doi: 10.1245/s10434-021-10062-6. PMID: 33969462
Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM
Cell Cycle 2018;17(6):722-727. doi: 10.1080/15384101.2017.1423223. PMID: 29334307Free PMC Article
Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor.
Jiang D, He D, Hou Y, Lu W, Shi Y, Hu Q, Lu S, Xu C, Liu Y, Liu J, Tan Y, Zhu X
Diagn Pathol 2013 Jul 31;8:125. doi: 10.1186/1746-1596-8-125. PMID: 23902675Free PMC Article
A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome.
Zhu J, Yang Y, Zhou L, Jiang M, Hou M
BMC Cancer 2010 May 13;10:199. doi: 10.1186/1471-2407-10-199. PMID: 20465813Free PMC Article
Emergence of imatinib resistance associated with downregulation of c-kit expression in recurrent gastrointestinal stromal tumor (GIST): optimal timing of resection.
Dudeja V, Armstrong LH, Gupta P, Ansel H, Askari S, Al-Refaie WB
J Gastrointest Surg 2010 Mar;14(3):557-61. Epub 2009 Dec 22 doi: 10.1007/s11605-009-1121-2. PMID: 20033343

Diagnosis

Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM
Cell Cycle 2018;17(6):722-727. doi: 10.1080/15384101.2017.1423223. PMID: 29334307Free PMC Article
Mesenteric fibromatosis after resection for gastrointestinal stromal tumor of stomach: A case report.
Chu Y, Guo Q, Wu D
Medicine (Baltimore) 2017 Dec;96(48):e8792. doi: 10.1097/MD.0000000000008792. PMID: 29310354Free PMC Article
Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor.
Jiang D, He D, Hou Y, Lu W, Shi Y, Hu Q, Lu S, Xu C, Liu Y, Liu J, Tan Y, Zhu X
Diagn Pathol 2013 Jul 31;8:125. doi: 10.1186/1746-1596-8-125. PMID: 23902675Free PMC Article
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
Spontaneous rupture of recurrent gastrointestinal stromal tumor associated with neurofibromatosis type 1.
Wang SM, Chiang RA, Tzen CY, Cheng SP, Liu TP
J Chin Med Assoc 2005 Nov;68(11):538-41. doi: 10.1016/S1726-4901(09)70090-5. PMID: 16323399

Therapy

Disease-free Interval Is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor.
Sutton TL, Walker BS, Billingsley KG, Sheppard BC, Corless CL, Heinrich MC, Mayo SC
Ann Surg Oncol 2021 Nov;28(12):7912-7920. Epub 2021 May 9 doi: 10.1245/s10434-021-10062-6. PMID: 33969462
Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM
Cell Cycle 2018;17(6):722-727. doi: 10.1080/15384101.2017.1423223. PMID: 29334307Free PMC Article
Preoperative imatinib for patients with primary unresectable or metastatic/recurrent gastrointestinal stromal tumor.
Shen C, Chen H, Yin Y, Chen J, Zhang B, Chen Z, Chen J
Clinics (Sao Paulo) 2014 Nov;69(11):758-62. doi: 10.6061/clinics/2014(11)09. PMID: 25518034Free PMC Article
Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor.
Jiang D, He D, Hou Y, Lu W, Shi Y, Hu Q, Lu S, Xu C, Liu Y, Liu J, Tan Y, Zhu X
Diagn Pathol 2013 Jul 31;8:125. doi: 10.1186/1746-1596-8-125. PMID: 23902675Free PMC Article
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article

Prognosis

Disease-free Interval Is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor.
Sutton TL, Walker BS, Billingsley KG, Sheppard BC, Corless CL, Heinrich MC, Mayo SC
Ann Surg Oncol 2021 Nov;28(12):7912-7920. Epub 2021 May 9 doi: 10.1245/s10434-021-10062-6. PMID: 33969462
Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor.
Jiang D, He D, Hou Y, Lu W, Shi Y, Hu Q, Lu S, Xu C, Liu Y, Liu J, Tan Y, Zhu X
Diagn Pathol 2013 Jul 31;8:125. doi: 10.1186/1746-1596-8-125. PMID: 23902675Free PMC Article
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome.
Zhu J, Yang Y, Zhou L, Jiang M, Hou M
BMC Cancer 2010 May 13;10:199. doi: 10.1186/1471-2407-10-199. PMID: 20465813Free PMC Article
Spontaneous rupture of recurrent gastrointestinal stromal tumor associated with neurofibromatosis type 1.
Wang SM, Chiang RA, Tzen CY, Cheng SP, Liu TP
J Chin Med Assoc 2005 Nov;68(11):538-41. doi: 10.1016/S1726-4901(09)70090-5. PMID: 16323399

Clinical prediction guides

Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor.
Jiang D, He D, Hou Y, Lu W, Shi Y, Hu Q, Lu S, Xu C, Liu Y, Liu J, Tan Y, Zhu X
Diagn Pathol 2013 Jul 31;8:125. doi: 10.1186/1746-1596-8-125. PMID: 23902675Free PMC Article
Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350Free PMC Article
A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome.
Zhu J, Yang Y, Zhou L, Jiang M, Hou M
BMC Cancer 2010 May 13;10:199. doi: 10.1186/1471-2407-10-199. PMID: 20465813Free PMC Article

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