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Patent ductus venosus(PDV)

MedGen UID:
91033
Concept ID:
C0344688
Congenital Abnormality; Finding
Synonyms: Congenital portosystemic venous shunt; PDV
SNOMED CT: Patent ductus venosus (253330006)
 
HPO: HP:0012022
Monarch Initiative: MONDO:0011089
OMIM®: 601466

Definition

A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver). [from HPO]

Clinical features

From HPO
Decreased liver function
MedGen UID:
65430
Concept ID:
C0232744
Finding
Reduced ability of the liver to perform its functions.
Hepatic steatosis
MedGen UID:
398225
Concept ID:
C2711227
Disease or Syndrome
Steatosis is a term used to denote lipid accumulation within hepatocytes.
Hepatic encephalopathy
MedGen UID:
5513
Concept ID:
C0019151
Disease or Syndrome
Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes.
Hypergalactosemia
MedGen UID:
892325
Concept ID:
C4023071
Finding
Elevated concentration of galactose in the blood.
Hyperammonemia
MedGen UID:
1802066
Concept ID:
C5574662
Laboratory or Test Result
An increased concentration of ammonia in the blood.
Patent ductus venosus
MedGen UID:
91033
Concept ID:
C0344688
Congenital Abnormality
A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).
Persistent patent ductus venosus
MedGen UID:
868669
Concept ID:
C4023072
Finding
Persistence of blood flow through the ductus venosus for longer than the normal time after birth.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPatent ductus venosus

Conditions with this feature

Patent ductus venosus
MedGen UID:
91033
Concept ID:
C0344688
Congenital Abnormality
A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).

Professional guidelines

PubMed

Napolitano M, Franchi-Abella S, Damasio MB, Augdal TA, Avni FE, Bruno C, Darge K, Ključevšek D, Littooij AS, Lobo L, Mentzel HJ, Riccabona M, Stafrace S, Toso S, Woźniak MM, Di Leo G, Sardanelli F, Ording Müller LS, Petit P
Pediatr Radiol 2021 Feb;51(2):314-331. Epub 2020 Nov 17 doi: 10.1007/s00247-020-04840-9. PMID: 33201318
Chaudry G, Lillis AP, Shaikh R, Padua HM, Chewning RH, Alomari AI
Cardiovasc Intervent Radiol 2018 Jul;41(7):1021-1028. Epub 2018 Mar 6 doi: 10.1007/s00270-018-1924-1. PMID: 29511867
Nishimura Y, Tajima G, Dwi Bahagia A, Sakamoto A, Ono H, Sakura N, Naito K, Hamakawa M, Yoshii C, Kubota M, Kobayashi K, Saheki T
J Inherit Metab Dis 2004;27(1):11-8. doi: 10.1023/B:BOLI.0000016621.29854.d6. PMID: 14970742

Recent clinical studies

Etiology

Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group
Hepatology 2020 Feb;71(2):658-669. Epub 2019 Aug 19 doi: 10.1002/hep.30817. PMID: 31211875
Chaudry G, Lillis AP, Shaikh R, Padua HM, Chewning RH, Alomari AI
Cardiovasc Intervent Radiol 2018 Jul;41(7):1021-1028. Epub 2018 Mar 6 doi: 10.1007/s00270-018-1924-1. PMID: 29511867
Papamichail M, Pizanias M, Heaton N
Eur J Pediatr 2018 Mar;177(3):285-294. Epub 2017 Dec 14 doi: 10.1007/s00431-017-3058-x. PMID: 29243189Free PMC Article
Kamimatsuse A, Onitake Y, Kamei N, Tajima G, Sakura N, Sueda T, Hiyama E
Pediatr Surg Int 2010 Oct;26(10):1025-30. doi: 10.1007/s00383-010-2662-x. PMID: 20661579
Uchino A, Noguchi T, Nomiyama K, Takase Y, Nakazono T, Nojiri J, Kudo S
Neuroradiology 2007 Sep;49(9):715-20. Epub 2007 Jul 12 doi: 10.1007/s00234-007-0243-z. PMID: 17624522

Diagnosis

Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group
Hepatology 2020 Feb;71(2):658-669. Epub 2019 Aug 19 doi: 10.1002/hep.30817. PMID: 31211875
McLin VA, Franchi Abella S, Debray D, Guérin F, Beghetti M, Savale L, Wildhaber BE, Gonzales E; Members of the International Registry of Congenital Porto-Systemic Shunts
J Pediatr Gastroenterol Nutr 2019 May;68(5):615-622. doi: 10.1097/MPG.0000000000002263. PMID: 30628988
Franchi-Abella S, Gonzales E, Ackermann O, Branchereau S, Pariente D, Guérin F; International Registry of Congenital Portosystemic Shunt members
Abdom Radiol (NY) 2018 Aug;43(8):2023-2036. doi: 10.1007/s00261-018-1619-8. PMID: 29730740
Papamichail M, Pizanias M, Heaton N
Eur J Pediatr 2018 Mar;177(3):285-294. Epub 2017 Dec 14 doi: 10.1007/s00431-017-3058-x. PMID: 29243189Free PMC Article
Nagano K, Hoshino H, Nishimura D, Katada N, Sano H, Kato K
J Gastroenterol Hepatol 1999 Mar;14(3):285-8. doi: 10.1046/j.1440-1746.1999.01848.x. PMID: 10197501

Therapy

Brown N, Bhatt H, Salunke A, Chinnakotla S, Qureshi AM, Aggarwal V
Liver Int 2022 Apr;42(4):879-883. Epub 2022 Feb 15 doi: 10.1111/liv.15190. PMID: 35129262
Xiao Y, Li W, Deng X, Chen Z, Peng Y, Wang Y, Zeng Y, Xiao Z
Medicine (Baltimore) 2020 Aug 21;99(34):e21849. doi: 10.1097/MD.0000000000021849. PMID: 32846835Free PMC Article
Lynn AM, Singh S, Congly SE, Khemani D, Johnson DH, Wiesner RH, Kamath PS, Andrews JC, Leise MD
Liver Transpl 2016 Jun;22(6):723-31. doi: 10.1002/lt.24440. PMID: 26970243Free PMC Article
Sharma R, Suddle A, Quaglia A, Peddu P, Karani J, Satyadas T, Heaton N
Hepatobiliary Pancreat Dis Int 2015 Oct;14(5):552-7. doi: 10.1016/s1499-3872(15)60418-0. PMID: 26459734
Nishimura Y, Tajima G, Dwi Bahagia A, Sakamoto A, Ono H, Sakura N, Naito K, Hamakawa M, Yoshii C, Kubota M, Kobayashi K, Saheki T
J Inherit Metab Dis 2004;27(1):11-8. doi: 10.1023/B:BOLI.0000016621.29854.d6. PMID: 14970742

Prognosis

Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group
Hepatology 2020 Feb;71(2):658-669. Epub 2019 Aug 19 doi: 10.1002/hep.30817. PMID: 31211875
Francois B, Gottrand F, Lachaux A, Boyer C, Benoit B, De Smet S
Eur J Pediatr 2017 Dec;176(12):1613-1618. Epub 2017 Sep 14 doi: 10.1007/s00431-017-3013-x. PMID: 28913555
Kamimatsuse A, Onitake Y, Kamei N, Tajima G, Sakura N, Sueda T, Hiyama E
Pediatr Surg Int 2010 Oct;26(10):1025-30. doi: 10.1007/s00383-010-2662-x. PMID: 20661579
Tsai A, Paltiel HJ, Sena LM, Kim HB, Fishman SJ, Alomari AI
Pediatr Radiol 2009 Aug;39(8):823-7. Epub 2009 May 21 doi: 10.1007/s00247-009-1294-6. PMID: 19458947
Yoshimoto Y, Shimizu R, Saeki T, Harada T, Sugio Y, Nomura S, Tanaka H
J Pediatr Surg 2004 Jan;39(1):E1-5. doi: 10.1016/j.jpedsurg.2003.09.035. PMID: 14694396

Clinical prediction guides

Li Y, Deng X, Zhou H, Zheng X, Zhang G, Xiong Q
Eur J Med Res 2023 Feb 11;28(1):74. doi: 10.1186/s40001-023-01039-0. PMID: 36774505Free PMC Article
Traisrisilp K, Sirichotiyakul S, Tongprasert F, Srisupundit K, Luewan S, Jatavan P, Sirilert S, Tongsong T
Taiwan J Obstet Gynecol 2021 Jul;60(4):706-710. doi: 10.1016/j.tjog.2021.05.021. PMID: 34247811
Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group
Hepatology 2020 Feb;71(2):658-669. Epub 2019 Aug 19 doi: 10.1002/hep.30817. PMID: 31211875
Sokollik C, Bandsma RH, Gana JC, van den Heuvel M, Ling SC
J Pediatr Gastroenterol Nutr 2013 Jun;56(6):675-81. doi: 10.1097/MPG.0b013e31828b3750. PMID: 23412540
Nagano K, Hoshino H, Nishimura D, Katada N, Sano H, Kato K
J Gastroenterol Hepatol 1999 Mar;14(3):285-8. doi: 10.1046/j.1440-1746.1999.01848.x. PMID: 10197501

Recent systematic reviews

Napolitano M, Franchi-Abella S, Damasio MB, Augdal TA, Avni FE, Bruno C, Darge K, Ključevšek D, Littooij AS, Lobo L, Mentzel HJ, Riccabona M, Stafrace S, Toso S, Woźniak MM, Di Leo G, Sardanelli F, Ording Müller LS, Petit P
Pediatr Radiol 2021 Feb;51(2):314-331. Epub 2020 Nov 17 doi: 10.1007/s00247-020-04840-9. PMID: 33201318
Matthews TJ, Trochsler MI, Bridgewater FH, Maddern GJ
Br J Surg 2014 Nov;101(12):1509-17. Epub 2014 Sep 9 doi: 10.1002/bjs.9619. PMID: 25200002
Sokollik C, Bandsma RH, Gana JC, van den Heuvel M, Ling SC
J Pediatr Gastroenterol Nutr 2013 Jun;56(6):675-81. doi: 10.1097/MPG.0b013e31828b3750. PMID: 23412540

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