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Abnormal CSF amyloid concentration

MedGen UID:
908313
•Concept ID:
C4280740
•
Finding
Synonyms: Abnormal CSF A[beta]42 level; Abnormal CSF amyloid level
 
HPO: HP:0030860

Definition

Abnormal concentration of amyloid in the cerebrospinal fluid (CSF). [from HPO]

Professional guidelines

PubMed

Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network.
Benson GS, Bauer C, Hausner L, Couturier S, Lewczuk P, Peters O, Hüll M, Jahn H, Jessen F, Pantel J, Teipel SJ, Wagner M, Schuchhardt J, Wiltfang J, Kornhuber J, Frölich L
J Neural Transm (Vienna) 2022 Jun;129(5-6):477-486. Epub 2022 Jan 21 doi: 10.1007/s00702-022-02461-0. PMID: 35061102Free PMC Article
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.
Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article

Recent clinical studies

Etiology

Core CSF Biomarker Profile in Cerebral Amyloid Angiopathy: Updated Meta-Analysis.
Charidimou A, Boulouis G
Neurology 2024 Oct 8;103(7):e209795. Epub 2024 Sep 13 doi: 10.1212/WNL.0000000000209795. PMID: 39270153
Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies.
Bolsewig K, van Unnik AAJM, Blujdea ER, Gonzalez MC, Ashton NJ, Aarsland D, Zetterberg H, Padovani A, Bonanni L, Mollenhauer B, Schade S, Vandenberghe R, Poesen K, Kramberger MG, Paquet C, Bousiges O, Cretin B, Willemse EAJ, Teunissen CE, Lemstra AW; European-Dementia With Lewy Bodies (E-DLB) Consortium
Neurology 2024 Jun 25;102(12):e209418. Epub 2024 Jun 3 doi: 10.1212/WNL.0000000000209418. PMID: 38830138Free PMC Article
Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Effects of certain pre-analytical factors on the performance of plasma phospho-tau217.
Bali D, Hansson O, Janelidze S
Alzheimers Res Ther 2024 Feb 8;16(1):31. doi: 10.1186/s13195-024-01391-1. PMID: 38331843Free PMC Article
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article

Diagnosis

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease.
Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies.
Piazza F, Caminiti SP, Zedde M, Presotto L, DiFrancesco JC, Pascarella R, Giossi A, Sessa M, Poli L, Basso G, Perani D
Neurology 2022 Sep 20;99(12):e1265-e1277. Epub 2022 Aug 8 doi: 10.1212/WNL.0000000000200892. PMID: 35940900Free PMC Article
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article

Therapy

Core CSF Biomarker Profile in Cerebral Amyloid Angiopathy: Updated Meta-Analysis.
Charidimou A, Boulouis G
Neurology 2024 Oct 8;103(7):e209795. Epub 2024 Sep 13 doi: 10.1212/WNL.0000000000209795. PMID: 39270153
Comparison of plasma and CSF biomarkers in predicting cognitive decline.
Aschenbrenner AJ, Li Y, Henson RL, Volluz K, Hassenstab J, Verghese P, West T, Meyer MR, Kirmess KM, Fagan AM, Xiong C, Holtzman D, Morris JC, Bateman RJ, Schindler SE
Ann Clin Transl Neurol 2022 Nov;9(11):1739-1751. Epub 2022 Oct 2 doi: 10.1002/acn3.51670. PMID: 36183195Free PMC Article
Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies.
Piazza F, Caminiti SP, Zedde M, Presotto L, DiFrancesco JC, Pascarella R, Giossi A, Sessa M, Poli L, Basso G, Perani D
Neurology 2022 Sep 20;99(12):e1265-e1277. Epub 2022 Aug 8 doi: 10.1212/WNL.0000000000200892. PMID: 35940900Free PMC Article
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy.
McGeer PL, McGeer EG
Acta Neuropathol 2013 Oct;126(4):479-97. Epub 2013 Sep 20 doi: 10.1007/s00401-013-1177-7. PMID: 24052108

Prognosis

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease.
Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies.
Piazza F, Caminiti SP, Zedde M, Presotto L, DiFrancesco JC, Pascarella R, Giossi A, Sessa M, Poli L, Basso G, Perani D
Neurology 2022 Sep 20;99(12):e1265-e1277. Epub 2022 Aug 8 doi: 10.1212/WNL.0000000000200892. PMID: 35940900Free PMC Article
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article

Clinical prediction guides

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease.
Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M
PLoS Med 2018 Jan;15(1):e1002482. Epub 2018 Jan 25 doi: 10.1371/journal.pmed.1002482. PMID: 29370177Free PMC Article

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