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Elevated CSF amyloid concentration

MedGen UID:
896747
Concept ID:
C4280738
Finding
Synonym: Elevated CSF amyloid level
 
HPO: HP:0030862

Definition

Increased concentration of amyloid in the cerebrospinal fluid (CSF). [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Li G, Shofer JB, Petrie EC, Yu CE, Wilkinson CW, Figlewicz DP, Shutes-David A, Zhang J, Montine TJ, Raskind MA, Quinn JF, Galasko DR, Peskind ER
Alzheimers Res Ther 2017 Jul 3;9(1):48. doi: 10.1186/s13195-017-0271-9. PMID: 28673336Free PMC Article
Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article

Recent clinical studies

Etiology

Wang Q, Schindler SE, Chen G, Mckay NS, McCullough A, Flores S, Liu J, Sun Z, Wang S, Wang W, Hassenstab J, Cruchaga C, Perrin RJ, Fagan AM, Morris JC, Wang Y, Benzinger TLS
Neurology 2024 Feb;102(4):e208013. Epub 2024 Feb 5 doi: 10.1212/WNL.0000000000208013. PMID: 38315956Free PMC Article
Gaur A, Rivet L, Mah E, Bawa KK, Gallagher D, Herrmann N, Lanctôt KL
Ageing Res Rev 2023 Nov;91:102046. Epub 2023 Aug 28 doi: 10.1016/j.arr.2023.102046. PMID: 37647995
Michopoulou S, Prosser A, Kipps C, Dickson J, Guy M, Teeling J
J Alzheimers Dis 2022;89(4):1303-1314. doi: 10.3233/JAD-220523. PMID: 36031900Free PMC Article
Darreh-Shori T, Hosseini SM, Nordberg A
J Alzheimers Dis 2014;39(2):423-40. doi: 10.3233/JAD-130845. PMID: 24217282
Blennow K, De Meyer G, Hansson O, Minthon L, Wallin A, Zetterberg H, Lewczuk P, Vanderstichele H, Vanmechelen E, Kornhuber J, Wiltfang J; KND-Study Group, Heuser I, Maier W, Luckhaus C, Rüther E, Hüll M, Jahn H, Gertz HJ, Frölich L, Hampel H, Pernetzki R
J Nutr Health Aging 2009 Mar;13(3):205-8. doi: 10.1007/s12603-009-0059-0. PMID: 19262954

Diagnosis

Roy S, Kang S, Choi KY, Lee KH, Shin KS, Kang JY
Biosens Bioelectron 2024 Mar 1;247:115898. Epub 2023 Dec 5 doi: 10.1016/j.bios.2023.115898. PMID: 38104391
Gaur A, Rivet L, Mah E, Bawa KK, Gallagher D, Herrmann N, Lanctôt KL
Ageing Res Rev 2023 Nov;91:102046. Epub 2023 Aug 28 doi: 10.1016/j.arr.2023.102046. PMID: 37647995
Gu L, Shu H, Wang Y, Wang P
Curr Alzheimer Res 2023;20(3):149-160. doi: 10.2174/1567205020666230601123123. PMID: 37264656
Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D
J Neurovirol 2019 Oct;25(5):702-709. Epub 2019 Jan 4 doi: 10.1007/s13365-018-0695-4. PMID: 30610738Free PMC Article
Blennow K, De Meyer G, Hansson O, Minthon L, Wallin A, Zetterberg H, Lewczuk P, Vanderstichele H, Vanmechelen E, Kornhuber J, Wiltfang J; KND-Study Group, Heuser I, Maier W, Luckhaus C, Rüther E, Hüll M, Jahn H, Gertz HJ, Frölich L, Hampel H, Pernetzki R
J Nutr Health Aging 2009 Mar;13(3):205-8. doi: 10.1007/s12603-009-0059-0. PMID: 19262954

Therapy

Gaur A, Rivet L, Mah E, Bawa KK, Gallagher D, Herrmann N, Lanctôt KL
Ageing Res Rev 2023 Nov;91:102046. Epub 2023 Aug 28 doi: 10.1016/j.arr.2023.102046. PMID: 37647995
Gu L, Shu H, Wang Y
Neurol Sci 2023 Aug;44(8):2743-2751. Epub 2023 Mar 13 doi: 10.1007/s10072-023-06729-5. PMID: 36913148
Krance SH, Wu CY, Zou Y, Mao H, Toufighi S, He X, Pakosh M, Swardfager W
Mol Psychiatry 2021 Oct;26(10):5532-5541. Epub 2019 Oct 18 doi: 10.1038/s41380-019-0536-8. PMID: 31628417
Li G, Mayer CL, Morelli D, Millard SP, Raskind WH, Petrie EC, Cherrier M, Fagan AM, Raskind MA, Peskind ER
Neurology 2017 Sep 19;89(12):1251-1255. Epub 2017 Aug 18 doi: 10.1212/WNL.0000000000004392. PMID: 28821686Free PMC Article
Schoenfeld HA, West T, Verghese PB, Holubasch M, Shenoy N, Kagan D, Buono C, Zhou W, DeCristofaro M, Douville J, Goodrich GG, Mansfield K, Saravanan C, Cumin F, Webb RL, Bateman RJ
Toxicol Appl Pharmacol 2017 May 15;323:53-65. Epub 2017 Mar 15 doi: 10.1016/j.taap.2017.03.014. PMID: 28315356

Prognosis

Wang Q, Schindler SE, Chen G, Mckay NS, McCullough A, Flores S, Liu J, Sun Z, Wang S, Wang W, Hassenstab J, Cruchaga C, Perrin RJ, Fagan AM, Morris JC, Wang Y, Benzinger TLS
Neurology 2024 Feb;102(4):e208013. Epub 2024 Feb 5 doi: 10.1212/WNL.0000000000208013. PMID: 38315956Free PMC Article
Halbgebauer S, Steinacker P, Riedel D, Oeckl P, Anderl-Straub S, Lombardi J, von Arnim CAF, Nagl M, Giese A, Ludolph AC, Otto M
Alzheimers Res Ther 2022 Nov 22;14(1):175. doi: 10.1186/s13195-022-01122-4. PMID: 36419075Free PMC Article
Michopoulou S, Prosser A, Kipps C, Dickson J, Guy M, Teeling J
J Alzheimers Dis 2022;89(4):1303-1314. doi: 10.3233/JAD-220523. PMID: 36031900Free PMC Article
Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D
J Neurovirol 2019 Oct;25(5):702-709. Epub 2019 Jan 4 doi: 10.1007/s13365-018-0695-4. PMID: 30610738Free PMC Article
Darreh-Shori T, Hosseini SM, Nordberg A
J Alzheimers Dis 2014;39(2):423-40. doi: 10.3233/JAD-130845. PMID: 24217282

Clinical prediction guides

Wang Q, Schindler SE, Chen G, Mckay NS, McCullough A, Flores S, Liu J, Sun Z, Wang S, Wang W, Hassenstab J, Cruchaga C, Perrin RJ, Fagan AM, Morris JC, Wang Y, Benzinger TLS
Neurology 2024 Feb;102(4):e208013. Epub 2024 Feb 5 doi: 10.1212/WNL.0000000000208013. PMID: 38315956Free PMC Article
Michopoulou S, Prosser A, Kipps C, Dickson J, Guy M, Teeling J
J Alzheimers Dis 2022;89(4):1303-1314. doi: 10.3233/JAD-220523. PMID: 36031900Free PMC Article
Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P
Ann Clin Transl Neurol 2021 Jul;8(7):1456-1470. Epub 2021 Jun 15 doi: 10.1002/acn3.51402. PMID: 34129723Free PMC Article
Simoes S, Neufeld JL, Triana-Baltzer G, Moughadam S, Chen EI, Kothiya M, Qureshi YH, Patel V, Honig LS, Kolb H, Small SA
Sci Transl Med 2020 Nov 25;12(571) doi: 10.1126/scitranslmed.aba6334. PMID: 33239387Free PMC Article
Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D
J Neurovirol 2019 Oct;25(5):702-709. Epub 2019 Jan 4 doi: 10.1007/s13365-018-0695-4. PMID: 30610738Free PMC Article

Recent systematic reviews

Gaur A, Rivet L, Mah E, Bawa KK, Gallagher D, Herrmann N, Lanctôt KL
Ageing Res Rev 2023 Nov;91:102046. Epub 2023 Aug 28 doi: 10.1016/j.arr.2023.102046. PMID: 37647995
Krance SH, Wu CY, Zou Y, Mao H, Toufighi S, He X, Pakosh M, Swardfager W
Mol Psychiatry 2021 Oct;26(10):5532-5541. Epub 2019 Oct 18 doi: 10.1038/s41380-019-0536-8. PMID: 31628417

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