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Ovarian Luteinized Thecoma

MedGen UID:
90778
•Concept ID:
C0334399
•
Neoplastic Process
Synonyms: Luteinized Ovarian Thecoma; Luteinized Thecoma of Ovary; Luteinized Thecoma of the Ovary; Thecoma, luteinized
SNOMED CT: Thecoma, luteinized (54482004)

Definition

A variant of ovarian thecoma characterized by the presence of lutein cells. It is associated with a lower frequency of estrogenic manifestations compared to typical thecomas. In a minority of cases androgenic manifestations are present. [from NCI]

Professional guidelines

PubMed

Luteinized thecomatosis and other conditions associated with sclerosing peritonitis: a problem in causation, management, and nomenclature.
Roth LM
Expert Rev Anticancer Ther 2021 Mar;21(3):239-240. Epub 2020 Dec 8 doi: 10.1080/14737140.2021.1853530. PMID: 33290110

Recent clinical studies

Etiology

Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis.
Noyes N, Perretta RC, Fino ME, Matulewicz T, Barakat R
Fertil Steril 2009 Jul;92(1):393.e11-4. Epub 2009 Mar 26 doi: 10.1016/j.fertnstert.2009.01.145. PMID: 19327766

Diagnosis

Luteinized Thecomas ("Thecomatosis") with Sclerosing Peritonitis (LTSP): Report of 2 Cases and Review of an Enigmatic Syndrome Associated with a Peritoneal Proliferation of Specialized (vimentin+/keratin+/CD34+) Submesothelial Fibroblasts.
Altman AD, Bentley JR, Rittenberg PV, Murray SK
J Obstet Gynaecol Can 2016 Jan;38(1):41-50. doi: 10.1016/j.jogc.2015.10.010. PMID: 26872755
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Virilizing luteinized thecoma of the ovary in a 15-year-old female: a case report.
McGee J, Fleming NA, Senterman M, Black AY
J Pediatr Adolesc Gynecol 2009 Oct;22(5):e107-10. Epub 2009 Jul 3 doi: 10.1016/j.jpag.2008.06.002. PMID: 19576809
Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis.
Noyes N, Perretta RC, Fino ME, Matulewicz T, Barakat R
Fertil Steril 2009 Jul;92(1):393.e11-4. Epub 2009 Mar 26 doi: 10.1016/j.fertnstert.2009.01.145. PMID: 19327766
Ossifying luteinized thecoma of the ovary.
Morizane M, Ohara N, Mori T, Murao S
Arch Gynecol Obstet 2003 Jan;267(3):167-9. doi: 10.1007/s00404-001-0282-3. PMID: 12552330

Therapy

Luteinized Thecomas ("Thecomatosis") with Sclerosing Peritonitis (LTSP): Report of 2 Cases and Review of an Enigmatic Syndrome Associated with a Peritoneal Proliferation of Specialized (vimentin+/keratin+/CD34+) Submesothelial Fibroblasts.
Altman AD, Bentley JR, Rittenberg PV, Murray SK
J Obstet Gynaecol Can 2016 Jan;38(1):41-50. doi: 10.1016/j.jogc.2015.10.010. PMID: 26872755
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Sclerosing peritonitis associated with bilateral luteinized thecoma, linked to anticonvulsant therapy.
Levavi H, Sabah G, Heifetz M, Feinmesser M
Eur J Gynaecol Oncol 2009;30(6):695-700. PMID: 20099509
Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis.
Noyes N, Perretta RC, Fino ME, Matulewicz T, Barakat R
Fertil Steril 2009 Jul;92(1):393.e11-4. Epub 2009 Mar 26 doi: 10.1016/j.fertnstert.2009.01.145. PMID: 19327766
Ovarian luteinized thecoma with sclerosing peritonitis in an adult woman treated with leuprolide and toremifene in complete remission at 5 years.
Bianco R, de Rosa G, Staibano S, Somma P, Bianco AR
Gynecol Oncol 2005 Mar;96(3):846-9. doi: 10.1016/j.ygyno.2004.10.044. PMID: 15721435

Clinical prediction guides

Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

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