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Childhood Pineal Parenchymal Tumor of Intermediate Differentiation

MedGen UID:
905698
•Concept ID:
C4086169
•
Neoplastic Process

Definition

A pineal parenchymal tumor of intermediate differentiation that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Pineal Parenchymal Tumor of Intermediate Differentiation

Recent clinical studies

Etiology

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.
Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW
Acta Neuropathol 2020 Feb;139(2):243-257. Epub 2019 Nov 25 doi: 10.1007/s00401-019-02101-0. PMID: 31768671Free PMC Article
Apoptotic proteins and markers of differentiation in childhood pineal parenchymal tumors: relationships and prognostic value.
Marcol W, Mandera M, Grajkowska W, Malinowska-Kołodziej I, Olakowska E, Właszczuk A, Lewin-Kowalik J
Cent Eur Neurosurg 2009 Aug;70(3):115-24. Epub 2009 Aug 21 doi: 10.1055/s-0029-1202356. PMID: 19701869

Diagnosis

Novel pathogenic variant of DICER1 in an adolescent with multinodular goiter, ovarian Sertoli-Leydig cell tumor and pineal parenchymal tumor of intermediate differentiation.
Rivera-Hernández A, Madrigal-González M, Mejía-Carmona L, Martínez-López I, Pérez-Hernández MG, Bernal-Manjarrez J, Luna-Vidal S, Reta-Guerrero S, Rodríguez-Florido MA, Balcázar-Hernández L
J Pediatr Endocrinol Metab 2023 Aug 28;36(8):782-785. Epub 2023 Jun 13 doi: 10.1515/jpem-2023-0149. PMID: 37307239

Prognosis

Apoptotic proteins and markers of differentiation in childhood pineal parenchymal tumors: relationships and prognostic value.
Marcol W, Mandera M, Grajkowska W, Malinowska-Kołodziej I, Olakowska E, Właszczuk A, Lewin-Kowalik J
Cent Eur Neurosurg 2009 Aug;70(3):115-24. Epub 2009 Aug 21 doi: 10.1055/s-0029-1202356. PMID: 19701869

Supplemental Content

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