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Recurrent Acute Myeloid Leukemia, Myelodysplasia-Related

MedGen UID:
902081
•Concept ID:
C4086782
•
Neoplastic Process
Synonyms: Recurrent Acute Myeloid Leukemia with Myelodysplasia-Related Changes; Recurrent HRMDS; Recurrent Myelodysplastic Syndrome; Relapsed or Refractory High-Risk Myelodysplastic Syndrome; Relapsed or Refractory HRMDS

Definition

The reemergence of acute myeloid leukemia, myelodysplasia-related after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Myeloid Leukemia, Myelodysplasia-Related

Professional guidelines

PubMed

The new diagnostic criteria for myelodysplasia-related acute myeloid leukemia is useful for predicting clinical outcome: comparison of the 4th and 5th World Health Organization classifications.
Park HS, Kim HK, Kim HS, Yang Y, Han HS, Lee KH, Son BR, Kwon J
Ann Hematol 2022 Dec;101(12):2645-2654. Epub 2022 Oct 12 doi: 10.1007/s00277-022-05002-7. PMID: 36220882
A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria.
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082
Pediatric acute myeloid leukemia as classified using 2008 WHO criteria: a single-center experience.
Davis KL, Marina N, Arber DA, Ma L, Cherry A, Dahl GV, Heerema-McKenney A
Am J Clin Pathol 2013 Jun;139(6):818-25. doi: 10.1309/AJCP59WKRZVNHETN. PMID: 23690127

Recent clinical studies

Etiology

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.
Stiff A, Fornerod M, Kain BN, Nicolet D, Kelly BJ, Miller KE, Mrózek K, Boateng I, Bollas A, Garfinkle EAR, Momoh O, Fasola FA, Olawumi HO, Mencia-Trinchant N, Kloppers JF, van Marle AC, Hu E, Wijeratne S, Wheeler G, Walker CJ, Buss J, Heyrosa A, Desai H, Laganson A, Hamp E, Abu-Shihab Y, Abaza H, Kronen P, Sen S, Johnstone ME, Quinn K, Wronowski B, Hertlein E, Miles LA, Mims AS, Oakes CC, Blachly JS, Larkin KT, Mundy-Bosse B, Carroll AJ, Powell BL, Kolitz JE, Stone RM, Duarte C, Abbott D, Amaya ML, Jordan CT, Uy GL, Stock W, Archer KJ, Paskett ED, Guzman ML, Levine RL, Menghrajani K, Chakravarty D, Berger MF, Bottomly D, McWeeney SK, Tyner JW, Byrd JC, Salomonis N, Grimes HL, Mardis ER, Eisfeld AK
Nat Genet 2024 Nov;56(11):2434-2446. Epub 2024 Oct 4 doi: 10.1038/s41588-024-01929-x. PMID: 39367245Free PMC Article
The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.
Gurney M, Chekkaf I, Baranwal A, Basmaci R, Katamesh B, Greipp P, Foran JM, Badar T, Mangaonkar AA, Begna KH, Gangat N, Patnaik MM, Litzow MR, Shah MV, Viswanatha DS, He R, Alkhateeb HB, Al-Kali A
Br J Haematol 2023 Jul;202(2):279-283. Epub 2023 May 5 doi: 10.1111/bjh.18850. PMID: 37144345
The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Single-agent and combination biologics in acute myeloid leukemia.
Richard-Carpentier G, DiNardo CD
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):548-556. doi: 10.1182/hematology.2019000059. PMID: 31808888Free PMC Article
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459

Diagnosis

The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
The new diagnostic criteria for myelodysplasia-related acute myeloid leukemia is useful for predicting clinical outcome: comparison of the 4th and 5th World Health Organization classifications.
Park HS, Kim HK, Kim HS, Yang Y, Han HS, Lee KH, Son BR, Kwon J
Ann Hematol 2022 Dec;101(12):2645-2654. Epub 2022 Oct 12 doi: 10.1007/s00277-022-05002-7. PMID: 36220882
Single-agent and combination biologics in acute myeloid leukemia.
Richard-Carpentier G, DiNardo CD
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):548-556. doi: 10.1182/hematology.2019000059. PMID: 31808888Free PMC Article
Reclassification of Acute Myeloid Leukemia According to the 2016 WHO Classification.
Jung J, Cho BS, Kim HJ, Han E, Jang W, Han K, Lee JW, Chung NG, Cho B, Kim M, Kim Y
Ann Lab Med 2019 May;39(3):311-316. doi: 10.3343/alm.2019.39.3.311. PMID: 30623623Free PMC Article
Recent advances in the diagnosis and classification of myeloid neoplasms--comments on the 2008 WHO classification.
Yin CC, Medeiros LJ, Bueso-Ramos CE
Int J Lab Hematol 2010 Oct;32(5):461-76. Epub 2010 Jul 7 doi: 10.1111/j.1751-553X.2010.01246.x. PMID: 20626469Free PMC Article

Therapy

Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
What to use to treat AML: the role of emerging therapies.
Thol F
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):16-23. doi: 10.1182/hematology.2021000309. PMID: 34889359Free PMC Article
Single-agent and combination biologics in acute myeloid leukemia.
Richard-Carpentier G, DiNardo CD
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):548-556. doi: 10.1182/hematology.2019000059. PMID: 31808888Free PMC Article
Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes.
Ikegawa S, Doki N, Kurosawa S, Yamaguchi T, Sakaguchi M, Harada K, Yamamoto K, Hino Y, Shingai N, Senoo Y, Watanabe K, Igarashi A, Najima Y, Kobayashi T, Kakihana K, Sakamaki H, Ohashi K
Leuk Lymphoma 2016;57(1):76-80. doi: 10.3109/10428194.2015.1063148. PMID: 26084204

Prognosis

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.
Stiff A, Fornerod M, Kain BN, Nicolet D, Kelly BJ, Miller KE, Mrózek K, Boateng I, Bollas A, Garfinkle EAR, Momoh O, Fasola FA, Olawumi HO, Mencia-Trinchant N, Kloppers JF, van Marle AC, Hu E, Wijeratne S, Wheeler G, Walker CJ, Buss J, Heyrosa A, Desai H, Laganson A, Hamp E, Abu-Shihab Y, Abaza H, Kronen P, Sen S, Johnstone ME, Quinn K, Wronowski B, Hertlein E, Miles LA, Mims AS, Oakes CC, Blachly JS, Larkin KT, Mundy-Bosse B, Carroll AJ, Powell BL, Kolitz JE, Stone RM, Duarte C, Abbott D, Amaya ML, Jordan CT, Uy GL, Stock W, Archer KJ, Paskett ED, Guzman ML, Levine RL, Menghrajani K, Chakravarty D, Berger MF, Bottomly D, McWeeney SK, Tyner JW, Byrd JC, Salomonis N, Grimes HL, Mardis ER, Eisfeld AK
Nat Genet 2024 Nov;56(11):2434-2446. Epub 2024 Oct 4 doi: 10.1038/s41588-024-01929-x. PMID: 39367245Free PMC Article
The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.
Gurney M, Chekkaf I, Baranwal A, Basmaci R, Katamesh B, Greipp P, Foran JM, Badar T, Mangaonkar AA, Begna KH, Gangat N, Patnaik MM, Litzow MR, Shah MV, Viswanatha DS, He R, Alkhateeb HB, Al-Kali A
Br J Haematol 2023 Jul;202(2):279-283. Epub 2023 May 5 doi: 10.1111/bjh.18850. PMID: 37144345
Single-agent and combination biologics in acute myeloid leukemia.
Richard-Carpentier G, DiNardo CD
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):548-556. doi: 10.1182/hematology.2019000059. PMID: 31808888Free PMC Article
Immunohistochemistry for p53 is a useful tool to identify cases of acute myeloid leukemia with myelodysplasia-related changes that are TP53 mutated, have complex karyotype, and have poor prognosis.
Fernandez-Pol S, Ma L, Ohgami RS, Arber DA
Mod Pathol 2017 Mar;30(3):382-392. Epub 2016 Dec 9 doi: 10.1038/modpathol.2016.206. PMID: 27934876
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459

Clinical prediction guides

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.
Stiff A, Fornerod M, Kain BN, Nicolet D, Kelly BJ, Miller KE, Mrózek K, Boateng I, Bollas A, Garfinkle EAR, Momoh O, Fasola FA, Olawumi HO, Mencia-Trinchant N, Kloppers JF, van Marle AC, Hu E, Wijeratne S, Wheeler G, Walker CJ, Buss J, Heyrosa A, Desai H, Laganson A, Hamp E, Abu-Shihab Y, Abaza H, Kronen P, Sen S, Johnstone ME, Quinn K, Wronowski B, Hertlein E, Miles LA, Mims AS, Oakes CC, Blachly JS, Larkin KT, Mundy-Bosse B, Carroll AJ, Powell BL, Kolitz JE, Stone RM, Duarte C, Abbott D, Amaya ML, Jordan CT, Uy GL, Stock W, Archer KJ, Paskett ED, Guzman ML, Levine RL, Menghrajani K, Chakravarty D, Berger MF, Bottomly D, McWeeney SK, Tyner JW, Byrd JC, Salomonis N, Grimes HL, Mardis ER, Eisfeld AK
Nat Genet 2024 Nov;56(11):2434-2446. Epub 2024 Oct 4 doi: 10.1038/s41588-024-01929-x. PMID: 39367245Free PMC Article
Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
The new diagnostic criteria for myelodysplasia-related acute myeloid leukemia is useful for predicting clinical outcome: comparison of the 4th and 5th World Health Organization classifications.
Park HS, Kim HK, Kim HS, Yang Y, Han HS, Lee KH, Son BR, Kwon J
Ann Hematol 2022 Dec;101(12):2645-2654. Epub 2022 Oct 12 doi: 10.1007/s00277-022-05002-7. PMID: 36220882
A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria.
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082

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