U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal social behavior

MedGen UID:
893112
•Concept ID:
C4021087
•
Finding
Synonym: Abnormal social interactions
 
HPO: HP:0012433

Definition

An abnormality of actions or reactions of a person taking place during interactions with others. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal social behavior

Professional guidelines

PubMed

Practice Parameter for the Assessment and Treatment of Children and Adolescents With Reactive Attachment Disorder and Disinhibited Social Engagement Disorder.
Zeanah CH, Chesher T, Boris NW; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI)
J Am Acad Child Adolesc Psychiatry 2016 Nov;55(11):990-1003. Epub 2016 Aug 25 doi: 10.1016/j.jaac.2016.08.004. PMID: 27806867
Practice parameter for the assessment and treatment of children and adolescents with reactive attachment disorder of infancy and early childhood.
Boris NW, Zeanah CH; Work Group on Quality Issues
J Am Acad Child Adolesc Psychiatry 2005 Nov;44(11):1206-19. doi: 10.1097/01.chi.0000177056.41655.ce. PMID: 16239871

Recent clinical studies

Etiology

Social isolation leads to mild social recognition impairment and losses in brain cellularity.
Guimarães DM, Valério-Gomes B, Vianna-Barbosa RJ, Oliveira W, Neves GÂ, Tovar-Moll F, Lent R
Brain Struct Funct 2023 Dec;228(9):2051-2066. Epub 2023 Sep 10 doi: 10.1007/s00429-023-02705-z. PMID: 37690044
Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice.
Kin K, Francis-Oliveira J, Kano SI, Niwa M
Nat Commun 2023 May 23;14(1):2975. doi: 10.1038/s41467-023-38799-6. PMID: 37221211Free PMC Article
Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia.
Bradley ER, Brustkern J, De Coster L, van den Bos W, McClure SM, Seitz A, Woolley JD
Psychol Med 2020 Mar;50(4):674-682. Epub 2019 Apr 4 doi: 10.1017/S0033291719000552. PMID: 30944045
Functional significance of rare neuroligin 1 variants found in autism.
Nakanishi M, Nomura J, Ji X, Tamada K, Arai T, Takahashi E, Bućan M, Takumi T
PLoS Genet 2017 Aug;13(8):e1006940. Epub 2017 Aug 25 doi: 10.1371/journal.pgen.1006940. PMID: 28841651Free PMC Article
Decision-making in Parkinson's disease patients with and without pathological gambling.
Rossi M, Gerschcovich ER, de Achaval D, Perez-Lloret S, Cerquetti D, Cammarota A, Inés Nouzeilles M, Fahrer R, Merello M, Leiguarda R
Eur J Neurol 2010 Jan;17(1):97-102. Epub 2009 Sep 23 doi: 10.1111/j.1468-1331.2009.02792.x. PMID: 19780806

Diagnosis

Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia.
Bradley ER, Brustkern J, De Coster L, van den Bos W, McClure SM, Seitz A, Woolley JD
Psychol Med 2020 Mar;50(4):674-682. Epub 2019 Apr 4 doi: 10.1017/S0033291719000552. PMID: 30944045
Practice Parameter for the Assessment and Treatment of Children and Adolescents With Reactive Attachment Disorder and Disinhibited Social Engagement Disorder.
Zeanah CH, Chesher T, Boris NW; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI)
J Am Acad Child Adolesc Psychiatry 2016 Nov;55(11):990-1003. Epub 2016 Aug 25 doi: 10.1016/j.jaac.2016.08.004. PMID: 27806867
Implicit Social Biases in People With Autism.
Birmingham E, Stanley D, Nair R, Adolphs R
Psychol Sci 2015 Nov;26(11):1693-705. Epub 2015 Sep 18 doi: 10.1177/0956797615595607. PMID: 26386014Free PMC Article
Autism and epistemology IV: Does autism need a theory of mind?
Fisch GS
Am J Med Genet A 2013 Oct;161A(10):2464-80. Epub 2013 Aug 16 doi: 10.1002/ajmg.a.36135. PMID: 23956150
Decision-making in Parkinson's disease patients with and without pathological gambling.
Rossi M, Gerschcovich ER, de Achaval D, Perez-Lloret S, Cerquetti D, Cammarota A, Inés Nouzeilles M, Fahrer R, Merello M, Leiguarda R
Eur J Neurol 2010 Jan;17(1):97-102. Epub 2009 Sep 23 doi: 10.1111/j.1468-1331.2009.02792.x. PMID: 19780806

Therapy

Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia.
Bradley ER, Brustkern J, De Coster L, van den Bos W, McClure SM, Seitz A, Woolley JD
Psychol Med 2020 Mar;50(4):674-682. Epub 2019 Apr 4 doi: 10.1017/S0033291719000552. PMID: 30944045
Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice.
Xing X, Zhang J, Wu K, Cao B, Li X, Jiang F, Hu Z, Xia K, Li JD
Sci Rep 2019 Feb 28;9(1):3041. doi: 10.1038/s41598-019-39434-5. PMID: 30816216Free PMC Article
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.
Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH
Sci Transl Med 2015 Jan 21;7(271):271ra8. doi: 10.1126/scitranslmed.3010257. PMID: 25609168Free PMC Article
Decision-making in Parkinson's disease patients with and without pathological gambling.
Rossi M, Gerschcovich ER, de Achaval D, Perez-Lloret S, Cerquetti D, Cammarota A, Inés Nouzeilles M, Fahrer R, Merello M, Leiguarda R
Eur J Neurol 2010 Jan;17(1):97-102. Epub 2009 Sep 23 doi: 10.1111/j.1468-1331.2009.02792.x. PMID: 19780806
Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best?
Brüne M, Abdel-Hamid M, Lehmkämper C, Sonntag C
Schizophr Res 2007 May;92(1-3):151-9. Epub 2007 Mar 7 doi: 10.1016/j.schres.2007.01.006. PMID: 17346931

Prognosis

Individual differences in social behavior predict amygdala response to fearful facial expressions in Williams syndrome.
Haas BW, Hoeft F, Searcy YM, Mills D, Bellugi U, Reiss A
Neuropsychologia 2010 Apr;48(5):1283-8. Epub 2009 Dec 28 doi: 10.1016/j.neuropsychologia.2009.12.030. PMID: 20036269Free PMC Article
Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best?
Brüne M, Abdel-Hamid M, Lehmkämper C, Sonntag C
Schizophr Res 2007 May;92(1-3):151-9. Epub 2007 Mar 7 doi: 10.1016/j.schres.2007.01.006. PMID: 17346931
Practice parameter for the assessment and treatment of children and adolescents with reactive attachment disorder of infancy and early childhood.
Boris NW, Zeanah CH; Work Group on Quality Issues
J Am Acad Child Adolesc Psychiatry 2005 Nov;44(11):1206-19. doi: 10.1097/01.chi.0000177056.41655.ce. PMID: 16239871

Clinical prediction guides

Social isolation leads to mild social recognition impairment and losses in brain cellularity.
Guimarães DM, Valério-Gomes B, Vianna-Barbosa RJ, Oliveira W, Neves GÂ, Tovar-Moll F, Lent R
Brain Struct Funct 2023 Dec;228(9):2051-2066. Epub 2023 Sep 10 doi: 10.1007/s00429-023-02705-z. PMID: 37690044
Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice.
Kin K, Francis-Oliveira J, Kano SI, Niwa M
Nat Commun 2023 May 23;14(1):2975. doi: 10.1038/s41467-023-38799-6. PMID: 37221211Free PMC Article
Implicit Social Biases in People With Autism.
Birmingham E, Stanley D, Nair R, Adolphs R
Psychol Sci 2015 Nov;26(11):1693-705. Epub 2015 Sep 18 doi: 10.1177/0956797615595607. PMID: 26386014Free PMC Article
Autism and epistemology IV: Does autism need a theory of mind?
Fisch GS
Am J Med Genet A 2013 Oct;161A(10):2464-80. Epub 2013 Aug 16 doi: 10.1002/ajmg.a.36135. PMID: 23956150
Decision-making in Parkinson's disease patients with and without pathological gambling.
Rossi M, Gerschcovich ER, de Achaval D, Perez-Lloret S, Cerquetti D, Cammarota A, Inés Nouzeilles M, Fahrer R, Merello M, Leiguarda R
Eur J Neurol 2010 Jan;17(1):97-102. Epub 2009 Sep 23 doi: 10.1111/j.1468-1331.2009.02792.x. PMID: 19780806

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...