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Abnormal behavior

MedGen UID:
535345
•Concept ID:
C0233514
•
Finding
Synonyms: Behavioral abnormalities; Behavioral abnormality; Behavioral/psychiatric abnormalities
SNOMED CT: Abnormal behavior (25786006); Strange behavior (25786006); Abnormal conduct (25786006); Disturbance of conation (25786006)

Definition

Conduct that is unusual for the individual. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal behavior

Professional guidelines

PubMed

Genotype-Phenotype Correlations in 2q37-Deletion Syndrome: An Update of the Clinical Spectrum and Literature Review.
Gavril EC, Nucă I, Pânzaru MC, Ivanov AV, Mihai CT, Antoci LM, Ciobanu CG, Rusu C, Popescu R
Genes (Basel) 2023 Feb 11;14(2) doi: 10.3390/genes14020465. PMID: 36833393Free PMC Article
Binge-Eating Disorder and Comorbid Conditions: Differential Diagnosis and Implications for Treatment.
Citrome L
J Clin Psychiatry 2017;78 Suppl 1:9-13. doi: 10.4088/JCP.sh16003su1c.02. PMID: 28125173
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829

Recent clinical studies

Etiology

Maternal Nutrition and Neurodevelopment: A Scoping Review.
Cortés-Albornoz MC, García-Guáqueta DP, Velez-van-Meerbeke A, Talero-Gutiérrez C
Nutrients 2021 Oct 8;13(10) doi: 10.3390/nu13103530. PMID: 34684531Free PMC Article
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group
Neurology 2018 Apr 3;90(14):e1204-e1211. Epub 2018 Mar 14 doi: 10.1212/WNL.0000000000005254. PMID: 29540584Free PMC Article
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Effects of vitamin B12 and folate deficiency on brain development in children.
Black MM
Food Nutr Bull 2008 Jun;29(2 Suppl):S126-31. doi: 10.1177/15648265080292S117. PMID: 18709887Free PMC Article

Diagnosis

Genotype-Phenotype Correlations in 2q37-Deletion Syndrome: An Update of the Clinical Spectrum and Literature Review.
Gavril EC, Nucă I, Pânzaru MC, Ivanov AV, Mihai CT, Antoci LM, Ciobanu CG, Rusu C, Popescu R
Genes (Basel) 2023 Feb 11;14(2) doi: 10.3390/genes14020465. PMID: 36833393Free PMC Article
De novo variants in ATP2B1 lead to neurodevelopmental delay.
Rahimi MJ, Urban N, Wegler M, Sticht H, Schaefer M, Popp B, Gaunitz F, Morleo M, Nigro V, Maitz S, Mancini GMS, Ruivenkamp C, Suk EK, Bartolomaeus T, Merkenschlager A, Koboldt D, Bartholomew D, Stegmann APA, Sinnema M, Duynisveld I, Salvarinova R, Race S, de Vries BBA, Trimouille A, Naudion S, Marom D, Hamiel U, Henig N, Demurger F, Rahner N, Bartels E, Hamm JA, Putnam AM, Person R, Abou Jamra R, Oppermann H
Am J Hum Genet 2022 May 5;109(5):944-952. Epub 2022 Mar 30 doi: 10.1016/j.ajhg.2022.03.009. PMID: 35358416Free PMC Article
Anti-Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Encephalitis: A Review.
Zhang TY, Cai MT, Zheng Y, Lai QL, Shen CH, Qiao S, Zhang YX
Front Immunol 2021;12:652820. Epub 2021 May 21 doi: 10.3389/fimmu.2021.652820. PMID: 34093540Free PMC Article
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
The plastic human brain cortex.
Pascual-Leone A, Amedi A, Fregni F, Merabet LB
Annu Rev Neurosci 2005;28:377-401. doi: 10.1146/annurev.neuro.27.070203.144216. PMID: 16022601

Therapy

Maternal Nutrition and Neurodevelopment: A Scoping Review.
Cortés-Albornoz MC, García-Guáqueta DP, Velez-van-Meerbeke A, Talero-Gutiérrez C
Nutrients 2021 Oct 8;13(10) doi: 10.3390/nu13103530. PMID: 34684531Free PMC Article
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group
Neurology 2018 Apr 3;90(14):e1204-e1211. Epub 2018 Mar 14 doi: 10.1212/WNL.0000000000005254. PMID: 29540584Free PMC Article
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW
Proc Natl Acad Sci U S A 2014 Oct 28;111(43):15550-5. Epub 2014 Oct 13 doi: 10.1073/pnas.1416940111. PMID: 25313065Free PMC Article
Effects of vitamin B12 and folate deficiency on brain development in children.
Black MM
Food Nutr Bull 2008 Jun;29(2 Suppl):S126-31. doi: 10.1177/15648265080292S117. PMID: 18709887Free PMC Article

Prognosis

Anti-Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Encephalitis: A Review.
Zhang TY, Cai MT, Zheng Y, Lai QL, Shen CH, Qiao S, Zhang YX
Front Immunol 2021;12:652820. Epub 2021 May 21 doi: 10.3389/fimmu.2021.652820. PMID: 34093540Free PMC Article
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group
Neurology 2018 Apr 3;90(14):e1204-e1211. Epub 2018 Mar 14 doi: 10.1212/WNL.0000000000005254. PMID: 29540584Free PMC Article
Kleine-Levin syndrome; An update and mini-review.
Gadoth N, Oksenberg A
Brain Dev 2017 Sep;39(8):665-671. Epub 2017 Apr 20 doi: 10.1016/j.braindev.2017.04.003. PMID: 28434769
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829

Clinical prediction guides

Genotype-Phenotype Correlations in 2q37-Deletion Syndrome: An Update of the Clinical Spectrum and Literature Review.
Gavril EC, Nucă I, Pânzaru MC, Ivanov AV, Mihai CT, Antoci LM, Ciobanu CG, Rusu C, Popescu R
Genes (Basel) 2023 Feb 11;14(2) doi: 10.3390/genes14020465. PMID: 36833393Free PMC Article
De novo variants in ATP2B1 lead to neurodevelopmental delay.
Rahimi MJ, Urban N, Wegler M, Sticht H, Schaefer M, Popp B, Gaunitz F, Morleo M, Nigro V, Maitz S, Mancini GMS, Ruivenkamp C, Suk EK, Bartolomaeus T, Merkenschlager A, Koboldt D, Bartholomew D, Stegmann APA, Sinnema M, Duynisveld I, Salvarinova R, Race S, de Vries BBA, Trimouille A, Naudion S, Marom D, Hamiel U, Henig N, Demurger F, Rahner N, Bartels E, Hamm JA, Putnam AM, Person R, Abou Jamra R, Oppermann H
Am J Hum Genet 2022 May 5;109(5):944-952. Epub 2022 Mar 30 doi: 10.1016/j.ajhg.2022.03.009. PMID: 35358416Free PMC Article
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836
Autism Spectrum Disorders - Diagnosis and Management.
Mukherjee SB
Indian J Pediatr 2017 Apr;84(4):307-314. Epub 2017 Jan 19 doi: 10.1007/s12098-016-2272-2. PMID: 28101829
Sulforaphane treatment of autism spectrum disorder (ASD).
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW
Proc Natl Acad Sci U S A 2014 Oct 28;111(43):15550-5. Epub 2014 Oct 13 doi: 10.1073/pnas.1416940111. PMID: 25313065Free PMC Article

Recent systematic reviews

Cerebral oxygenation during cardiopulmonary exercise testing in cardiorespiratory diseases: A systematic review.
Galdino GAM, Rehder-Santos P, Linares SN, Beltrame T, Catai AM
Heart Lung 2023 May-Jun;59:23-32. Epub 2023 Jan 19 doi: 10.1016/j.hrtlng.2023.01.004. PMID: 36669443
Psychological Impact of Pro-Anorexia and Pro-Eating Disorder Websites on Adolescent Females: A Systematic Review.
Mento C, Silvestri MC, Muscatello MRA, Rizzo A, Celebre L, Praticò M, Zoccali RA, Bruno A
Int J Environ Res Public Health 2021 Feb 23;18(4) doi: 10.3390/ijerph18042186. PMID: 33672305Free PMC Article
Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration.
Heller J, Brcina N, Dogan I, Holtbernd F, Romanzetti S, Schulz JB, Schiefer J, Reetz K
Sleep Med Rev 2017 Aug;34:23-33. Epub 2016 Jun 25 doi: 10.1016/j.smrv.2016.06.006. PMID: 27542516
Pharmacological treatment for Kleine-Levin syndrome.
Oliveira MM, Conti C, Prado GF
Cochrane Database Syst Rev 2013 Aug 14;(8):CD006685. doi: 10.1002/14651858.CD006685.pub3. PMID: 23945927
Pharmacological treatment for Kleine-Levin Syndrome.
Oliveira MM, Conti C, Saconato H, Fernandes do Prado G
Cochrane Database Syst Rev 2009 Apr 15;(2):CD006685. doi: 10.1002/14651858.CD006685.pub2. PMID: 19370648

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