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Sporadic Gastric Diffuse Adenocarcinoma

MedGen UID:
328047
•Concept ID:
C1710165
•
Neoplastic Process
Synonym: Sporadic Diffuse Gastric Adenocarcinoma

Definition

A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSporadic Gastric Diffuse Adenocarcinoma

Professional guidelines

PubMed

CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype.
Corso G, Marino E, Zanzottera C, Oliveira C, Bernard L, Macis D, Figueiredo J, Pereira J, Carneiro P, Massari G, Barberis M, De Scalzi AM, Taormina SV, Sajjadi E, Sangalli C, Gandini S, D'Ecclesiis O, Trovato CM, Rotili A, Pesapane F, Nicosia L, La Vecchia C, Galimberti V, Guerini-Rocco E, Bonanni B, Veronesi P
JAMA Netw Open 2024 Apr 1;7(4):e247862. doi: 10.1001/jamanetworkopen.2024.7862. PMID: 38652475Free PMC Article
SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors.
Norton JA, Kim T, Kim J, McCarter MD, Kelly KJ, Wong J, Sicklick JK
J Gastrointest Surg 2018 Jan;22(1):32-42. Epub 2017 Aug 14 doi: 10.1007/s11605-017-3533-8. PMID: 28808875Free PMC Article
Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma.
Inaba K, Kushima R, Murakami N, Kuroda Y, Harada K, Kitaguchi M, Yoshio K, Sekii S, Takahashi K, Morota M, Mayahara H, Ito Y, Sumi M, Uno T, Itami J
BMC Cancer 2013 Oct 26;13:499. doi: 10.1186/1471-2407-13-499. PMID: 24159918Free PMC Article

Recent clinical studies

Therapy

Gastric cancer: new genetic developments.
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459
'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential.
Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M
J Pathol 1999 Apr;187(5):511-7. doi: 10.1002/(SICI)1096-9896(199904)187:5<511::AID-PATH308>3.0.CO;2-8. PMID: 10398114

Prognosis

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma.
Inaba K, Kushima R, Murakami N, Kuroda Y, Harada K, Kitaguchi M, Yoshio K, Sekii S, Takahashi K, Morota M, Mayahara H, Ito Y, Sumi M, Uno T, Itami J
BMC Cancer 2013 Oct 26;13:499. doi: 10.1186/1471-2407-13-499. PMID: 24159918Free PMC Article
Microsatellite instability in solitary and sporadic gastric cancer.
Perez RO, Jacob CE, D'Ottaviano FL, Alvarenga C, Ribeiro AS, Ribeiro U Jr, Bresciani CJ, Zilberstein B, Krieger JE, Habr-Gama A, Gama-Rodrigues JJ
Rev Hosp Clin Fac Med Sao Paulo 2004 Oct;59(5):279-85. Epub 2004 Oct 29 doi: 10.1590/s0041-87812004000500010. PMID: 15543400
Molecular biology of gastric cancer.
El-Rifai W, Powell SM
Semin Radiat Oncol 2002 Apr;12(2):128-40. doi: 10.1053/srao.2002.30815. PMID: 11979414

Clinical prediction guides

Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori-naïve patients.
Shibagaki K, Mishiro T, Fukuyama C, Takahashi Y, Itawaki A, Nonomura S, Yamashita N, Kotani S, Mikami H, Izumi D, Kawashima K, Ishimura N, Nagase M, Araki A, Ishikawa N, Maruyama R, Kushima R, Ishihara S
Virchows Arch 2021 Oct;479(4):687-695. Epub 2021 May 27 doi: 10.1007/s00428-021-03124-3. PMID: 34043063
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma.
Inaba K, Kushima R, Murakami N, Kuroda Y, Harada K, Kitaguchi M, Yoshio K, Sekii S, Takahashi K, Morota M, Mayahara H, Ito Y, Sumi M, Uno T, Itami J
BMC Cancer 2013 Oct 26;13:499. doi: 10.1186/1471-2407-13-499. PMID: 24159918Free PMC Article
Gastric cancer carcinogenesis and tumor progression.
Corso G, Seruca R, Roviello F
Ann Ital Chir 2012 May-Jun;83(3):172-6. PMID: 22595727
Molecular biology of gastric cancer.
El-Rifai W, Powell SM
Semin Radiat Oncol 2002 Apr;12(2):128-40. doi: 10.1053/srao.2002.30815. PMID: 11979414

Recent systematic reviews

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article

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