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Abnormal aortic morphology

MedGen UID:
871269
•Concept ID:
C4025756
•
Anatomical Abnormality
Synonyms: Abnormal aorta morphology; Abnormality of the aorta
 
HPO: HP:0001679

Definition

An abnormality of the aorta. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal aortic morphology

Professional guidelines

PubMed

Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review.
Gaudino M, Di Franco A, Arbustini E, Bacha E, Bates ER, Cameron DE, Cao D, David TE, De Paulis R, El-Hamamsy I, Farooqi KM, Girardi LN, Gräni C, Kochav JD, Molossi S, Puskas JD, Rao SV, Sandner S, Tatoulis J, Truong QA, Weinsaft JW, Zimpfer D, Mery CM
J Am Coll Cardiol 2023 Nov 21;82(21):2034-2053. Epub 2023 Oct 16 doi: 10.1016/j.jacc.2023.08.012. PMID: 37855757
Calcific aortic valve disease: mechanisms, prevention and treatment.
Moncla LM, Briend M, Bossé Y, Mathieu P
Nat Rev Cardiol 2023 Aug;20(8):546-559. Epub 2023 Feb 24 doi: 10.1038/s41569-023-00845-7. PMID: 36829083
Health Care Supervision for Children With Williams Syndrome.
Morris CA, Braddock SR; COUNCIL ON GENETICS
Pediatrics 2020 Feb;145(2) Epub 2020 Jan 21 doi: 10.1542/peds.2019-3761. PMID: 31964759

Recent clinical studies

Etiology

Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review.
Gaudino M, Di Franco A, Arbustini E, Bacha E, Bates ER, Cameron DE, Cao D, David TE, De Paulis R, El-Hamamsy I, Farooqi KM, Girardi LN, Gräni C, Kochav JD, Molossi S, Puskas JD, Rao SV, Sandner S, Tatoulis J, Truong QA, Weinsaft JW, Zimpfer D, Mery CM
J Am Coll Cardiol 2023 Nov 21;82(21):2034-2053. Epub 2023 Oct 16 doi: 10.1016/j.jacc.2023.08.012. PMID: 37855757
Anomalous Coronary Arteries: A State-of-the-Art Approach.
Molossi S, Doan T, Sachdeva S
Cardiol Clin 2023 Feb;41(1):51-69. doi: 10.1016/j.ccl.2022.08.005. PMID: 36368811
Circumflex aorta: An uncharted territory.
Haranal M, Srimurugan B, Sivalingam S
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):217-225. Epub 2021 May 6 doi: 10.1177/02184923211015092. PMID: 33957784
Aortopathy in Congenital Heart Disease.
Cotts TB, Salciccioli KB, Swanson SK, Yetman AT
Cardiol Clin 2020 Aug;38(3):325-336. Epub 2020 Jun 3 doi: 10.1016/j.ccl.2020.04.002. PMID: 32622488
Congenital vascular ring.
Yoshimura N, Fukahara K, Yamashita A, Doi T, Yamashita S, Homma T, Yokoyama S, Aoki M, Higashida A, Shimada Y, Toritsuka D, Nagao K, Ikeno Y
Surg Today 2020 Oct;50(10):1151-1158. Epub 2019 Nov 1 doi: 10.1007/s00595-019-01907-5. PMID: 31676999

Diagnosis

Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review.
Gaudino M, Di Franco A, Arbustini E, Bacha E, Bates ER, Cameron DE, Cao D, David TE, De Paulis R, El-Hamamsy I, Farooqi KM, Girardi LN, Gräni C, Kochav JD, Molossi S, Puskas JD, Rao SV, Sandner S, Tatoulis J, Truong QA, Weinsaft JW, Zimpfer D, Mery CM
J Am Coll Cardiol 2023 Nov 21;82(21):2034-2053. Epub 2023 Oct 16 doi: 10.1016/j.jacc.2023.08.012. PMID: 37855757
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Aortopathy in Congenital Heart Disease.
Cotts TB, Salciccioli KB, Swanson SK, Yetman AT
Cardiol Clin 2020 Aug;38(3):325-336. Epub 2020 Jun 3 doi: 10.1016/j.ccl.2020.04.002. PMID: 32622488
Congenital vascular ring.
Yoshimura N, Fukahara K, Yamashita A, Doi T, Yamashita S, Homma T, Yokoyama S, Aoki M, Higashida A, Shimada Y, Toritsuka D, Nagao K, Ikeno Y
Surg Today 2020 Oct;50(10):1151-1158. Epub 2019 Nov 1 doi: 10.1007/s00595-019-01907-5. PMID: 31676999
Congenital Variants and Anomalies of the Aortic Arch.
Hanneman K, Newman B, Chan F
Radiographics 2017 Jan-Feb;37(1):32-51. Epub 2016 Nov 18 doi: 10.1148/rg.2017160033. PMID: 27860551

Therapy

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
de la Fuente-Alonso A, Toral M, Alfayate A, Ruiz-Rodríguez MJ, Bonzón-Kulichenko E, Teixido-Tura G, Martínez-Martínez S, Méndez-Olivares MJ, López-Maderuelo D, González-Valdés I, Garcia-Izquierdo E, Mingo S, Martín CE, Muiño-Mosquera L, De Backer J, Nistal JF, Forteza A, Evangelista A, Vázquez J, Campanero MR, Redondo JM
Nat Commun 2021 May 11;12(1):2628. doi: 10.1038/s41467-021-22933-3. PMID: 33976159Free PMC Article
Editor's Choice - Management of Descending Thoracic Aorta Diseases: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS).
Riambau V, Böckler D, Brunkwall J, Cao P, Chiesa R, Coppi G, Czerny M, Fraedrich G, Haulon S, Jacobs MJ, Lachat ML, Moll FL, Setacci C, Taylor PR, Thompson M, Trimarchi S, Verhagen HJ, Verhoeven EL, Esvs Guidelines Committee, Kolh P, de Borst GJ, Chakfé N, Debus ES, Hinchliffe RJ, Kakkos S, Koncar I, Lindholt JS, Vega de Ceniga M, Vermassen F, Verzini F, Document Reviewers, Kolh P, Black JH 3rd, Busund R, Björck M, Dake M, Dick F, Eggebrecht H, Evangelista A, Grabenwöger M, Milner R, Naylor AR, Ricco JB, Rousseau H, Schmidli J
Eur J Vasc Endovasc Surg 2017 Jan;53(1):4-52. doi: 10.1016/j.ejvs.2016.06.005. PMID: 28081802
Aortic Wall Injury Related to Endovascular Therapy for Aortic Coarctation.
Tretter JT, Jones TK, McElhinney DB
Circ Cardiovasc Interv 2015 Sep;8(9):e002840. doi: 10.1161/CIRCINTERVENTIONS.115.002840. PMID: 26291468
Post-stenotic aortic dilatation.
Wilton E, Jahangiri M
J Cardiothorac Surg 2006 Mar 3;1:7. doi: 10.1186/1749-8090-1-7. PMID: 16722611Free PMC Article
The "skinny aorta".
Israel G, Krinsky G, Lee V
Clin Imaging 2002 Mar-Apr;26(2):116-21. doi: 10.1016/s0899-7071(01)00368-0. PMID: 11852219

Prognosis

Computed tomography in tetralogy of Fallot: pre- and postoperative imaging evaluation.
Zucker EJ
Pediatr Radiol 2022 Dec;52(13):2485-2497. Epub 2021 Aug 24 doi: 10.1007/s00247-021-05179-5. PMID: 34427695
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Congenital Variants and Anomalies of the Aortic Arch.
Hanneman K, Newman B, Chan F
Radiographics 2017 Jan-Feb;37(1):32-51. Epub 2016 Nov 18 doi: 10.1148/rg.2017160033. PMID: 27860551
Imaging of congenital anomalies of the coronary arteries.
Raimondi F, Bonnet D
Diagn Interv Imaging 2016 May;97(5):561-9. Epub 2016 Apr 26 doi: 10.1016/j.diii.2016.03.009. PMID: 27132711
Coarctation as a deformation.
Rosenberg HS
Pediatr Pathol 1990;10(1-2):103-15. doi: 10.3109/15513819009067100. PMID: 2179916

Clinical prediction guides

Histologic and morphologic character of pediatric abdominal aortic developmental coarctation and hypoplasia.
Heider A, Gordon D, Coleman DM, Eliason JL, Ganesh SK, Stanley JC
J Vasc Surg 2022 Aug;76(2):556-563.e4. Epub 2022 Feb 9 doi: 10.1016/j.jvs.2022.01.121. PMID: 35149163
International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
J Thorac Cardiovasc Surg 2021 Sep;162(3):e383-e414. Epub 2021 Jul 22 doi: 10.1016/j.jtcvs.2021.06.019. PMID: 34304896
Aortic valve-related aortopathy: assessing optimal timing of surgical intervention.
Petersen J, Sequeira-Gross T, Naito S, Reichenspurner H, Girdauskas E
Expert Rev Cardiovasc Ther 2019 Oct;17(10):753-761. Epub 2019 Oct 14 doi: 10.1080/14779072.2019.1675511. PMID: 31591904
MicroRNAs fingerprint of bicuspid aortic valve.
Sabatino J, Wicik Z, De Rosa S, Eyileten C, Jakubik D, Spaccarotella C, Mongiardo A, Postula M, Indolfi C
J Mol Cell Cardiol 2019 Sep;134:98-106. Epub 2019 Jul 3 doi: 10.1016/j.yjmcc.2019.07.001. PMID: 31278905
Aorto-ventricular tunnel.
McKay R
Orphanet J Rare Dis 2007 Oct 8;2:41. doi: 10.1186/1750-1172-2-41. PMID: 17922908Free PMC Article

Recent systematic reviews

Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review.
Gaudino M, Di Franco A, Arbustini E, Bacha E, Bates ER, Cameron DE, Cao D, David TE, De Paulis R, El-Hamamsy I, Farooqi KM, Girardi LN, Gräni C, Kochav JD, Molossi S, Puskas JD, Rao SV, Sandner S, Tatoulis J, Truong QA, Weinsaft JW, Zimpfer D, Mery CM
J Am Coll Cardiol 2023 Nov 21;82(21):2034-2053. Epub 2023 Oct 16 doi: 10.1016/j.jacc.2023.08.012. PMID: 37855757
Bicuspid aortic valve morphology and its impact on aortic diameters-A systematic review with meta-analysis and meta-regression.
Miśkowiec D, Lipiec P, Szymczyk E, Wejner-Mik P, Michalski B, Kupczyńska K, Wierzbowska-Drabik K, Kasprzak JD
Echocardiography 2018 May;35(5):667-677. Epub 2018 Feb 4 doi: 10.1111/echo.13818. PMID: 29399873
Posterior nutcracker syndrome - a systematic review.
Park JH, Lee GH, Lee SM, Eisenhut M, Kronbichler A, Lee KH, Shin JI
Vasa 2018 Jan;47(1):23-29. Epub 2017 Nov 22 doi: 10.1024/0301-1526/a000670. PMID: 29165061
A systematic review and meta-analysis of variations in branching patterns of the adult aortic arch.
Popieluszko P, Henry BM, Sanna B, Hsieh WC, Saganiak K, Pękala PA, Walocha JA, Tomaszewski KA
J Vasc Surg 2018 Jul;68(1):298-306.e10. Epub 2017 Aug 31 doi: 10.1016/j.jvs.2017.06.097. PMID: 28865978
Balloon Dilatation and Stenting for Aortic Coarctation: A Systematic Review and Meta-Analysis.
Salcher M, Naci H, Law TJ, Kuehne T, Schubert S, Kelm M; Cardioproof Consortium
Circ Cardiovasc Interv 2016 Jun;9(6) doi: 10.1161/CIRCINTERVENTIONS.115.003153. PMID: 27296199

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