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Aortic smooth muscle cell disorganization

MedGen UID:
1694670
•Concept ID:
C5139122
•
Pathologic Function
Synonym: Aortic smooth muscle cell disorganisation
 
HPO: HP:0032088

Definition

Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAortic smooth muscle cell disorganization

Recent clinical studies

Etiology

Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea.
Yang YY, Yu HH, Jiao XL, Li LY, Du YH, Li J, Lv QW, Zhang HN, Zhang J, Hu CW, Zhang XP, Wei YX, Qin YW
Biochem Pharmacol 2021 Apr;186:114502. Epub 2021 Mar 6 doi: 10.1016/j.bcp.2021.114502. PMID: 33684391
Histologic Abnormalities of the Ascending Aorta: Effects on Aortic Remodeling after Intracardiac Repair of Tetralogy of Fallot.
Chowdhury UK, Sankhyan LK, Avneesh S, Ray R, Kalaivani M, Hasija S, Chauhan A
Tex Heart Inst J 2020 Apr 1;47(2):86-95. doi: 10.14503/THIJ-17-6279. PMID: 32603461Free PMC Article
Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.
Fabian O, Gebauer R, Koblizek M, Hornofova L, Janousek J
Cardiovasc Pathol 2019 May-Jun;40:59-64. Epub 2019 Feb 28 doi: 10.1016/j.carpath.2019.02.004. PMID: 30904751
Pathogenesis of aortic wall complications in Marfan syndrome.
Grewal N, Gittenberger-de Groot AC
Cardiovasc Pathol 2018 Mar-Apr;33:62-69. Epub 2018 Feb 2 doi: 10.1016/j.carpath.2018.01.005. PMID: 29433109
Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm.
Lee J, Shen M, Parajuli N, Oudit GY, McMurtry MS, Kassiri Z
J Mol Med (Berl) 2014 Sep;92(9):939-49. Epub 2014 Jun 5 doi: 10.1007/s00109-014-1178-6. PMID: 24893666

Diagnosis

Histologic Abnormalities of the Ascending Aorta: Effects on Aortic Remodeling after Intracardiac Repair of Tetralogy of Fallot.
Chowdhury UK, Sankhyan LK, Avneesh S, Ray R, Kalaivani M, Hasija S, Chauhan A
Tex Heart Inst J 2020 Apr 1;47(2):86-95. doi: 10.14503/THIJ-17-6279. PMID: 32603461Free PMC Article
Semicarbazide-sensitive amine oxidase in annulo-aortic ectasia disease: relation to elastic lamellae-associated proteins.
Sibon I, Larrieu D, El Hadri K, Mercier N, Fève B, Lacolley P, Labat C, Daret D, Bonnet J, Lamazière JM
J Histochem Cytochem 2004 Nov;52(11):1459-66. doi: 10.1369/jhc.4A6252.2004. PMID: 15505340Free PMC Article
7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.
Ares MP, Pörn-Ares MI, Moses S, Thyberg J, Juntti-Berggren L, Berggren P, Hultgårdh-Nilsson A, Kallin B, Nilsson J
Atherosclerosis 2000 Nov;153(1):23-35. doi: 10.1016/s0021-9150(00)00380-4. PMID: 11058697

Therapy

Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.
Fabian O, Gebauer R, Koblizek M, Hornofova L, Janousek J
Cardiovasc Pathol 2019 May-Jun;40:59-64. Epub 2019 Feb 28 doi: 10.1016/j.carpath.2019.02.004. PMID: 30904751
Brain cytoplasmic RNA 1 suppresses smooth muscle differentiation and vascular development in mice.
Wang YC, Chuang YH, Shao Q, Chen JF, Chen SY
J Biol Chem 2018 Apr 13;293(15):5668-5678. Epub 2018 Feb 21 doi: 10.1074/jbc.RA117.001578. PMID: 29467228Free PMC Article

Prognosis

A Novel Recurrent COL5A1 Genetic Variant Is Associated With a Dysplasia-Associated Arterial Disease Exhibiting Dissections and Fibromuscular Dysplasia.
Richer J, Hill HL, Wang Y, Yang ML, Hunker KL, Lane J, Blackburn S, Coleman DM, Eliason J, Sillon G, D'Agostino MD, Jetty P, Mongeon FP, Laberge AM, Ryan SE, Fendrikova-Mahlay N, Coutinho T, Mathis MR, Zawistowski M, Hazen SL, Katz AE, Gornik HL, Brummett CM, Abecasis G, Bergin IL, Stanley JC, Li JZ, Ganesh SK
Arterioscler Thromb Vasc Biol 2020 Nov;40(11):2686-2699. Epub 2020 Sep 17 doi: 10.1161/ATVBAHA.119.313885. PMID: 32938213Free PMC Article
Histologic Abnormalities of the Ascending Aorta: Effects on Aortic Remodeling after Intracardiac Repair of Tetralogy of Fallot.
Chowdhury UK, Sankhyan LK, Avneesh S, Ray R, Kalaivani M, Hasija S, Chauhan A
Tex Heart Inst J 2020 Apr 1;47(2):86-95. doi: 10.14503/THIJ-17-6279. PMID: 32603461Free PMC Article
Histopathological evidence of aortopathy in newborns and infants with Tetralogy of Fallot at the time of the surgical repair.
Fabian O, Gebauer R, Koblizek M, Hornofova L, Janousek J
Cardiovasc Pathol 2019 May-Jun;40:59-64. Epub 2019 Feb 28 doi: 10.1016/j.carpath.2019.02.004. PMID: 30904751

Clinical prediction guides

A Novel Recurrent COL5A1 Genetic Variant Is Associated With a Dysplasia-Associated Arterial Disease Exhibiting Dissections and Fibromuscular Dysplasia.
Richer J, Hill HL, Wang Y, Yang ML, Hunker KL, Lane J, Blackburn S, Coleman DM, Eliason J, Sillon G, D'Agostino MD, Jetty P, Mongeon FP, Laberge AM, Ryan SE, Fendrikova-Mahlay N, Coutinho T, Mathis MR, Zawistowski M, Hazen SL, Katz AE, Gornik HL, Brummett CM, Abecasis G, Bergin IL, Stanley JC, Li JZ, Ganesh SK
Arterioscler Thromb Vasc Biol 2020 Nov;40(11):2686-2699. Epub 2020 Sep 17 doi: 10.1161/ATVBAHA.119.313885. PMID: 32938213Free PMC Article
Histologic Abnormalities of the Ascending Aorta: Effects on Aortic Remodeling after Intracardiac Repair of Tetralogy of Fallot.
Chowdhury UK, Sankhyan LK, Avneesh S, Ray R, Kalaivani M, Hasija S, Chauhan A
Tex Heart Inst J 2020 Apr 1;47(2):86-95. doi: 10.14503/THIJ-17-6279. PMID: 32603461Free PMC Article
Smooth muscle titin forms in vitro amyloid aggregates.
Bobylev AG, Galzitskaya OV, Fadeev RS, Bobyleva LG, Yurshenas DA, Molochkov NV, Dovidchenko NV, Selivanova OM, Penkov NV, Podlubnaya ZA, Vikhlyantsev IM
Biosci Rep 2016 Jul;36(3) Epub 2016 May 20 doi: 10.1042/BSR20160066. PMID: 27129292Free PMC Article
Granulocyte macrophage colony-stimulating factor deficiency affects vascular elastin production and integrity of elastic lamellae.
Weissen-Plenz G, Eschert H, Volker W, Sindermann JR, Beissert S, Robenek H, Scheld HH, Breithardt G
J Vasc Res 2008;45(2):103-10. Epub 2007 Oct 12 doi: 10.1159/000109819. PMID: 17934321

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