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Abnormality of circulating glucocorticoid level

MedGen UID:
868638
•Concept ID:
C4023038
•
Anatomical Abnormality
HPO: HP:0012111

Definition

An abnormality of the concentration of a glucocorticoid in the blood. [from HPO]

Professional guidelines

PubMed

Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management.
Scaroni C, Zilio M, Foti M, Boscaro M
Endocr Rev 2017 Jun 1;38(3):189-219. doi: 10.1210/er.2016-1105. PMID: 28368467
Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia.
Zhou J, Zhou Y, Wen J, Sun X, Zhang X
Braz J Med Biol Res 2017 Feb 16;50(2):e5637. doi: 10.1590/1414-431X20165637. PMID: 28225866Free PMC Article
Low dose prednisolone or oestrogen in the treatment of women with late onset or persistent acne vulgaris.
Darley CR, Moore JW, Besser GM, Munro DD, Kirby JD
Br J Dermatol 1983 Mar;108(3):345-53. doi: 10.1111/j.1365-2133.1983.tb03974.x. PMID: 6219691

Recent clinical studies

Etiology

Glucose and lipid metabolism abnormalities in Cushing's syndrome.
Salehidoost R, Korbonits M
J Neuroendocrinol 2022 Aug;34(8):e13143. Epub 2022 Aug 18 doi: 10.1111/jne.13143. PMID: 35980242
New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy.
Yang J, Chen Y, Li X, Xu D
Heart Fail Rev 2022 Jul;27(4):1431-1441. Epub 2021 Aug 28 doi: 10.1007/s10741-021-10158-x. PMID: 34455516
Glucocorticoids and 11β-hydroxysteroid dehydrogenases: mechanisms for hypertension.
Hunter RW, Bailey MA
Curr Opin Pharmacol 2015 Apr;21:105-14. Epub 2015 Feb 6 doi: 10.1016/j.coph.2015.01.005. PMID: 25666420
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling.
Henley DE, Lightman SL
Clin Endocrinol (Oxf) 2014 May;80(5):621-8. Epub 2014 Feb 25 doi: 10.1111/cen.12422. PMID: 24611992

Diagnosis

Alpha-Klotho protein in systemic lupus erythematosus.
Martín-González C, Gómez-Bernal F, Quevedo-Abeledo JC, Ferrer-Moure C, Espelosín-Ortega E, González-Gay MÁ, Ferraz-Amaro I
Clin Exp Rheumatol 2023 Jan;41(1):41-47. Epub 2022 Mar 11 doi: 10.55563/clinexprheumatol/salqon. PMID: 35349421
Glucose and lipid metabolism abnormalities in Cushing's syndrome.
Salehidoost R, Korbonits M
J Neuroendocrinol 2022 Aug;34(8):e13143. Epub 2022 Aug 18 doi: 10.1111/jne.13143. PMID: 35980242
Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management.
Scaroni C, Zilio M, Foti M, Boscaro M
Endocr Rev 2017 Jun 1;38(3):189-219. doi: 10.1210/er.2016-1105. PMID: 28368467
Pregnancy complicated with agranulocytosis.
Wang H, Sun JL, Zhang ZL, Pei HH
Medicine (Baltimore) 2016 Dec;95(52):e5717. doi: 10.1097/MD.0000000000005717. PMID: 28033275Free PMC Article
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706

Therapy

Combined therapy of prednisone and mTOR inhibitor sirolimus for treating retroperitoneal fibrosis.
Gao H, Liu S, Mai Y, Wang Y, Zhang X, Zheng S, Luo C, Pan C
Ann Rheum Dis 2023 May;82(5):688-697. Epub 2023 Jan 31 doi: 10.1136/ard-2022-223736. PMID: 36720581Free PMC Article
New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy.
Yang J, Chen Y, Li X, Xu D
Heart Fail Rev 2022 Jul;27(4):1431-1441. Epub 2021 Aug 28 doi: 10.1007/s10741-021-10158-x. PMID: 34455516
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
Cardio-metabolic consequences of glucocorticoid replacement: relevance of ultradian signalling.
Henley DE, Lightman SL
Clin Endocrinol (Oxf) 2014 May;80(5):621-8. Epub 2014 Feb 25 doi: 10.1111/cen.12422. PMID: 24611992
Glucocorticoids. Mood, memory, and mechanisms.
Wolkowitz OM, Burke H, Epel ES, Reus VI
Ann N Y Acad Sci 2009 Oct;1179:19-40. doi: 10.1111/j.1749-6632.2009.04980.x. PMID: 19906230

Prognosis

The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Circulating level of Th17 cells is associated with sensitivity to glucocorticoids in patients with immune thrombocytopenia.
Zhang Y, Ma T, Zhou X, Chen J, Li J
Int J Hematol 2018 Apr;107(4):442-450. Epub 2018 Jan 11 doi: 10.1007/s12185-017-2392-0. PMID: 29327325
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
The role of the adrenal cortex in polycystic ovary syndrome.
Moran C, Azziz R
Obstet Gynecol Clin North Am 2001 Mar;28(1):63-75. doi: 10.1016/s0889-8545(05)70185-6. PMID: 11293004
Visceral obesity and diabetes.
Björntorp P, Rosmond R
Drugs 1999;58 Suppl 1:13-8; discussion 75-82. doi: 10.2165/00003495-199958001-00005. PMID: 10576519

Clinical prediction guides

Alpha-Klotho protein in systemic lupus erythematosus.
Martín-González C, Gómez-Bernal F, Quevedo-Abeledo JC, Ferrer-Moure C, Espelosín-Ortega E, González-Gay MÁ, Ferraz-Amaro I
Clin Exp Rheumatol 2023 Jan;41(1):41-47. Epub 2022 Mar 11 doi: 10.55563/clinexprheumatol/salqon. PMID: 35349421
Cerebral blood flow self-regulation in depression.
Liu M, He E, Fu X, Gong S, Han Y, Deng F
J Affect Disord 2022 Apr 1;302:324-331. Epub 2022 Jan 13 doi: 10.1016/j.jad.2022.01.057. PMID: 35032508
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Glucocorticoids. Mood, memory, and mechanisms.
Wolkowitz OM, Burke H, Epel ES, Reus VI
Ann N Y Acad Sci 2009 Oct;1179:19-40. doi: 10.1111/j.1749-6632.2009.04980.x. PMID: 19906230
Visceral obesity and diabetes.
Björntorp P, Rosmond R
Drugs 1999;58 Suppl 1:13-8; discussion 75-82. doi: 10.2165/00003495-199958001-00005. PMID: 10576519

Recent systematic reviews

Budesonide for Protein Losing Enteropathy in Patients with Fontan Circulation: A Systematic Review and Meta-Analysis.
Kewcharoen J, Mekraksakit P, Limpruttidham N, Kanitsoraphan C, Charoenpoonsiri N, Poonsombudlert K, Pattison RJ, Rattanawong P
World J Pediatr Congenit Heart Surg 2020 Jan;11(1):85-91. doi: 10.1177/2150135119872196. PMID: 31835979

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