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Abnormal circulating deoxycorticosterone level

MedGen UID:
1390580
•Concept ID:
C4477025
•
Finding
HPO: HP:0031186

Definition

An abnormality of the concentration of deoxycorticosterone in the blood. Deoxycorticosterone comprises 11-deoxycorticosterone and 21-deoxycorticosterone. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating deoxycorticosterone level

Professional guidelines

PubMed

Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients.
Qin F, Liu K, Zhang C, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y, Zhou X, Jiang X, Wu H, Hui R, Wang J, Zhang H, Song L
Hypertens Res 2019 Oct;42(10):1536-1543. Epub 2019 Aug 6 doi: 10.1038/s41440-019-0306-7. PMID: 31388123

Recent clinical studies

Etiology

Interaction between accumulated 21-deoxysteroids and mineralocorticoid signaling in 21-hydroxylase deficiency.
Travers S, Bouvattier C, Fagart J, Martinerie L, Viengchareun S, Pussard E, Lombès M
Am J Physiol Endocrinol Metab 2020 Feb 1;318(2):E102-E110. Epub 2019 Dec 10 doi: 10.1152/ajpendo.00368.2019. PMID: 31821037
Myocardial fibrosis and the concepts of cardioprotection and cardioreparation.
Weber KT, Brilla CG, Campbell SE, Reddy HK
J Hypertens Suppl 1992 Jul;10(5):S87-94. PMID: 1403238

Diagnosis

A proof of concept of a machine learning algorithm to predict late-onset 21-hydroxylase deficiency in children with premature pubic hair.
Agnani H, Bachelot G, Eguether T, Ribault B, Fiet J, Le Bouc Y, Netchine I, Houang M, Lamazière A
J Steroid Biochem Mol Biol 2022 Jun;220:106085. Epub 2022 Mar 12 doi: 10.1016/j.jsbmb.2022.106085. PMID: 35292353
Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients.
Qin F, Liu K, Zhang C, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y, Zhou X, Jiang X, Wu H, Hui R, Wang J, Zhang H, Song L
Hypertens Res 2019 Oct;42(10):1536-1543. Epub 2019 Aug 6 doi: 10.1038/s41440-019-0306-7. PMID: 31388123
Hypertension due to 17alpha-hydroxylase deficiency.
Wang C, Yeung RT, Coghlan JP, Oddie CJ, Scoggins BA, Stockigt JR
Aust N Z J Med 1978 Jun;8(3):295-9. doi: 10.1111/j.1445-5994.1978.tb04528.x. PMID: 308800

Therapy

Primary aldosteronism treated by trilostane (3 beta-hydroxysteroid dehydrogenase inhibitor).
Nakada T, Kazama T, Koike H, Yoshikawa M, Ishikawa S, Katayama T
Urology 1985 Feb;25(2):207-14. doi: 10.1016/0090-4295(85)90548-5. PMID: 2982227

Prognosis

A proof of concept of a machine learning algorithm to predict late-onset 21-hydroxylase deficiency in children with premature pubic hair.
Agnani H, Bachelot G, Eguether T, Ribault B, Fiet J, Le Bouc Y, Netchine I, Houang M, Lamazière A
J Steroid Biochem Mol Biol 2022 Jun;220:106085. Epub 2022 Mar 12 doi: 10.1016/j.jsbmb.2022.106085. PMID: 35292353

Clinical prediction guides

A proof of concept of a machine learning algorithm to predict late-onset 21-hydroxylase deficiency in children with premature pubic hair.
Agnani H, Bachelot G, Eguether T, Ribault B, Fiet J, Le Bouc Y, Netchine I, Houang M, Lamazière A
J Steroid Biochem Mol Biol 2022 Jun;220:106085. Epub 2022 Mar 12 doi: 10.1016/j.jsbmb.2022.106085. PMID: 35292353
Peripheral neurogenic mechanisms in deoxycorticosterone acetate--salt hypertension in the rat.
de Champlain J, Eid H, Drolet G, Bouvier M, Foucart S
Can J Physiol Pharmacol 1989 Sep;67(9):1140-5. doi: 10.1139/y89-181. PMID: 2688861

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