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Lip hyperpigmentation

MedGen UID:
867578
•Concept ID:
C4021963
•
Anatomical Abnormality
Synonyms: Darkening of skin of the lips; Hyperpigmentation of lip vermillion; Increased pigmentation on the lips
 
HPO: HP:0100816

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip hyperpigmentation

Professional guidelines

PubMed

A Probable Case of Mucosal Fixed Drug Eruption Following Treatment with Silodosin.
Klimi E
Sultan Qaboos Univ Med J 2018 Aug;18(3):e402-e404. Epub 2018 Dec 19 doi: 10.18295/squmj.2018.18.03.025. PMID: 30607288Free PMC Article
Eighteen cases of soft tissue atrophy after intralesional bleomycin a5 injections for the treatment of infantile hemangiomas: a long-term follow-up.
Qiu Y, Lin X, Ma G, Chang L, Jin Y, Chen H, Hu X
Pediatr Dermatol 2015 Mar-Apr;32(2):188-91. Epub 2015 Jan 30 doi: 10.1111/pde.12422. PMID: 25640925
Nitrogen plasma skin regeneration and aesthetic facial surgery: multicenter evaluation of concurrent treatment.
Holcomb JD, Kent KJ, Rousso DE
Arch Facial Plast Surg 2009 May-Jun;11(3):184-93. doi: 10.1001/archfacial.2009.29. PMID: 19451453

Recent clinical studies

Etiology

Q-switched 532 nm Nd:YAG laser therapy for physiological lip hyperpigmentation: novel classification, efficacy, and safety.
Altalhab S, Aljamal M, Mubki T, AlNomair N, Algoblan S, Alalola A, AlJasser MI, Alissa A
J Dermatolog Treat 2022 May;33(3):1324-1328. Epub 2020 Aug 12 doi: 10.1080/09546634.2020.1805400. PMID: 32748662
Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial.
Limpjaroenviriyakul N, Jurairattanaporn N, Kamanamool N, Rojhirunsakool S, Kanokrungsee S, Udompataikul M
Lasers Med Sci 2020 Feb;35(1):165-171. Epub 2019 Jun 8 doi: 10.1007/s10103-019-02814-4. PMID: 31177406
Oral findings in chronic kidney disease: implications for management in developing countries.
Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA
BMC Oral Health 2015 Feb 20;15:24. doi: 10.1186/s12903-015-0004-z. PMID: 25888327Free PMC Article

Diagnosis

Q-switched 532 nm Nd:YAG laser therapy for physiological lip hyperpigmentation: novel classification, efficacy, and safety.
Altalhab S, Aljamal M, Mubki T, AlNomair N, Algoblan S, Alalola A, AlJasser MI, Alissa A
J Dermatolog Treat 2022 May;33(3):1324-1328. Epub 2020 Aug 12 doi: 10.1080/09546634.2020.1805400. PMID: 32748662
Oral findings in chronic kidney disease: implications for management in developing countries.
Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA
BMC Oral Health 2015 Feb 20;15:24. doi: 10.1186/s12903-015-0004-z. PMID: 25888327Free PMC Article
Familial glucocorticoid deficiency: a diagnostic challenge during acute illness.
Habeb AM, Hughes CR, Al-Arabi R, Al-Muhamadi A, Clark AJ, Metherell LA
Eur J Pediatr 2013 Oct;172(10):1407-10. Epub 2013 May 26 doi: 10.1007/s00431-013-2044-1. PMID: 23708259
Approaches to the evaluation of lip hyperpigmentation.
Vachiramon V, McMichael AJ
Int J Dermatol 2012 Jul;51(7):761-70. doi: 10.1111/j.1365-4632.2011.05272.x. PMID: 22715817
Asymptomatic lower lip hyperpigmentation from Laugier-Hunziker syndrome.
Kosari P, Kelly KM
Cutis 2011 Nov;88(5):235-6. PMID: 22272486

Therapy

The Efficacy and Safety of a 755-nm Picosecond Laser in the Treatment of Physiologic Lip Hyperpigmentation in Thai Patients.
Ng JNC, Manuskiatti W, Apinuntham C, Yan C
Dermatol Surg 2022 Nov 1;48(11):1210-1214. Epub 2022 Aug 29 doi: 10.1097/DSS.0000000000003582. PMID: 36037096
Q-switched 532 nm Nd:YAG laser therapy for physiological lip hyperpigmentation: novel classification, efficacy, and safety.
Altalhab S, Aljamal M, Mubki T, AlNomair N, Algoblan S, Alalola A, AlJasser MI, Alissa A
J Dermatolog Treat 2022 May;33(3):1324-1328. Epub 2020 Aug 12 doi: 10.1080/09546634.2020.1805400. PMID: 32748662
Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial.
Limpjaroenviriyakul N, Jurairattanaporn N, Kamanamool N, Rojhirunsakool S, Kanokrungsee S, Udompataikul M
Lasers Med Sci 2020 Feb;35(1):165-171. Epub 2019 Jun 8 doi: 10.1007/s10103-019-02814-4. PMID: 31177406
Q-switched double-frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation.
Alharbi MA
J Cosmet Dermatol 2019 Dec;18(6):1672-1674. Epub 2019 Apr 9 doi: 10.1111/jocd.12946. PMID: 30964234

Prognosis

Familial glucocorticoid deficiency: a diagnostic challenge during acute illness.
Habeb AM, Hughes CR, Al-Arabi R, Al-Muhamadi A, Clark AJ, Metherell LA
Eur J Pediatr 2013 Oct;172(10):1407-10. Epub 2013 May 26 doi: 10.1007/s00431-013-2044-1. PMID: 23708259

Clinical prediction guides

The Efficacy and Safety of a 755-nm Picosecond Laser in the Treatment of Physiologic Lip Hyperpigmentation in Thai Patients.
Ng JNC, Manuskiatti W, Apinuntham C, Yan C
Dermatol Surg 2022 Nov 1;48(11):1210-1214. Epub 2022 Aug 29 doi: 10.1097/DSS.0000000000003582. PMID: 36037096
Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial.
Limpjaroenviriyakul N, Jurairattanaporn N, Kamanamool N, Rojhirunsakool S, Kanokrungsee S, Udompataikul M
Lasers Med Sci 2020 Feb;35(1):165-171. Epub 2019 Jun 8 doi: 10.1007/s10103-019-02814-4. PMID: 31177406

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