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Abnormal lip morphology

MedGen UID:
389175
•Concept ID:
C2183966
•
Anatomical Abnormality
Synonym: Abnormality of the lip
 
HPO: HP:0000159

Definition

An abnormality of the lip. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal lip morphology

Conditions with this feature

Phlebectasia of lips
MedGen UID:
356962
•Concept ID:
C1868391
•
Disease or Syndrome
See: Condition Record
Phlebectasia of lips

Professional guidelines

PubMed

Cleft Lip and Palate Midfacial Hypoplasia: Criteria to Choose the Treatment.
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Management of the alveolar cleft.
Santiago PE, Schuster LA, Levy-Bercowski D
Clin Plast Surg 2014 Apr;41(2):219-32. doi: 10.1016/j.cps.2014.01.001. PMID: 24607190
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712

Recent clinical studies

Etiology

The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.
Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2019 Oct;54(4):468-476. doi: 10.1002/uog.20844. PMID: 31408229
MR Imaging of the Fetal Face: Comprehensive Review.
Nagarajan M, Sharbidre KG, Bhabad SH, Byrd SE
Radiographics 2018 May-Jun;38(3):962-980. Epub 2018 Apr 13 doi: 10.1148/rg.2018170142. PMID: 29652578
Toward an orofacial gene regulatory network.
Kousa YA, Schutte BC
Dev Dyn 2016 Mar;245(3):220-32. Epub 2015 Sep 17 doi: 10.1002/dvdy.24341. PMID: 26332872Free PMC Article
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Diagnosis

Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.
Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2019 Oct;54(4):468-476. doi: 10.1002/uog.20844. PMID: 31408229
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Postaxial polydactyly.
Aggarwal AN, Goyal MK, Rishi Gupta N
JNMA J Nepal Med Assoc 2009 Apr-Jun;48(174):153-4. PMID: 20387358
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938

Therapy

An overview of cleft lip and palate.
Alois CI, Ruotolo RA
JAAPA 2020 Dec;33(12):17-20. doi: 10.1097/01.JAA.0000721644.06681.06. PMID: 33234889
Ankyloglossia and Other Oral Ties.
Walsh J, McKenna Benoit M
Otolaryngol Clin North Am 2019 Oct;52(5):795-811. Epub 2019 Jul 25 doi: 10.1016/j.otc.2019.06.008. PMID: 31353141
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.
Detsky ME, Jivraj N, Adhikari NK, Friedrich JO, Pinto R, Simel DL, Wijeysundera DN, Scales DC
JAMA 2019 Feb 5;321(5):493-503. doi: 10.1001/jama.2018.21413. PMID: 30721300
Phenocopies.
Lenz W
J Med Genet 1973 Mar;10(1):34-49. doi: 10.1136/jmg.10.1.34. PMID: 4354695Free PMC Article

Prognosis

Congenital Upper Lip Sinus.
Zhang J, Li Z, Pang P
J Craniofac Surg 2024 Jul-Aug 01;35(5):e438-e441. Epub 2024 May 2 doi: 10.1097/SCS.0000000000010138. PMID: 38688013
MR Imaging of the Fetal Face: Comprehensive Review.
Nagarajan M, Sharbidre KG, Bhabad SH, Byrd SE
Radiographics 2018 May-Jun;38(3):962-980. Epub 2018 Apr 13 doi: 10.1148/rg.2018170142. PMID: 29652578
"Pitted" lesions in dermatology.
Adya KA, Inamadar AC, Palit A
Int J Dermatol 2017 Jan;56(1):3-17. Epub 2016 Sep 9 doi: 10.1111/ijd.13358. PMID: 27613605
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712

Clinical prediction guides

Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Three-Dimensional Analysis of Definitive Secondary Unilateral Cleft Rhinoplasty Using Cartilage Graft.
Hantawornchaikit T, Arayasantiparb R, Kc K, Boonsiriseth K
Cleft Palate Craniofac J 2022 Aug;59(8):1072-1078. Epub 2021 Aug 17 doi: 10.1177/10556656211034099. PMID: 34402317
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
The telecanthus-hypospadias syndrome.
Stevens CA, Wilroy RS Jr
J Med Genet 1988 Aug;25(8):536-42. doi: 10.1136/jmg.25.8.536. PMID: 3050099Free PMC Article

Recent systematic reviews

Congenital Upper Lip Sinus.
Zhang J, Li Z, Pang P
J Craniofac Surg 2024 Jul-Aug 01;35(5):e438-e441. Epub 2024 May 2 doi: 10.1097/SCS.0000000000010138. PMID: 38688013
Effectiveness of pre-surgical orthopedics on patients with cleft lip and palate: A systematic review and meta-analysis.
Dallaserra M, Pantoja T, Salazar J, Araya I, Yanine N, Villanueva J
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e506-e520. Epub 2022 Feb 10 doi: 10.1016/j.jormas.2022.02.004. PMID: 35151895
Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis.
Berrocal C, Terrero-Pérez Á, Peralta-Mamani M, Fischer Rubira-Bullen IR, Honório HM, de Carvalho IMM, Alvares Capelozza AL
Dentomaxillofac Radiol 2019 Dec;48(8):20190085. Epub 2019 Jul 23 doi: 10.1259/dmfr.20190085. PMID: 31271540Free PMC Article
Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.
Detsky ME, Jivraj N, Adhikari NK, Friedrich JO, Pinto R, Simel DL, Wijeysundera DN, Scales DC
JAMA 2019 Feb 5;321(5):493-503. doi: 10.1001/jama.2018.21413. PMID: 30721300
Dental implants in cleft lip, alveolus, and palate patients: a systematic review.
Wermker K, Jung S, Joos U, Kleinheinz J
Int J Oral Maxillofac Implants 2014 Mar-Apr;29(2):384-90. doi: 10.11607/jomi.3303. PMID: 24683564

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