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Abnormal circulating creatine concentration

MedGen UID:
866482
•Concept ID:
C4020731
•
Finding
Synonyms: Abnormality of creatine metabolism; Creatine metabolism abnormal
 
HPO: HP:0012113

Definition

A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarily for muscle cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating creatine concentration

Recent clinical studies

Etiology

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350

Diagnosis

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Imaging and epilepsy.
Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380
Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.
Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

Therapy

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation.
Ferreira CA, Vicente WV, Evora PR, Rodrigues AJ, Klamt JG, Carlotti AP, Carmona F, Manso PH
Rev Bras Cir Cardiovasc 2009 Oct-Dec;24(4):519-32. doi: 10.1590/s0102-76382009000500014. PMID: 20305926
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution.
Przybelski RJ, Daily EK, Kisicki JC, Mattia-Goldberg C, Bounds MJ, Colburn WA
Crit Care Med 1996 Dec;24(12):1993-2000. doi: 10.1097/00003246-199612000-00011. PMID: 8968267

Prognosis

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Skeletal muscle metabolism in patients with congestive heart failure: relation to clinical severity and blood flow.
Massie B, Conway M, Yonge R, Frostick S, Ledingham J, Sleight P, Radda G, Rajagopalan B
Circulation 1987 Nov;76(5):1009-19. doi: 10.1161/01.cir.76.5.1009. PMID: 3664989
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

Clinical prediction guides

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350
Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.
Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739
Creatine kinase BB: a new tumor-associated marker.
Silverman LM, Dermer GB, Zweig MH, Van Steirteghem AC, Tökés ZA
Clin Chem 1979 Aug;25(8):1432-5. PMID: 455680

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