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Transient global amnesia(TGA)

MedGen UID:
83275
•Concept ID:
C0338591
•
Mental or Behavioral Dysfunction
Synonyms: TGA; Transient global amnesia (disease)
SNOMED CT: Transient global amnesia (230736007); TGA - transient global amnesia (230736007)
 
HPO: HP:0010534
Monarch Initiative: MONDO:0001617

Definition

A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient global amnesia

Professional guidelines

PubMed

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Transient global amnesia: emergency department evaluation and management [digest].
Faust JS, Nemes A, Zaurova M
Emerg Med Pract 2016 Aug 22;18(8 Suppl Points & Pearls):S1-S2. PMID: 28745847
Transient Global Amnesia: Emergency Department Evaluation And Management.
Faust JS, Nemes A
Emerg Med Pract 2016 Aug;18(8):1-20. Epub 2016 Aug 1 PMID: 27416582

Recent clinical studies

Etiology

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Transient Global Amnesia.
Sealy D, Tiller RJ, Johnson K
Am Fam Physician 2022 Jan 1;105(1):50-54. PMID: 35029951
SREDA: A Rare but Confusing Benign EEG Variant.
Azman Iste F, Tezer Filik FI, Saygi S
J Clin Neurophysiol 2020 May;37(3):225-230. doi: 10.1097/WNP.0000000000000623. PMID: 31393275
Transient global amnesia.
Arena JE, Rabinstein AA
Mayo Clin Proc 2015 Feb;90(2):264-72. doi: 10.1016/j.mayocp.2014.12.001. PMID: 25659242
Transient global amnesia.
Frederiks JA
Clin Neurol Neurosurg 1993 Dec;95(4):265-83. doi: 10.1016/0303-8467(93)90102-m. PMID: 8299284

Diagnosis

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Transient Global Amnesia.
Ropper AH
N Engl J Med 2023 Feb 16;388(7):635-640. doi: 10.1056/NEJMra2213867. PMID: 36791163
Acute-onset amnesia: transient global amnesia and other causes.
Miller TD, Butler CR
Pract Neurol 2022 Jun;22(3):201-208. Epub 2022 May 3 doi: 10.1136/practneurol-2020-002826. PMID: 35504698
Transient Global Amnesia.
Sealy D, Tiller RJ, Johnson K
Am Fam Physician 2022 Jan 1;105(1):50-54. PMID: 35029951
Transient global amnesia.
Williamson J, Larner AJ
Br J Hosp Med (Lond) 2015 Dec;76(12):C186-8. doi: 10.12968/hmed.2015.76.12.C186. PMID: 26646345

Therapy

Transient global amnesia - hippocampal lesions in magnetic resonance imaging.
Golenia A, Ferens A, Kolasa A, Ignatiuk A, Kostera-Pruszczyk A
J Stroke Cerebrovasc Dis 2023 Mar;32(3):106951. Epub 2022 Dec 22 doi: 10.1016/j.jstrokecerebrovasdis.2022.106951. PMID: 36565520
Hippocampal infarction: redefining transient global amnesia.
Santana J, García-Alfonso C, Martínez A, Cárdenas-Cruz AF, Aguilera-Pena MP, Bris-Fernández Ó, Waich A, Del Mar Talero-Munoz M, Coral J
Neurol Sci 2022 Jul;43(7):4281-4286. Epub 2022 Mar 4 doi: 10.1007/s10072-022-05980-6. PMID: 35244830
Medical Procedure-Related Transient Global Amnesia.
Jeong M, Kim WS, Kim AR, Park JJ, Choi DH, Kim HY
Eur Neurol 2018;80(1-2):42-49. Epub 2018 Sep 11 doi: 10.1159/000493163. PMID: 30205365
Pharmacological modulation of spreading depolarizations.
Sánchez-Porras R, Zheng Z, Sakowitz OW
Acta Neurochir Suppl 2015;120:153-7. doi: 10.1007/978-3-319-04981-6_26. PMID: 25366616
Amnesia.
Benson DF
South Med J 1978 Oct;71(10):1221-7, 1231. doi: 10.1097/00007611-197810000-00011. PMID: 360401

Prognosis

Acute-onset amnesia: transient global amnesia and other causes.
Miller TD, Butler CR
Pract Neurol 2022 Jun;22(3):201-208. Epub 2022 May 3 doi: 10.1136/practneurol-2020-002826. PMID: 35504698
Transient global amnesia: Model, mechanism, hypothesis.
Larner AJ
Cortex 2022 Apr;149:137-147. Epub 2022 Jan 31 doi: 10.1016/j.cortex.2022.01.011. PMID: 35228100
Transient global amnesia.
Arena JE, Rabinstein AA
Mayo Clin Proc 2015 Feb;90(2):264-72. doi: 10.1016/j.mayocp.2014.12.001. PMID: 25659242
Transient global amnesia.
Marazzi C, Scoditti U, Ticinesi A, Nouvenne A, Pigna F, Guida L, Morelli I, Borghi L, Meschi T
Acta Biomed 2014 Dec 17;85(3):229-35. PMID: 25567459
Amnesic disorders.
Markowitsch HJ, Staniloiu A
Lancet 2012 Oct 20;380(9851):1429-40. Epub 2012 Apr 13 doi: 10.1016/S0140-6736(11)61304-4. PMID: 22503117

Clinical prediction guides

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Transient global amnesia: Model, mechanism, hypothesis.
Larner AJ
Cortex 2022 Apr;149:137-147. Epub 2022 Jan 31 doi: 10.1016/j.cortex.2022.01.011. PMID: 35228100
Chronobiology of transient global amnesia.
Hoyer C, Higashida K, Fabbian F, De Giorgi A, Sandikci V, Ebert A, Platten M, Okazaki S, Manfredini R, Szabo K
J Neurol 2022 Jan;269(1):361-367. Epub 2021 Jun 8 doi: 10.1007/s00415-021-10639-x. PMID: 34104990Free PMC Article
SREDA: A Rare but Confusing Benign EEG Variant.
Azman Iste F, Tezer Filik FI, Saygi S
J Clin Neurophysiol 2020 May;37(3):225-230. doi: 10.1097/WNP.0000000000000623. PMID: 31393275
Transient Global Amnesia: Emergency Department Evaluation And Management.
Faust JS, Nemes A
Emerg Med Pract 2016 Aug;18(8):1-20. Epub 2016 Aug 1 PMID: 27416582

Recent systematic reviews

Transient global amnesia with unexpected clinical and radiological findings: A case series and systematic review.
Piffer S, Nannoni S, Maulucci F, Beaud V, Rouaud O, Förster A, Cereda CW, Maeder P, Michel P
J Neurol Sci 2022 Oct 15;441:120349. Epub 2022 Jul 23 doi: 10.1016/j.jns.2022.120349. PMID: 35944401
Acute neurological disease as a trigger or co-occurrence of transient global amnesia: a case series and systematic review.
Piffer S, Nannoni S, Maulucci F, Beaud V, Rouaud O, Cereda CW, Maeder P, Michel P
Neurol Sci 2022 Oct;43(10):5959-5967. Epub 2022 Jul 15 doi: 10.1007/s10072-022-06259-6. PMID: 35838848
Factors associated with recurrent transient global amnesia: systematic review and pathophysiological insights.
Liampas I, Raptopoulou M, Mpourlios S, Siokas V, Tsouris Z, Aloizou AM, Dastamani M, Brotis A, Bogdanos D, Xiromerisiou G, Dardiotis E
Rev Neurosci 2021 Nov 25;32(7):751-765. Epub 2021 Mar 8 doi: 10.1515/revneuro-2021-0009. PMID: 33675214
The long-term prognosis of Transient Global Amnesia: a systematic review.
Liampas I, Raptopoulou M, Siokas V, Tsouris Z, Brotis A, Aloizou AM, Dastamani M, Dardiotis E
Rev Neurosci 2021 Jul 27;32(5):531-543. Epub 2021 Feb 1 doi: 10.1515/revneuro-2020-0110. PMID: 33550779
Conventional cardiovascular risk factors in Transient Global Amnesia: Systematic review and proposition of a novel hypothesis.
Liampas I, Raptopoulou M, Siokas V, Bakirtzis C, Tsouris Z, Aloizou AM, Dastamani M, Brotis A, Bogdanos D, Dardiotis E
Front Neuroendocrinol 2021 Apr;61:100909. Epub 2021 Feb 2 doi: 10.1016/j.yfrne.2021.100909. PMID: 33539928

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