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Uveal Spindle Cell Type A Melanoma

MedGen UID:
234808
•Concept ID:
C1336054
•
Neoplastic Process
Synonyms: Spindle Cell Type A Melanoma of the Uvea; Spindle Cell Type A Melanoma of Uvea; Spindle Cell Type A Uveal Melanoma

Definition

A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal Spindle Cell Type A Melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns.
Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chévez-Barrios P, Larsen P, Majumdar D, Pe'er J, Maniotis AJ
Am J Pathol 2006 Oct;169(4):1376-89. doi: 10.2353/ajpath.2006.060223. PMID: 17003493Free PMC Article
HLA Class I and II genotype in uveal melanoma: relation to occurrence and prognosis.
Maat W, Haasnoot GW, Claas FH, Schalij-Delfos NE, Schreuder GM, Jager MJ
Invest Ophthalmol Vis Sci 2006 Jan;47(1):3-6. doi: 10.1167/iovs.05-1122. PMID: 16384937

Recent clinical studies

Therapy

Utility of next-generation sequencing in the diagnosis of metastatic melanoma: A case report.
Turcios Escobar S, Yang R, Nelson KC, Gershenwald JE, Tawbi H, Aung PP, Patel SP, Torres-Cabala CA
J Cutan Pathol 2024 Sep;51(9):644-648. Epub 2024 May 16 doi: 10.1111/cup.14660. PMID: 38757469
The GPER Agonist LNS8801 Induces Mitotic Arrest and Apoptosis in Uveal Melanoma Cells.
Ambrosini G, Natale CA, Musi E, Garyantes T, Schwartz GK
Cancer Res Commun 2023 Apr;3(4):540-547. Epub 2023 Apr 5 doi: 10.1158/2767-9764.CRC-22-0399. PMID: 37035582Free PMC Article
Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Decitabine limits escape from MEK inhibition in uveal melanoma.
Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KSM
Pigment Cell Melanoma Res 2020 May;33(3):507-514. Epub 2019 Dec 6 doi: 10.1111/pcmr.12849. PMID: 31758842Free PMC Article
Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma.
Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689Free PMC Article

Prognosis

Next-generation sequencing of uveal melanoma with clinical and histological correlations: Prognostic value of new mutations in the PI3K/AKT/mTOR pathway.
Pérez-Pérez M, Agostino A, de Sola-Llamas CG, Ruvolo M, Vilches-Arenas A, Relimpio-López MI, Espejo-Arjona F, Macías-García L, De Miguel-Rodríguez M, García-Escudero A, Idoate MA, Ríos-Martín JJ
Clin Exp Ophthalmol 2023 Nov;51(8):822-834. Epub 2023 Oct 6 doi: 10.1111/ceo.14302. PMID: 37803816
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype.
Longhitano L, Giallongo S, Orlando L, Broggi G, Longo A, Russo A, Caltabiano R, Giallongo C, Barbagallo I, Di Rosa M, Giuffrida R, Parenti R, Li Volti G, Vicario N, Tibullo D
Int J Mol Sci 2022 Dec 20;24(1) doi: 10.3390/ijms24010024. PMID: 36613471Free PMC Article
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Clinical prediction guides

Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention.
Sabat-Pośpiech D, Fabian-Kolpanowicz K, Kalirai H, Kipling N, Coupland SE, Coulson JM, Fielding AB
J Pathol Clin Res 2022 Jul;8(4):383-394. Epub 2022 Apr 26 doi: 10.1002/cjp2.272. PMID: 35474453Free PMC Article
Intraocular schwannoma with extrascleral extension.
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864

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