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Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

MedGen UID:
819729
•Concept ID:
C3826981
•
Neoplastic Process
Synonym: Pancreatic MD-IPMN

Definition

An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMain Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

Professional guidelines

PubMed

Updates in diagnosis and management of pancreatic cysts.
Lee LS
World J Gastroenterol 2021 Sep 14;27(34):5700-5714. doi: 10.3748/wjg.v27.i34.5700. PMID: 34629795Free PMC Article
Pancreatic incidentalomas: Investigation and management.
Del Chiaro M, Torphy RJ, Schulick RD
J Intern Med 2021 Nov;290(5):969-979. doi: 10.1111/joim.13359. PMID: 34237168
European evidence-based guidelines on pancreatic cystic neoplasms.
European Study Group on Cystic Tumours of the Pancreas
Gut 2018 May;67(5):789-804. Epub 2018 Mar 24 doi: 10.1136/gutjnl-2018-316027. PMID: 29574408Free PMC Article

Recent clinical studies

Therapy

Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms.
de la Fuente J, Chatterjee A, Lui J, Nehra AK, Bell MG, Lennon RJ, Kassmeyer BA, Graham RP, Nagayama H, Schulte PJ, Doering KA, Delgado AM, Vege SS, Chari ST, Takahashi N, Majumder S
JAMA Netw Open 2023 Oct 2;6(10):e2337799. doi: 10.1001/jamanetworkopen.2023.37799. PMID: 37847503Free PMC Article
Should non-invasive diffuse main-duct intraductal papillary mucinous neoplasms be treated with total pancreatectomy?
Blair AB, Beckman RM, Habib JR, Griffin JF, Lafaro K, Burkhart RA, Burns W, Weiss MJ, Cameron JL, Wolfgang CL, He J
HPB (Oxford) 2022 May;24(5):645-653. Epub 2021 Sep 23 doi: 10.1016/j.hpb.2021.09.013. PMID: 34610896Free PMC Article
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
International guidelines for the management of pancreatic intraductal papillary mucinous neoplasms.
Goh BK
World J Gastroenterol 2015 Sep 14;21(34):9833-7. doi: 10.3748/wjg.v21.i34.9833. PMID: 26379390Free PMC Article
Per oral cholangiopancreatoscopy in pancreatico biliary diseases--expert consensus statements.
Ramchandani M, Reddy DN, Lakhtakia S, Tandan M, Maydeo A, Chandrashekhar TS, Kumar A, Sud R, Rerknimitr R, Makmun D, Khor C
World J Gastroenterol 2015 Apr 21;21(15):4722-34. doi: 10.3748/wjg.v21.i15.4722. PMID: 25914484Free PMC Article

Prognosis

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.
Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Humoral Predictors of Malignancy in IPMN: A Review of the Literature.
Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Multicenter study of early pancreatic cancer in Japan.
Kanno A, Masamune A, Hanada K, Maguchi H, Shimizu Y, Ueki T, Hasebe O, Ohtsuka T, Nakamura M, Takenaka M, Kitano M, Kikuyama M, Gabata T, Yoshida K, Sasaki T, Serikawa M, Furukawa T, Yanagisawa A, Shimosegawa T; Japan Study Group on the Early Detection of Pancreatic Cancer (JEDPAC)
Pancreatology 2018 Jan;18(1):61-67. Epub 2017 Nov 20 doi: 10.1016/j.pan.2017.11.007. PMID: 29170051
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article

Clinical prediction guides

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.
Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Humoral Predictors of Malignancy in IPMN: A Review of the Literature.
Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article

Recent systematic reviews

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.
Ohno E, Balduzzi A, Hijioka S, De Pastena M, Marchegiani G, Kato H, Takenaka M, Haba S, Salvia R
Pancreatology 2024 Feb;24(1):48-61. Epub 2023 Dec 7 doi: 10.1016/j.pan.2023.12.002. PMID: 38161091
Association between pancreatic intraductal papillary mucinous neoplasms and extrapancreatic malignancies: A systematic review with meta-analysis.
Facciorusso A, Crinò SF, Ramai D, Marchegiani G, Lester J, Singh J, Lisotti A, Fusaroli P, Cannizzaro R, Gkolfakis P, Papanikolaou IS, Triantafyllou K, Singh S
Eur J Surg Oncol 2022 Mar;48(3):632-639. Epub 2021 Oct 1 doi: 10.1016/j.ejso.2021.09.018. PMID: 34620511
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Diabetes mellitus in intraductal papillary mucinous neoplasms: A systematic review and meta-analysis.
Pergolini I, Schorn S, Jäger C, Göß R, Novotny A, Friess H, Ceyhan GO, Demir IE
Surgery 2021 Feb;169(2):411-418. Epub 2020 Aug 22 doi: 10.1016/j.surg.2020.07.006. PMID: 32838986
Risk factors for post-ERCP pancreatitis: A systematic review and meta-analysis.
Ding X, Zhang F, Wang Y
Surgeon 2015 Aug;13(4):218-29. Epub 2014 Dec 24 doi: 10.1016/j.surge.2014.11.005. PMID: 25547802

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