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Mesothelial neoplasm

MedGen UID:
811450
•Concept ID:
C3714739
•
Neoplastic Process
Synonyms: Mesothelial Neoplasm; Mesothelial Neoplasms; Neoplasm, Mesothelial; Neoplasms, Mesothelial
SNOMED CT: Mesothelial neoplasm (115232000)
 
Monarch Initiative: MONDO:0006856

Definition

A neoplasm characterized by the proliferation of neoplastic mesothelial cells. It usually arises from the pleura or peritoneum. This category includes malignant mesothelioma, adenomatoid tumor (benign mesothelioma), well differentiated papillary mesothelial tumor, and multicystic mesothelioma. [from NCI]

Professional guidelines

PubMed

Differential diagnosis between mesothelioma and adenocarcinoma: a multimodal approach based on ultrastructure and immunocytochemistry.
Bedrossian CW, Bonsib S, Moran C
Semin Diagn Pathol 1992 May;9(2):124-40. PMID: 1609155

Recent clinical studies

Etiology

Synchronous diffuse malignant mesothelioma and carcinomas in asbestos-exposed individuals.
Attanoos RL, Thomas DH, Gibbs AR
Histopathology 2003 Oct;43(4):387-92. doi: 10.1046/j.1365-2559.2003.01685.x. PMID: 14511258

Diagnosis

Adenomatoid tumours of the gastrointestinal tract - a case-series and review of the literature.
Hissong E, Graham RP, Wen KW, Alpert L, Shi J, Lamps LW
Histopathology 2022 Jan;80(2):348-359. Epub 2021 Oct 7 doi: 10.1111/his.14553. PMID: 34480486Free PMC Article
Histological and immunohistochemical characteristics and p16 status studied by FISH in six incidentally detected cases of well-differentiated papillary mesothelioma of the peritoneum.
Fujishima F, Konosu-Fukaya S, Nabeshima K, McNamara KM, Sakamoto K, Sakurada J, Sasano H, Nakamura Y
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):277-281. doi: 10.4103/IJPM.IJPM_111_20. PMID: 33851620
9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis.
Takeda M, Kasai T, Enomoto Y, Takano M, Morita K, Kadota E, Nonomura A
Pathol Int 2010 May;60(5):395-9. doi: 10.1111/j.1440-1827.2010.02534.x. PMID: 20518890
Diffuse intra-abdominal clear cell myomelanocytic tumor: report of an unusual presentation of "PEComatosis" simulating peritoneal mesothelioma.
Salviato T, Altavilla G, Busatto G, Pizzolitto S, Falconieri G
Ann Diagn Pathol 2006 Dec;10(6):352-6. doi: 10.1016/j.anndiagpath.2005.09.019. PMID: 17126254

Therapy

Histological and immunohistochemical characteristics and p16 status studied by FISH in six incidentally detected cases of well-differentiated papillary mesothelioma of the peritoneum.
Fujishima F, Konosu-Fukaya S, Nabeshima K, McNamara KM, Sakamoto K, Sakurada J, Sasano H, Nakamura Y
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):277-281. doi: 10.4103/IJPM.IJPM_111_20. PMID: 33851620
Synchronous diffuse malignant mesothelioma and carcinomas in asbestos-exposed individuals.
Attanoos RL, Thomas DH, Gibbs AR
Histopathology 2003 Oct;43(4):387-92. doi: 10.1046/j.1365-2559.2003.01685.x. PMID: 14511258

Clinical prediction guides

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Stevers M, Rabban JT, Garg K, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Zaloudek C, Solomon DA
Mod Pathol 2019 Jan;32(1):88-99. Epub 2018 Aug 31 doi: 10.1038/s41379-018-0127-2. PMID: 30171198Free PMC Article

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