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Central nervous system nongerminomatous germ cell tumor

MedGen UID:: 760465
•Concept ID:: C1696109
•: Neoplastic Process

Synonyms:	Central Nervous System Nongerminomatous Germ Cell Tumor; central nervous system nongerminomatous germ cell tumor; nongerminomatous GCT - CNS; Nongerminomatous germ cell tumor of central nervous system; nongerminomatous germ cell tumor of the CNS; nongerminomatous germ cell tumour of the CNS
SNOMED CT:	Nongerminomatous germ cell tumor of central nervous system (878808006)

Monarch Initiative:	MONDO:0020574

Definition

Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCentral nervous system nongerminomatous germ cell tumor

Disease
- Neoplasm
  - Neoplasm by Morphology
    - Germ cell tumor
      - Extragonadal germ cell tumor
        Central nervous system germ cell tumor
        Central nervous system nongerminomatous germ cell tumor
        Central nervous system teratoma
        Adult central nervous system teratoma
        Adult central nervous system immature teratoma
        Adult central nervous system mature teratoma
        Central nervous system immature teratoma
        Childhood central nervous system immature teratoma
        Pineal region immature teratoma
        Sellar Immature Teratoma
        Central nervous system mature teratoma
        Central Nervous System Dermoid Cyst
        Childhood central nervous system mature teratoma
        Pineal region mature teratoma
        Sellar Mature Teratoma
        Central Nervous System Teratoma with Malignant Transformation
        Sellar Teratoma with Malignant Transformation
        Childhood Central Nervous System Teratoma
        Pineal region teratoma
        Sellar Teratoma
        Spinal cord intramedullary teratoma
        Choriocarcinoma of the central nervous system
        Adult central nervous system choriocarcinoma
        Pediatric CNS choriocarcinoma
        Pineal region choriocarcinoma
        Sellar Choriocarcinoma
        Embryonal carcinoma of the central nervous system
        Adult central nervous system embryonal carcinoma
        Childhood central nervous system embryonal carcinoma
        Sellar Embryonal Carcinoma
        Yolk sac tumor of central nervous system
        Central nervous system endodermal sinus tumor
        Pineal region yolk sac tumor
        Sellar Yolk Sac Tumor

Professional guidelines

PubMed

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Primary CNS germ cell tumors: current epidemiology and update on treatment.

Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013

Clinical management of primary central nervous system germ cell tumors.

Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121

See all (26)

Recent clinical studies

Etiology

Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome.

Harris MK, Graham RT, Cappellano AM, Margol AS, Michaiel G, Crawford JR, Ioakeim-Ioannidou M, Stanek JR, Liu KX, MacDonald SM, Abdelbaki MS
Pediatr Blood Cancer 2022 Oct;69(10):e29830. Epub 2022 Jun 10 doi: 10.1002/pbc.29830. PMID: 35686831

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.

Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614

Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study.

Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G
J Clin Oncol 2019 Dec 1;37(34):3283-3290. Epub 2019 Sep 23 doi: 10.1200/JCO.19.00701. PMID: 31545689 Free PMC Article

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Primary CNS germ cell tumors: current epidemiology and update on treatment.

Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013

See all (82)

Diagnosis

Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors.

Zhang Y, Zhong C, Ke X, Liu J, Ye Z, Lu L, Deng K, Zhu H, Yao Y
Acta Neuropathol Commun 2023 Nov 27;11(1):188. doi: 10.1186/s40478-023-01682-y. PMID: 38012690 Free PMC Article

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.

Abu-Arja MH, Osorio DS, Lassaletta A, Graham RT, Coven SL, Stanek JR, Bouffet E, Finlay JL, Abdelbaki MS
Pediatr Blood Cancer 2022 Jan;69(1):e29365. Epub 2021 Sep 24 doi: 10.1002/pbc.29365. PMID: 34558189

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.

Central Nervous System Germ Cell Tumors: A Review of the Literature.

Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146

Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature.

Belongia M, Jogal S
J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6. doi: 10.1097/MPH.0b013e31823dd370. PMID: 22215101

See all (99)

Therapy

Advances in Molecular Profiling and Developing Clinical Trials of CNS Germ Cell Tumors: Present and Future Directions.

Takami H
Curr Oncol Rep 2022 Jan;24(1):105-112. Epub 2022 Jan 20 doi: 10.1007/s11912-022-01195-2. PMID: 35059994

A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.

Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM
Int J Radiat Oncol Biol Phys 2022 May 1;113(1):143-151. Epub 2022 Jan 4 doi: 10.1016/j.ijrobp.2021.12.166. PMID: 34990779 Free PMC Article

Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study.

Central nervous system germ cell tumors: controversies in diagnosis and treatment.

Jubran RF, Finlay J
Oncology (Williston Park) 2005 May;19(6):705-11; discussion 711-2, 715-7, 721. PMID: 15971448

Clinical management of primary central nervous system germ cell tumors.

Matsutani M
Semin Oncol 2004 Oct;31(5):676-83. doi: 10.1053/j.seminoncol.2004.07.010. PMID: 15497121

See all (47)

Prognosis

Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors.

Zhang Y, Zhong C, Ke X, Liu J, Ye Z, Lu L, Deng K, Zhu H, Yao Y
Acta Neuropathol Commun 2023 Nov 27;11(1):188. doi: 10.1186/s40478-023-01682-y. PMID: 38012690 Free PMC Article

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Abu Arja MH, Bouffet E, Finlay JL, AbdelBaki MS
Pediatr Blood Cancer 2019 Jun;66(6):e27658. Epub 2019 Feb 15 doi: 10.1002/pbc.27658. PMID: 30767415

Primary CNS germ cell tumors: current epidemiology and update on treatment.

Thakkar JP, Chew L, Villano JL
Med Oncol 2013 Jun;30(2):496. Epub 2013 Feb 24 doi: 10.1007/s12032-013-0496-9. PMID: 23436013

Pediatric central nervous system germ cell tumors: a review.

Echevarría ME, Fangusaro J, Goldman S
Oncologist 2008 Jun;13(6):690-9. doi: 10.1634/theoncologist.2008-0037. PMID: 18586924

See all (79)

Clinical prediction guides

Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors.

Zhang Y, Zhong C, Ke X, Liu J, Ye Z, Lu L, Deng K, Zhu H, Yao Y
Acta Neuropathol Commun 2023 Nov 27;11(1):188. doi: 10.1186/s40478-023-01682-y. PMID: 38012690 Free PMC Article

Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.

Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.

MRI features of pediatric intracranial germ cell tumor subtypes.

Wu CC, Guo WY, Chang FC, Luo CB, Lee HJ, Chen YW, Lee YY, Wong TT
J Neurooncol 2017 Aug;134(1):221-230. Epub 2017 May 27 doi: 10.1007/s11060-017-2513-x. PMID: 28551848

Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.

Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571

See all (28)

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Central nervous system nongerminomatous germ cell tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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