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Iron deficiency

MedGen UID:
66001
Concept ID:
C0240066
Disease or Syndrome
Synonyms: Deficiencies, Iron; Deficiency, Iron; Iron Deficiencies; Iron Deficiency; Sideropenia; Sideropenias
SNOMED CT: Iron deficiency (35240004)

Definition

Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIron deficiency

Professional guidelines

PubMed

Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Cappellini MD, Musallam KM, Taher AT
J Intern Med 2020 Feb;287(2):153-170. Epub 2019 Nov 12 doi: 10.1111/joim.13004. PMID: 31665543
Bellakhal S, Ouertani S, Antit S, Abdelaali I, Teyeb Z, Dougui MH
Tunis Med 2019 Dec;97(12):1389-1398. PMID: 32173810
Camaschella C
Blood 2019 Jan 3;133(1):30-39. Epub 2018 Nov 6 doi: 10.1182/blood-2018-05-815944. PMID: 30401704
Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L
Lancet 2016 Feb 27;387(10021):907-16. Epub 2015 Aug 24 doi: 10.1016/S0140-6736(15)60865-0. PMID: 26314490

Diagnosis

Leung AKC, Lam JM, Wong AHC, Hon KL, Li X
Curr Pediatr Rev 2024;20(3):339-356. doi: 10.2174/1573396320666230727102042. PMID: 37497686
Cappellini MD, Santini V, Braxs C, Shander A
Fertil Steril 2022 Oct;118(4):607-614. Epub 2022 Sep 6 doi: 10.1016/j.fertnstert.2022.08.014. PMID: 36075747
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ
BMJ Open Gastroenterol 2022 Jan;9(1) doi: 10.1136/bmjgast-2021-000759. PMID: 34996762Free PMC Article
Cappellini MD, Musallam KM, Taher AT
J Intern Med 2020 Feb;287(2):153-170. Epub 2019 Nov 12 doi: 10.1111/joim.13004. PMID: 31665543
DeLoughery TG
Med Clin North Am 2017 Mar;101(2):319-332. Epub 2016 Dec 8 doi: 10.1016/j.mcna.2016.09.004. PMID: 28189173

Therapy

McWilliams S, Singh I, Leung W, Stockler S, Ipsiroglu OS
PLoS One 2022;17(9):e0273819. Epub 2022 Sep 29 doi: 10.1371/journal.pone.0273819. PMID: 36173945Free PMC Article
Skolmowska D, Głąbska D, Kołota A, Guzek D
Nutrients 2022 Jul 23;14(15) doi: 10.3390/nu14153023. PMID: 35893877Free PMC Article
Wolf M, Rubin J, Achebe M, Econs MJ, Peacock M, Imel EA, Thomsen LL, Carpenter TO, Weber T, Brandenburg V, Zoller H
JAMA 2020 Feb 4;323(5):432-443. doi: 10.1001/jama.2019.22450. PMID: 32016310Free PMC Article
Gafter-Gvili A, Schechter A, Rozen-Zvi B
Acta Haematol 2019;142(1):44-50. Epub 2019 Apr 10 doi: 10.1159/000496492. PMID: 30970355
Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T
Cochrane Database Syst Rev 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. PMID: 26198451Free PMC Article

Prognosis

Benson AE, Shatzel JJ, Ryan KS, Hedges MA, Martens K, Aslan JE, Lo JO
Eur J Haematol 2022 Dec;109(6):633-642. Epub 2022 Oct 4 doi: 10.1111/ejh.13870. PMID: 36153674Free PMC Article
Mei Z, Addo OY, Jefferds ME, Sharma AJ, Flores-Ayala RC, Brittenham GM
Lancet Haematol 2021 Aug;8(8):e572-e582. doi: 10.1016/S2352-3026(21)00168-X. PMID: 34329578Free PMC Article
Sundararajan S, Rabe H
Pediatr Res 2021 Jan;89(1):63-73. Epub 2020 Apr 24 doi: 10.1038/s41390-020-0907-5. PMID: 32330927
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators
Lancet 2017 Sep 16;390(10100):1211-1259. doi: 10.1016/S0140-6736(17)32154-2. PMID: 28919117Free PMC Article
Carter KA, Hathaway NE, Lettieri CF
Am Fam Physician 2014 Mar 1;89(5):368-77. PMID: 24695508

Clinical prediction guides

Svensson L, Chmielewski G, Czyzewska E, Domellöf M, Konarska Z, Piescik-Lech M, Späth C, Szajewska H, Chmielewska A
JAMA Pediatr 2024 Jul 1;178(7):649-656. doi: 10.1001/jamapediatrics.2024.1095. PMID: 38739382Free PMC Article
Cleland JGF, Kalra PA, Pellicori P, Graham FJ, Foley PWX, Squire IB, Cowburn PJ, Seed A, Clark AL, Szwejkowski B, Banerjee P, Cooke J, Francis M, Clifford P, Wong A, Petrie C, McMurray JJV, Thomson EA, Wetherall K, Robertson M, Ford I, Kalra PR; IRONMAN Study Group
Eur Heart J 2024 Apr 21;45(16):1410-1426. doi: 10.1093/eurheartj/ehae086. PMID: 38446126Free PMC Article
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C
Circulation 2017 Aug 8;136(6):e137-e161. Epub 2017 Apr 28 doi: 10.1161/CIR.0000000000000509. PMID: 28455343
Kujovich JL
Obstet Gynecol Clin North Am 2016 Jun;43(2):247-64. Epub 2016 Mar 18 doi: 10.1016/j.ogc.2016.01.009. PMID: 27212091
Gurvits GE, Lan G
World J Gastroenterol 2014 Dec 21;20(47):17819-29. doi: 10.3748/wjg.v20.i47.17819. PMID: 25548480Free PMC Article

Recent systematic reviews

Skolmowska D, Głąbska D, Kołota A, Guzek D
Nutrients 2022 Jul 23;14(15) doi: 10.3390/nu14153023. PMID: 35893877Free PMC Article
Venkatesh U, Sharma A, Ananthan VA, Subbiah P, Durga R; CSIR Summer Research training team
J Nutr Sci 2021;10:e110. Epub 2021 Dec 21 doi: 10.1017/jns.2021.102. PMID: 35059191Free PMC Article
Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I
World J Gastroenterol 2020 Dec 7;26(45):7242-7257. doi: 10.3748/wjg.v26.i45.7242. PMID: 33362380Free PMC Article
Forbes A, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Bischoff SC
Clin Nutr 2017 Apr;36(2):321-347. Epub 2016 Dec 31 doi: 10.1016/j.clnu.2016.12.027. PMID: 28131521
Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T
Cochrane Database Syst Rev 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. PMID: 26198451Free PMC Article

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