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Abnormal Blood Chemistry and Hematology Test Result

MedGen UID:
233128
•Concept ID:
C1332129
•
Finding

Definition

A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Blood Chemistry and Hematology Test Result

Professional guidelines

PubMed

Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis.
Castaman G, Hillarp A, Goodeve A
Haemophilia 2014 May;20 Suppl 4(0 4):65-70. doi: 10.1111/hae.12410. PMID: 24762278Free PMC Article
The limited utility of screening laboratory tests and electrocardiograms in the management of unintentional asymptomatic pediatric ingestions.
Wang GS, Deakyne S, Bajaj L, Yin S, Heard K, Roosevelt G
J Emerg Med 2013 Jul;45(1):34-8. Epub 2013 Apr 2 doi: 10.1016/j.jemermed.2012.11.056. PMID: 23561311
Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management.
Pardanani A
Am J Hematol 2012 Apr;87(4):401-11. doi: 10.1002/ajh.23134. PMID: 22410759

Recent clinical studies

Etiology

Laboratory Safety from a Randomized 16-Week Phase III Study of Dupilumab in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis.
Paller AS, Siegfried EC, Cork MJ, Wollenberg A, Arkwright PD, Gonzalez ME, Lockshin B, Chen Z, Bansal A, Levit NA, Prescilla R
Paediatr Drugs 2023 Jan;25(1):67-77. Epub 2022 Dec 19 doi: 10.1007/s40272-022-00553-8. PMID: 36529811Free PMC Article
International practice variation in perioperative laboratory testing in glioblastoma patients-a retrospective cohort study.
Senders JT, Maas SLN, Draaisma K, McNulty JJ, Ashby JL, Hofer I, van Solinge WW, Berg MT, Snijders TJ, Seute T, Robe PA, Gormley WB, Smith TR, Broekman MLD
Acta Neurochir (Wien) 2022 Feb;164(2):385-392. Epub 2022 Jan 7 doi: 10.1007/s00701-021-05090-w. PMID: 34997355Free PMC Article
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.
Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G
Clin Chem Lab Med 2020 Jun 25;58(7):1021-1028. doi: 10.1515/cclm-2020-0369. PMID: 32286245
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Diagnosis

Blood compatibility evaluations of CaCO(3)particles.
Lin J, Huang L, Xiang R, Ou H, Li X, Chen A, Liu Z
Biomed Mater 2021 Aug 13;16(5) doi: 10.1088/1748-605X/ac19bf. PMID: 34340221
The chemical and laboratory investigation of hemolysis.
Siddon AJ, Tormey CA
Adv Clin Chem 2019;89:215-258. doi: 10.1016/bs.acc.2018.12.006. PMID: 30797470
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Therapy

Laboratory Safety from a Randomized 16-Week Phase III Study of Dupilumab in Children Aged 6 Months to 5 Years with Moderate-to-Severe Atopic Dermatitis.
Paller AS, Siegfried EC, Cork MJ, Wollenberg A, Arkwright PD, Gonzalez ME, Lockshin B, Chen Z, Bansal A, Levit NA, Prescilla R
Paediatr Drugs 2023 Jan;25(1):67-77. Epub 2022 Dec 19 doi: 10.1007/s40272-022-00553-8. PMID: 36529811Free PMC Article
Blood compatibility evaluations of CaCO(3)particles.
Lin J, Huang L, Xiang R, Ou H, Li X, Chen A, Liu Z
Biomed Mater 2021 Aug 13;16(5) doi: 10.1088/1748-605X/ac19bf. PMID: 34340221
Utility of Routine Preoperative Laboratory Testing for Low-risk Patients in Ambulatory Gynecologic Surgery.
Mutter O, Taylor GA, Grebenyuk E, Kuo LE, Sanserino KA
J Minim Invasive Gynecol 2021 May;28(5):1033-1040.e1. Epub 2021 Jan 8 doi: 10.1016/j.jmig.2021.01.001. PMID: 33429058
Accelerating availability of clinically-relevant parameter estimates from thromboelastogram point-of-care device.
Pressly MA, Parker RS, Neal MD, Sperry JL, Clermont G
J Trauma Acute Care Surg 2020 May;88(5):654-660. doi: 10.1097/TA.0000000000002608. PMID: 32032282Free PMC Article
Bleeding issues in neonates and infants - update 2015.
Nowak-Göttl U, Limperger V, Bauer A, Kowalski D, Kenet G
Thromb Res 2015 Feb;135 Suppl 1:S41-3. Epub 2015 Feb 9 doi: 10.1016/S0049-3848(15)50440-4. PMID: 25903533

Prognosis

Screening of subclinical functional hemoglobin and red blood cell abnormalities among blood donors of Fayoum University Hospital in Egypt: Are RET-He, and IRF useful screening tools?
Bakr S, Yousief E, Ezzat EM, Elsary AY, Elamir AM, Gamal M
Transfus Apher Sci 2023 Oct;62(5):103781. Epub 2023 Jul 27 doi: 10.1016/j.transci.2023.103781. PMID: 37524581
Changes in peripheral blood cellular morphology as diagnostic markers for COVID-19 infection.
Gabr H, Bastawy S, Abdel Aal AA, Khalil NM, Fateen M
Int J Lab Hematol 2022 Jun;44(3):454-460. Epub 2022 Jan 19 doi: 10.1111/ijlh.13799. PMID: 35048518
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.
Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G
Clin Chem Lab Med 2020 Jun 25;58(7):1021-1028. doi: 10.1515/cclm-2020-0369. PMID: 32286245
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Clinical prediction guides

Changes in peripheral blood cellular morphology as diagnostic markers for COVID-19 infection.
Gabr H, Bastawy S, Abdel Aal AA, Khalil NM, Fateen M
Int J Lab Hematol 2022 Jun;44(3):454-460. Epub 2022 Jan 19 doi: 10.1111/ijlh.13799. PMID: 35048518
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.
Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G
Clin Chem Lab Med 2020 Jun 25;58(7):1021-1028. doi: 10.1515/cclm-2020-0369. PMID: 32286245
Next-generation reference intervals for pediatric hematology.
Zierk J, Hirschmann J, Toddenroth D, Arzideh F, Haeckel R, Bertram A, Cario H, Frühwald MC, Groß HJ, Groening A, Grützner S, Gscheidmeier T, Hoff T, Hoffmann R, Klauke R, Krebs A, Lichtinghagen R, Mühlenbrock-Lenter S, Neumann M, Nöllke P, Niemeyer CM, Razum O, Ruf HG, Steigerwald U, Streichert T, Torge A, Rascher W, Prokosch HU, Rauh M, Metzler M
Clin Chem Lab Med 2019 Sep 25;57(10):1595-1607. doi: 10.1515/cclm-2018-1236. PMID: 31005947
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Recent systematic reviews

Routine preoperative testing: a systematic review of the evidence.
Munro J, Booth A, Nicholl J
Health Technol Assess 1997;1(12):i-iv; 1-62. PMID: 9483155

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