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Focal emotional seizure

MedGen UID:
601863
•Concept ID:
C0422861
•
Disease or Syndrome
Synonym: Affective seizure
SNOMED CT: Focal onset emotional seizure (1285078002); Focal onset emotional epileptic seizure (1285078002); Focal-onset emotional epileptic seizure (1285078002); Focal emotional seizure (1285078002)
 
HPO: HP:0025613

Definition

Seizures presenting with an emotion or the appearance of having an emotion as an early prominent feature, such as fear, spontaneous joy or euphoria, laughing (gelastic), or crying, (dacrystic). These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer. [from HPO]

Professional guidelines

PubMed

Treatment of Comorbid Anxiety and Epilepsy.
Salpekar JA, Ma GJ, Mietchen J, Mani J, Jones JE
J Neuropsychiatry Clin Neurosci 2023 Summer;35(3):218-227. Epub 2023 Feb 14 doi: 10.1176/appi.neuropsych.20220116. PMID: 36785943
Contemporary surgical management of drug-resistant focal epilepsy.
Milovanović JR, Janković SM, Milovanović D, Ružić Zečević D, Folić M, Kostić M, Ranković G, Stefanović S
Expert Rev Neurother 2020 Jan;20(1):23-40. Epub 2019 Oct 23 doi: 10.1080/14737175.2020.1676733. PMID: 31583915
Epilepsy treatment in adults and adolescents: Expert opinion, 2016.
Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD
Epilepsy Behav 2017 Apr;69:186-222. Epub 2017 Feb 23 doi: 10.1016/j.yebeh.2016.11.018. PMID: 28237319

Recent clinical studies

Etiology

Ictal semiology of gelastic seizures.
Mirandola L, Cantalupo G, d'Orsi G, Meletti S, Vaudano AE, Di Vito L, Vignoli A, Tassi L, Pelliccia V
Epilepsy Behav 2023 Mar;140:109025. Epub 2023 Feb 11 doi: 10.1016/j.yebeh.2022.109025. PMID: 36780776
Clinical research challenges posed by difficult-to-treat depression.
Rush AJ, Sackeim HA, Conway CR, Bunker MT, Hollon SD, Demyttenaere K, Young AH, Aaronson ST, Dibué M, Thase ME, McAllister-Williams RH
Psychol Med 2022 Feb;52(3):419-432. Epub 2022 Jan 7 doi: 10.1017/S0033291721004943. PMID: 34991768Free PMC Article
Antidepressants for people with epilepsy and depression.
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy.
Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group
Epilepsia 2010 May;51(5):899-908. Epub 2010 Mar 17 doi: 10.1111/j.1528-1167.2010.02536.x. PMID: 20331461
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717

Diagnosis

CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Frontal lobe seizures: overview and update.
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Endogenous opiates and behavior: 2017.
Bodnar RJ
Peptides 2020 Feb;124:170223. Epub 2019 Dec 2 doi: 10.1016/j.peptides.2019.170223. PMID: 31805297
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.
Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
Epilepsia 2017 Apr;58(4):522-530. Epub 2017 Mar 8 doi: 10.1111/epi.13670. PMID: 28276060
Musicogenic epilepsy.
Stern J
Handb Clin Neurol 2015;129:469-77. doi: 10.1016/B978-0-444-62630-1.00026-3. PMID: 25726285

Therapy

Ictal semiology of gelastic seizures.
Mirandola L, Cantalupo G, d'Orsi G, Meletti S, Vaudano AE, Di Vito L, Vignoli A, Tassi L, Pelliccia V
Epilepsy Behav 2023 Mar;140:109025. Epub 2023 Feb 11 doi: 10.1016/j.yebeh.2022.109025. PMID: 36780776
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Antidepressants for people with epilepsy and depression.
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Musicogenic epilepsy.
Stern J
Handb Clin Neurol 2015;129:469-77. doi: 10.1016/B978-0-444-62630-1.00026-3. PMID: 25726285
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy.
Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group
Epilepsia 2010 May;51(5):899-908. Epub 2010 Mar 17 doi: 10.1111/j.1528-1167.2010.02536.x. PMID: 20331461

Prognosis

Ecstatic or Mystical Experience through Epilepsy.
Picard F
J Cogn Neurosci 2023 Sep 1;35(9):1372-1381. doi: 10.1162/jocn_a_02031. PMID: 37432752Free PMC Article
CASPR2-IgG-associated autoimmune seizures.
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Frontal lobe seizures: overview and update.
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy.
Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group
Epilepsia 2010 May;51(5):899-908. Epub 2010 Mar 17 doi: 10.1111/j.1528-1167.2010.02536.x. PMID: 20331461
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717

Clinical prediction guides

Ictal semiology of gelastic seizures.
Mirandola L, Cantalupo G, d'Orsi G, Meletti S, Vaudano AE, Di Vito L, Vignoli A, Tassi L, Pelliccia V
Epilepsy Behav 2023 Mar;140:109025. Epub 2023 Feb 11 doi: 10.1016/j.yebeh.2022.109025. PMID: 36780776
Nano-Hydrogel for the Treatment of Depression and Epilepsy.
Yang L
J Biomed Nanotechnol 2022 Apr 1;18(4):1097-1105. doi: 10.1166/jbn.2022.3318. PMID: 35854439
Ictal fear during parietal seizures.
Yaşgüçlükal MA, Makhalova J, Carron R, Bartolomei F
Epileptic Disord 2021 Oct 1;23(5):793-798. doi: 10.1684/epd.2021.1321. PMID: 34588160
Antidepressants for people with epilepsy and depression.
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Musicogenic seizures.
Avanzini G
Ann N Y Acad Sci 2003 Nov;999:95-102. doi: 10.1196/annals.1284.008. PMID: 14681120

Recent systematic reviews

Exploring the association between epilepsy and depression: A systematic review and meta-analysis.
Qin SK, Yang ZX, Guan ZW, Zhang JH, Ping X, Lu Y, Pei L
PLoS One 2022;17(12):e0278907. Epub 2022 Dec 15 doi: 10.1371/journal.pone.0278907. PMID: 36520790Free PMC Article
Antidepressants for people with epilepsy and depression.
Maguire MJ, Marson AG, Nevitt SJ
Cochrane Database Syst Rev 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3. PMID: 33860531Free PMC Article
Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review.
Iurina E, Bailles E, Pintor L
Seizure 2021 Feb;85:95-101. Epub 2021 Jan 7 doi: 10.1016/j.seizure.2020.12.026. PMID: 33453594
Social cognition in temporal lobe epilepsy: A systematic review and meta-analysis.
Bora E, Meletti S
Epilepsy Behav 2016 Jul;60:50-57. Epub 2016 May 11 doi: 10.1016/j.yebeh.2016.04.024. PMID: 27179192
Theory of Mind in Patients with Epilepsy: a Systematic Review and Meta-analysis.
Stewart E, Catroppa C, Lah S
Neuropsychol Rev 2016 Mar;26(1):3-24. Epub 2016 Jan 21 doi: 10.1007/s11065-015-9313-x. PMID: 26797753

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