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Plantar fibromatosis

MedGen UID:
56385
Concept ID:
C0158360
Neoplastic Process
Synonyms: Ledderhose disease; Lederhose disease
SNOMED CT: Plantar fascial fibromatosis (13370002); Plantar fibromatosis (13370002); Ledderhose's disease (13370002); Dupuytren disease of foot (13370002)
 
Monarch Initiative: MONDO:0004684
Orphanet: ORPHA199251

Definition

A rare, benign, superficial fibromatosis disease characterized by single or multiple, uni- or bilateral, fixed, slow-growing, round, firm nodules typically located on the medial portion of the plantar aponeurosis, with no calcification. Patients are often asymptomatic or may present with foot pain, difficulty to walk or stand and, rarely, toe contractures. Histopathology reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology and no atypia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlantar fibromatosis
Follow this link to review classifications for Plantar fibromatosis in Orphanet.

Professional guidelines

PubMed

Flores DV, Goes PK, Damer A, Huang BK
Radiographics 2024 Apr;44(4):e230163. doi: 10.1148/rg.230163. PMID: 38512730
Fuiano M, Mosca M, Caravelli S, Massimi S, Benedetti MG, Di Caprio F, Mosca S, Zaffagnini S
Foot Ankle Surg 2019 Oct;25(5):559-564. Epub 2018 Jun 11 doi: 10.1016/j.fas.2018.06.001. PMID: 30321942
Schuster J, Saraiya S, Tennyson N, Nedelka M, Mukhopadhyay N, Weiss E
Pract Radiat Oncol 2015 Nov-Dec;5(6):e651-8. Epub 2015 Jul 2 doi: 10.1016/j.prro.2015.06.010. PMID: 26421835

Recent clinical studies

Etiology

de Haan A, van Nes JGH, Kolff MW, van der Toorn PP, Westenberg AH, van der Vegt AE, Groen H, Overbosch J, van der Laan HP, Werker PMN, Langendijk JA, Steenbakkers RJHM
Radiother Oncol 2023 Aug;185:109718. Epub 2023 May 20 doi: 10.1016/j.radonc.2023.109718. PMID: 37211283
Hsu CY, Ke DS, Lin CL, Kao CH
PLoS One 2021;16(11):e0259942. Epub 2021 Nov 24 doi: 10.1371/journal.pone.0259942. PMID: 34818359Free PMC Article
Ahmed M, Weinstein JL, Hussain J, Sarwar A, Anderson M, Dillon B
Cardiovasc Intervent Radiol 2018 Feb;41(2):298-304. Epub 2017 Oct 3 doi: 10.1007/s00270-017-1801-3. PMID: 28975378
Jeswani T, Morlese J, McNally EG
Clin Radiol 2009 Sep;64(9):931-9. Epub 2009 Jun 18 doi: 10.1016/j.crad.2009.02.020. PMID: 19664484
Robbin MR, Murphey MD, Temple HT, Kransdorf MJ, Choi JJ
Radiographics 2001 May-Jun;21(3):585-600. doi: 10.1148/radiographics.21.3.g01ma21585. PMID: 11353108

Diagnosis

Nduka JC, Lam K, Chandrasekar CR
Foot (Edinb) 2021 Dec;49:101736. Epub 2020 Sep 8 doi: 10.1016/j.foot.2020.101736. PMID: 33268229
Newman C, McQuaid SE
Ir Med J 2019 Apr 11;112(4):919. PMID: 31243948
Zgonis T, Jolly GP, Polyzois V, Kanuck DM, Stamatis ED
Clin Podiatr Med Surg 2005 Jan;22(1):11-8. doi: 10.1016/j.cpm.2004.08.002. PMID: 15555840
Robbin MR, Murphey MD, Temple HT, Kransdorf MJ, Choi JJ
Radiographics 2001 May-Jun;21(3):585-600. doi: 10.1148/radiographics.21.3.g01ma21585. PMID: 11353108
Paletta FX
Am Fam Physician 1981 May;23(5):85-90. PMID: 7234634

Therapy

de Haan A, van Nes JGH, Kolff MW, van der Toorn PP, Westenberg AH, van der Vegt AE, Groen H, Overbosch J, van der Laan HP, Werker PMN, Langendijk JA, Steenbakkers RJHM
Radiother Oncol 2023 Aug;185:109718. Epub 2023 May 20 doi: 10.1016/j.radonc.2023.109718. PMID: 37211283
Schoenfeld JD, Agaram NP, Lefkowitz RA, Kelly CM, Healey JH, Gounder MM
Oncologist 2022 Mar 11;27(3):e294-e296. doi: 10.1093/oncolo/oyab050. PMID: 35274715Free PMC Article
Vasconcellos LFR, Nassif D, Spitz M
Neurologist 2019 Sep;24(5):150-151. doi: 10.1097/NRL.0000000000000240. PMID: 31478998
Veith NT, Tschernig T, Histing T, Madry H
Foot Ankle Int 2013 Dec;34(12):1742-6. Epub 2013 Sep 16 doi: 10.1177/1071100713505535. PMID: 24043350
Knobloch K, Kuehn M, Vogt PM
Med Hypotheses 2011 May;76(5):635-7. Epub 2011 Feb 1 doi: 10.1016/j.mehy.2011.01.018. PMID: 21277691

Prognosis

de Haan A, Hijmans JM, van der Vegt AE, van der Laan HP, van Nes JGH, Werker PMN, Langendijk JA, Steenbakkers RJHM
Foot (Edinb) 2023 Sep;56:101990. Epub 2023 Mar 1 doi: 10.1016/j.foot.2023.101990. PMID: 36905795
Tay AYW, Tay KS, Thever Y, Hao Y, Yeo NEM
Foot Ankle Surg 2021 Jun;27(4):400-404. Epub 2020 May 27 doi: 10.1016/j.fas.2020.05.004. PMID: 32605767
Kelenjian S, Mattjie RA, Franz R, Biedermann T, Brockow K
J Dtsch Dermatol Ges 2019 Apr;17(4):393-397. Epub 2019 Mar 13 doi: 10.1111/ddg.13808. PMID: 30865379
Gudmundsson KG, Jónsson T, Arngrímsson R
Foot Ankle Int 2013 Jun;34(6):841-5. Epub 2013 Feb 5 doi: 10.1177/1071100713475352. PMID: 23386754
Sammarco GJ, Mangone PG
Foot Ankle Int 2000 Jul;21(7):563-9. doi: 10.1177/107110070002100706. PMID: 10919621

Clinical prediction guides

de Haan A, van Nes JGH, Kolff MW, van der Toorn PP, Westenberg AH, van der Vegt AE, Groen H, Overbosch J, van der Laan HP, Werker PMN, Langendijk JA, Steenbakkers RJHM
Radiother Oncol 2023 Aug;185:109718. Epub 2023 May 20 doi: 10.1016/j.radonc.2023.109718. PMID: 37211283
de Haan A, Hijmans JM, van der Vegt AE, van der Laan HP, van Nes JGH, Werker PMN, Langendijk JA, Steenbakkers RJHM
Foot (Edinb) 2023 Sep;56:101990. Epub 2023 Mar 1 doi: 10.1016/j.foot.2023.101990. PMID: 36905795
Tay AYW, Tay KS, Thever Y, Hao Y, Yeo NEM
Foot Ankle Surg 2021 Jun;27(4):400-404. Epub 2020 May 27 doi: 10.1016/j.fas.2020.05.004. PMID: 32605767
Ahmed M, Weinstein JL, Hussain J, Sarwar A, Anderson M, Dillon B
Cardiovasc Intervent Radiol 2018 Feb;41(2):298-304. Epub 2017 Oct 3 doi: 10.1007/s00270-017-1801-3. PMID: 28975378
Gudmundsson KG, Jónsson T, Arngrímsson R
Foot Ankle Int 2013 Jun;34(6):841-5. Epub 2013 Feb 5 doi: 10.1177/1071100713475352. PMID: 23386754

Recent systematic reviews

Anwander H, Weichsel F, Cullmann J, Seidel A, Hayoz A, Krause F
Foot Ankle Spec 2024 Apr;17(2):109-116. Epub 2021 Aug 8 doi: 10.1177/19386400211032099. PMID: 34369197
Fuiano M, Mosca M, Caravelli S, Massimi S, Benedetti MG, Di Caprio F, Mosca S, Zaffagnini S
Foot Ankle Surg 2019 Oct;25(5):559-564. Epub 2018 Jun 11 doi: 10.1016/j.fas.2018.06.001. PMID: 30321942
Espert M, Anderson MR, Baumhauer JF
Foot Ankle Int 2018 Jun;39(6):751-757. Epub 2018 Apr 5 doi: 10.1177/1071100718768051. PMID: 29619843
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394
Grenfell S, Borg M
J Med Imaging Radiat Oncol 2014 Oct;58(5):641-7. Epub 2014 Apr 14 doi: 10.1111/1754-9485.12178. PMID: 24730457

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