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Duodenal Adenoma

MedGen UID:
196648
•Concept ID:
C0743301
•
Disease or Syndrome

Definition

A circumscribed neoplasm that arises from the glandular epithelium of the duodenum. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. [from NCI]

Professional guidelines

PubMed

Prevalence and endoscopic treatment outcomes of upper gastrointestinal neoplasms in familial adenomatous polyposis.
Noh JH, Song EM, Ahn JY, Yang DH, Lee W, Hong J, Kim A, Na HK, Lee JH, Jung KW, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY
Surg Endosc 2022 Feb;36(2):1310-1319. Epub 2021 Mar 11 doi: 10.1007/s00464-021-08406-0. PMID: 33709227
Endoscopic management of superficial nonampullary duodenal tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Vanbiervliet G, Moss A, Arvanitakis M, Arnelo U, Beyna T, Busch O, Deprez PH, Kunovsky L, Larghi A, Manes G, Napoleon B, Nalankilli K, Nayar M, Pérez-Cuadrado-Robles E, Seewald S, Strijker M, Barthet M, van Hooft JE
Endoscopy 2021 May;53(5):522-534. Epub 2021 Apr 1 doi: 10.1055/a-1442-2395. PMID: 33822331
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article

Recent clinical studies

Etiology

Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma.
Nortunen M, Parkkila S, Saarnio J, Huhta H, Karttunen TJ
J Histochem Cytochem 2021 Nov;69(11):677-690. Epub 2021 Oct 12 doi: 10.1369/00221554211050133. PMID: 34636283Free PMC Article
Endoscopic Treatment for Superficial Nonampullary Duodenal Tumors.
Yang HJ
Korean J Gastroenterol 2021 Apr 25;77(4):164-170. doi: 10.4166/kjg.2021.039. PMID: 33896904
Current Challenge: Endoscopic Submucosal Dissection of Superficial Non-ampullary Duodenal Epithelial Tumors.
Akahoshi K, Kubokawa M, Inamura K, Akahoshi K, Shiratsuchi Y, Tamura S
Curr Treat Options Oncol 2020 Oct 26;21(12):98. doi: 10.1007/s11864-020-00796-y. PMID: 33104938Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Duodenal ESD: conquering difficulties.
Yamamoto H, Miura Y
Gastrointest Endosc Clin N Am 2014 Apr;24(2):235-44. doi: 10.1016/j.giec.2013.11.007. PMID: 24679234

Diagnosis

Endoscopic Treatment for Superficial Nonampullary Duodenal Tumors.
Yang HJ
Korean J Gastroenterol 2021 Apr 25;77(4):164-170. doi: 10.4166/kjg.2021.039. PMID: 33896904
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article
Treatment for superficial non-ampullary duodenal epithelial tumors.
Kakushima N, Kanemoto H, Tanaka M, Takizawa K, Ono H
World J Gastroenterol 2014 Sep 21;20(35):12501-8. doi: 10.3748/wjg.v20.i35.12501. PMID: 25253950Free PMC Article
Advances in diagnostic endoscopy for duodenal, including ampullary, adenoma.
Pittayanon R, Imraporn B, Rerknimitr R, Kullavanijaya P
Dig Endosc 2014 Apr;26 Suppl 2:10-5. doi: 10.1111/den.12244. PMID: 24750142

Therapy

The conundrum in endoscopic management of duodenal polyps: a tertiary cancer center experience.
Lee JH, Yu AC, Ali FS, Ahmed O, Lynch P, Ge P, Coronel E, Kim M, Coronel M, Folloder J, Katz MHG
Expert Rev Gastroenterol Hepatol 2022 Jun;16(6):569-576. Epub 2022 Jun 16 doi: 10.1080/17474124.2022.2088508. PMID: 35687675
Nonampullary Duodenal Adenomas Rarely Recur after Complete Endoscopic Resection: A Swiss Experience Including a Literature Review.
Valli PV, Mertens JC, Sonnenberg A, Bauerfeind P
Digestion 2017;96(3):149-157. Epub 2017 Aug 31 doi: 10.1159/000479625. PMID: 28854423
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article
Endoscopic management of mucosal lesions in the gastrointestinal tract.
Chen WC, Wallace MB
Expert Rev Gastroenterol Hepatol 2016;10(4):481-95. Epub 2015 Dec 11 doi: 10.1586/17474124.2016.1122520. PMID: 26581857
Treatment for superficial non-ampullary duodenal epithelial tumors.
Kakushima N, Kanemoto H, Tanaka M, Takizawa K, Ono H
World J Gastroenterol 2014 Sep 21;20(35):12501-8. doi: 10.3748/wjg.v20.i35.12501. PMID: 25253950Free PMC Article

Prognosis

Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma.
Nortunen M, Parkkila S, Saarnio J, Huhta H, Karttunen TJ
J Histochem Cytochem 2021 Nov;69(11):677-690. Epub 2021 Oct 12 doi: 10.1369/00221554211050133. PMID: 34636283Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Nonampullary Duodenal Adenomas Rarely Recur after Complete Endoscopic Resection: A Swiss Experience Including a Literature Review.
Valli PV, Mertens JC, Sonnenberg A, Bauerfeind P
Digestion 2017;96(3):149-157. Epub 2017 Aug 31 doi: 10.1159/000479625. PMID: 28854423
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article
Preoperative endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors, including magnifying endoscopy.
Tsuji S, Doyama H, Tsuji K, Tsuyama S, Tominaga K, Yoshida N, Takemura K, Yamada S, Niwa H, Katayanagi K, Kurumaya H, Okada T
World J Gastroenterol 2015 Nov 7;21(41):11832-41. doi: 10.3748/wjg.v21.i41.11832. PMID: 26557007Free PMC Article

Clinical prediction guides

Clinical characteristics and course of sporadic non-ampullary duodenal adenomas: A multicenter retrospective study.
Kanzaki H, Matsueda K, Nakagawa M, Inaba T, Takatani M, Takenaka R, Yoshioka M, Imagawa A, Inoue M, Suzuki S, Tomoda J, Iwamuro M, Kawano S, Kawahara Y, Tanaka T, Okada H
Medicine (Baltimore) 2021 Oct 1;100(39):e27382. doi: 10.1097/MD.0000000000027382. PMID: 34596158Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M
Surg Today 2018 Aug;48(8):765-772. Epub 2018 Mar 10 doi: 10.1007/s00595-018-1649-4. PMID: 29525853
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article
Preoperative endoscopic diagnosis of superficial non-ampullary duodenal epithelial tumors, including magnifying endoscopy.
Tsuji S, Doyama H, Tsuji K, Tsuyama S, Tominaga K, Yoshida N, Takemura K, Yamada S, Niwa H, Katayanagi K, Kurumaya H, Okada T
World J Gastroenterol 2015 Nov 7;21(41):11832-41. doi: 10.3748/wjg.v21.i41.11832. PMID: 26557007Free PMC Article

Recent systematic reviews

Upper GI involvement in children with familial adenomatous polyposis syndrome: single-center experience and meta-analysis of the literature.
Gutierrez Sanchez LH, Alsawas M, Stephens M, Murad MH, Absah I
Gastrointest Endosc 2018 Mar;87(3):648-656.e3. Epub 2017 Nov 6 doi: 10.1016/j.gie.2017.10.043. PMID: 29122597

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