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Sputum eosinophilia

MedGen UID:
537039
•Concept ID:
C0241234
•
Finding
Synonym: Sputum: eosinophilia
SNOMED CT: Sputum: eosinophilia (167997000)
 
HPO: HP:0032017

Definition

An increased proportion of eosinophils in sputum in the differentiated cell count. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSputum eosinophilia

Professional guidelines

PubMed

Biomarkers and asthma management: an update.
Bayes HK, Cowan DC
Curr Opin Allergy Clin Immunol 2016 Jun;16(3):210-7. doi: 10.1097/ACI.0000000000000263. PMID: 27057795
Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma.
Hilvering B, Xue L, Pavord ID
Ther Adv Respir Dis 2015 Aug;9(4):135-45. Epub 2015 Apr 21 doi: 10.1177/1753465815581279. PMID: 25900924
Eosinophilic bronchitis: clinical features, management and pathogenesis.
Birring SS, Berry M, Brightling CE, Pavord ID
Am J Respir Med 2003;2(2):169-73. doi: 10.1007/BF03256647. PMID: 14720015

Recent clinical studies

Etiology

Biomarkers in asthma, potential for therapeutic intervention.
Pasha MA, Hopp RJ, Habib N, Tang DD
J Asthma 2024 Nov;61(11):1376-1391. Epub 2024 Jun 13 doi: 10.1080/02770903.2024.2361783. PMID: 38805392
Managing the safety of inhaled corticosteroids in COPD and the risk of pneumonia.
Liapikou A, Toumbis M, Torres A
Expert Opin Drug Saf 2015 Aug;14(8):1237-47. Epub 2015 Jun 25 doi: 10.1517/14740338.2015.1057494. PMID: 26113207
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942
Aspergillosis and atopy in cystic fibrosis.
Nelson LA, Callerame ML, Schwartz RH
Am Rev Respir Dis 1979 Oct;120(4):863-73. doi: 10.1164/arrd.1979.120.4.863. PMID: 507513
Asthma in the elderly.
Lee HY, Stretton TB
Br Med J 1972 Oct 14;4(5832):93-5. doi: 10.1136/bmj.4.5832.93. PMID: 5077475Free PMC Article

Diagnosis

Biomarkers in asthma, potential for therapeutic intervention.
Pasha MA, Hopp RJ, Habib N, Tang DD
J Asthma 2024 Nov;61(11):1376-1391. Epub 2024 Jun 13 doi: 10.1080/02770903.2024.2361783. PMID: 38805392
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Eosinophilic bronchitis: an important cause of prolonged cough.
Brightling CE, Pavord ID
Ann Med 2000 Oct;32(7):446-51. doi: 10.3109/07853890009002019. PMID: 11087164
Aspergillosis and atopy in cystic fibrosis.
Nelson LA, Callerame ML, Schwartz RH
Am Rev Respir Dis 1979 Oct;120(4):863-73. doi: 10.1164/arrd.1979.120.4.863. PMID: 507513
Asthma in the elderly.
Lee HY, Stretton TB
Br Med J 1972 Oct 14;4(5832):93-5. doi: 10.1136/bmj.4.5832.93. PMID: 5077475Free PMC Article

Therapy

Biomarkers in asthma, potential for therapeutic intervention.
Pasha MA, Hopp RJ, Habib N, Tang DD
J Asthma 2024 Nov;61(11):1376-1391. Epub 2024 Jun 13 doi: 10.1080/02770903.2024.2361783. PMID: 38805392
Triple inhaled therapy for chronic obstructive pulmonary disease.
Montuschi P, Malerba M, Macis G, Mores N, Santini G
Drug Discov Today 2016 Nov;21(11):1820-1827. Epub 2016 Jul 21 doi: 10.1016/j.drudis.2016.07.009. PMID: 27452453
Managing the safety of inhaled corticosteroids in COPD and the risk of pneumonia.
Liapikou A, Toumbis M, Torres A
Expert Opin Drug Saf 2015 Aug;14(8):1237-47. Epub 2015 Jun 25 doi: 10.1517/14740338.2015.1057494. PMID: 26113207
Categorizing asthma severity and monitoring control of chronic asthma.
Colice GL
Curr Opin Pulm Med 2002 Jan;8(1):4-8. doi: 10.1097/00063198-200201000-00002. PMID: 11753117
Asthma in the elderly.
Lee HY, Stretton TB
Br Med J 1972 Oct 14;4(5832):93-5. doi: 10.1136/bmj.4.5832.93. PMID: 5077475Free PMC Article

Prognosis

Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Phenotyping patients with chronic cough: Evaluating the ability to predict the response to anti-inflammatory therapy.
Sadeghi MH, Wright CE, Hart S, Crooks M, Morice A
Ann Allergy Asthma Immunol 2018 Mar;120(3):285-291. doi: 10.1016/j.anai.2017.12.004. PMID: 29508715
Point-of-care blood eosinophil count in a severe asthma clinic setting.
Heffler E, Terranova G, Chessari C, Frazzetto V, Crimi C, Fichera S, Picardi G, Nicolosi G, Porto M, Intravaia R, Crimi N
Ann Allergy Asthma Immunol 2017 Jul;119(1):16-20. doi: 10.1016/j.anai.2017.05.016. PMID: 28668237
Inflammatory markers as exacerbation risk factors after asthma therapy switch from inhaled steroids to montelukast.
Ciółkowski J, Mazurek H, Hydzik P, Stasiowska B
Pulm Pharmacol Ther 2016 Aug;39:7-13. Epub 2016 May 24 doi: 10.1016/j.pupt.2016.05.002. PMID: 27234706
Aspergillosis and atopy in cystic fibrosis.
Nelson LA, Callerame ML, Schwartz RH
Am Rev Respir Dis 1979 Oct;120(4):863-73. doi: 10.1164/arrd.1979.120.4.863. PMID: 507513

Clinical prediction guides

Phenotyping patients with chronic cough: Evaluating the ability to predict the response to anti-inflammatory therapy.
Sadeghi MH, Wright CE, Hart S, Crooks M, Morice A
Ann Allergy Asthma Immunol 2018 Mar;120(3):285-291. doi: 10.1016/j.anai.2017.12.004. PMID: 29508715
Inflammatory markers as exacerbation risk factors after asthma therapy switch from inhaled steroids to montelukast.
Ciółkowski J, Mazurek H, Hydzik P, Stasiowska B
Pulm Pharmacol Ther 2016 Aug;39:7-13. Epub 2016 May 24 doi: 10.1016/j.pupt.2016.05.002. PMID: 27234706
Can Sputum Eosinophilia Be a Constant Feature in Severe Refractory Asthmatics? A 3-Year Longitudinal Study.
Dente FL, Latorre M, Novelli F, Cianchetti S, Bartoli ML, Bacci E, Di Franco A, Vagaggini B, Celi A, Paggiaro P
Int Arch Allergy Immunol 2015;166(4):287-90. Epub 2015 May 9 doi: 10.1159/000381853. PMID: 25968565
Role of PGE2 in asthma and nonasthmatic eosinophilic bronchitis.
Sastre B, del Pozo V
Mediators Inflamm 2012;2012:645383. Epub 2012 Mar 19 doi: 10.1155/2012/645383. PMID: 22529528Free PMC Article
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE
Am J Respir Crit Care Med 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC. PMID: 21680942

Recent systematic reviews

Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults.
Petsky HL, Li A, Chang AB
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD005603. doi: 10.1002/14651858.CD005603.pub3. PMID: 28837221Free PMC Article
Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults.
Petsky HL, Kynaston JA, Turner C, Li AM, Cates CJ, Lasserson TJ, Chang AB
Cochrane Database Syst Rev 2007 Apr 18;(2):CD005603. doi: 10.1002/14651858.CD005603.pub2. PMID: 17443604

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