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Abnormal sputum

MedGen UID:
510701
•Concept ID:
C0159054
•
Finding
Synonyms: Abnormal sputum morphology; Sputum examination: abnormal
SNOMED CT: Sputum examination: abnormal (167986000); Abnormal sputum (274708000)
 
HPO: HP:0032016

Definition

Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin. [from HPO]

Professional guidelines

PubMed

Acute lower respiratory tract infections: Symptoms, findings and management in Danish general practice.
Hansen LS, Lykkegaard J, Thomsen JL, Hansen MP
Eur J Gen Pract 2020 Dec;26(1):14-20. Epub 2019 Oct 25 doi: 10.1080/13814788.2019.1674279. PMID: 31650886Free PMC Article
Impact of chest CT on the clinical management of immunocompetent emergency department patients with chest radiographic findings of pneumonia.
Banker PD, Jain VR, Haramati LB
Emerg Radiol 2007 Nov;14(6):383-8. Epub 2007 Aug 15 doi: 10.1007/s10140-007-0659-0. PMID: 17701235
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

Recent clinical studies

Etiology

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Dornase alfa during lower respiratory tract infection post-lung transplantation: a randomized controlled trial.
Tarrant BJ, Snell G, Ivulich S, Button B, Thompson B, Holland A
Transpl Int 2019 Jun;32(6):603-613. Epub 2019 Feb 4 doi: 10.1111/tri.13400. PMID: 30632208
Automatic versus human reading of chest X-rays in the Zambia National Tuberculosis Prevalence Survey.
Melendez J, Philipsen RHHM, Chanda-Kapata P, Sunkutu V, Kapata N, van Ginneken B
Int J Tuberc Lung Dis 2017 Aug 1;21(8):880-886. doi: 10.5588/ijtld.16.0851. PMID: 28786796
Early detection of central airway lung cancer in smokers with silicosis.
Lo AI, Huang Y, Lam SY, Cheung AH, Au R, Leung CC, Lam WK, Ip MS, Chan-Yeung M, Lam B
Int J Tuberc Lung Dis 2011 Apr;15(4):523-7. doi: 10.5588/ijtld.10.0461. PMID: 21396213
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

Diagnosis

Tuberculosis case finding using population-based disease surveillance platforms in urban and rural Kenya.
Bigogo G, Cain K, Nyole D, Masyongo G, Auko JA, Wamola N, Okumu A, Agaya J, Montgomery J, Borgdorff M, Burton D
BMC Infect Dis 2018 Jun 7;18(1):262. doi: 10.1186/s12879-018-3172-z. PMID: 29879917Free PMC Article
Automatic versus human reading of chest X-rays in the Zambia National Tuberculosis Prevalence Survey.
Melendez J, Philipsen RHHM, Chanda-Kapata P, Sunkutu V, Kapata N, van Ginneken B
Int J Tuberc Lung Dis 2017 Aug 1;21(8):880-886. doi: 10.5588/ijtld.16.0851. PMID: 28786796
Early detection of central airway lung cancer in smokers with silicosis.
Lo AI, Huang Y, Lam SY, Cheung AH, Au R, Leung CC, Lam WK, Ip MS, Chan-Yeung M, Lam B
Int J Tuberc Lung Dis 2011 Apr;15(4):523-7. doi: 10.5588/ijtld.10.0461. PMID: 21396213
Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern.
Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush A
Pediatr Pulmonol 2005 Apr;39(4):318-24. doi: 10.1002/ppul.20159. PMID: 15678506
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

Therapy

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Dornase alfa during lower respiratory tract infection post-lung transplantation: a randomized controlled trial.
Tarrant BJ, Snell G, Ivulich S, Button B, Thompson B, Holland A
Transpl Int 2019 Jun;32(6):603-613. Epub 2019 Feb 4 doi: 10.1111/tri.13400. PMID: 30632208
Early detection of central airway lung cancer in smokers with silicosis.
Lo AI, Huang Y, Lam SY, Cheung AH, Au R, Leung CC, Lam WK, Ip MS, Chan-Yeung M, Lam B
Int J Tuberc Lung Dis 2011 Apr;15(4):523-7. doi: 10.5588/ijtld.10.0461. PMID: 21396213
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294
Clinical aspects of mucus and mucous plugging in asthma.
Fanta CH
J Asthma 1985;22(6):295-301. doi: 10.3109/02770908509087113. PMID: 3908443

Prognosis

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis.
Bush A, Payne D, Pike S, Jenkins G, Henke MO, Rubin BK
Chest 2006 Jan;129(1):118-23. doi: 10.1378/chest.129.1.118. PMID: 16424421
Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern.
Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush A
Pediatr Pulmonol 2005 Apr;39(4):318-24. doi: 10.1002/ppul.20159. PMID: 15678506
Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study.
Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA Jr, Kennedy TC
J Natl Cancer Inst 2001 Sep 19;93(18):1385-91. doi: 10.1093/jnci/93.18.1385. PMID: 11562389
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

Clinical prediction guides

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Narrow band imaging with high-resolution bronchovideoscopy: a new approach for visualizing angiogenesis in squamous cell carcinoma of the lung.
Shibuya K, Nakajima T, Fujiwara T, Chiyo M, Hoshino H, Moriya Y, Suzuki M, Hiroshima K, Nakatani Y, Yoshino I
Lung Cancer 2010 Aug;69(2):194-202. Epub 2010 Jun 11 doi: 10.1016/j.lungcan.2010.04.023. PMID: 20541831
High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia.
Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA Jr, Miller YE
Lung Cancer 2005 Aug;49(2):187-91. Epub 2005 Apr 14 doi: 10.1016/j.lungcan.2005.02.009. PMID: 16022912
Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern.
Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush A
Pediatr Pulmonol 2005 Apr;39(4):318-24. doi: 10.1002/ppul.20159. PMID: 15678506
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

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