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Abnormal sputum

MedGen UID:
510701
•Concept ID:
C0159054
•
Finding
Synonyms: Abnormal sputum morphology; Sputum examination: abnormal
SNOMED CT: Sputum examination: abnormal (167986000); Abnormal sputum (274708000)
 
HPO: HP:0032016

Definition

Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin. [from HPO]

Professional guidelines

PubMed

Acute lower respiratory tract infections: Symptoms, findings and management in Danish general practice.
Hansen LS, Lykkegaard J, Thomsen JL, Hansen MP
Eur J Gen Pract 2020 Dec;26(1):14-20. Epub 2019 Oct 25 doi: 10.1080/13814788.2019.1674279. PMID: 31650886Free PMC Article
Impact of chest CT on the clinical management of immunocompetent emergency department patients with chest radiographic findings of pneumonia.
Banker PD, Jain VR, Haramati LB
Emerg Radiol 2007 Nov;14(6):383-8. Epub 2007 Aug 15 doi: 10.1007/s10140-007-0659-0. PMID: 17701235
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

Recent clinical studies

Etiology

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Research in progress--LungSEARCH: a randomised controlled trial of surveillance for the early detection of lung cancer in a high-risk group.
Spiro SG, Hackshaw A; LungSEARCH Collaborative Group
Thorax 2016 Jan;71(1):91-3. Epub 2015 Jul 2 doi: 10.1136/thoraxjnl-2015-207433. PMID: 26138736Free PMC Article
Duration of anaesthesia, type of surgery, respiratory co-morbidity, predicted VO2max and smoking predict postoperative pulmonary complications after upper abdominal surgery: an observational study.
Scholes RL, Browning L, Sztendur EM, Denehy L
Aust J Physiother 2009;55(3):191-8. doi: 10.1016/s0004-9514(09)70081-9. PMID: 19681741
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294
Roentgenographically occult lung cancer. A ten-year experience.
Cortese DA, Pairolero PC, Bergstralh EJ, Woolner LB, Uhlenhopp MA, Piehler JM, Sanderson DR, Bernatz PE, Williams DE, Taylor WF, Payne WS, Fontana RS
J Thorac Cardiovasc Surg 1983 Sep;86(3):373-80. PMID: 6350725

Diagnosis

Research in progress--LungSEARCH: a randomised controlled trial of surveillance for the early detection of lung cancer in a high-risk group.
Spiro SG, Hackshaw A; LungSEARCH Collaborative Group
Thorax 2016 Jan;71(1):91-3. Epub 2015 Jul 2 doi: 10.1136/thoraxjnl-2015-207433. PMID: 26138736Free PMC Article
Duration of anaesthesia, type of surgery, respiratory co-morbidity, predicted VO2max and smoking predict postoperative pulmonary complications after upper abdominal surgery: an observational study.
Scholes RL, Browning L, Sztendur EM, Denehy L
Aust J Physiother 2009;55(3):191-8. doi: 10.1016/s0004-9514(09)70081-9. PMID: 19681741
A case of early-stage lung cancer detected by autofluorescence bronchoscopy.
Hanibuchi M, Yano S, Edakuni N, Inayama M, Sone S
J Med Invest 2004 Aug;51(3-4):234-7. doi: 10.2152/jmi.51.234. PMID: 15460912
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294
Roentgenographically occult lung cancer. A ten-year experience.
Cortese DA, Pairolero PC, Bergstralh EJ, Woolner LB, Uhlenhopp MA, Piehler JM, Sanderson DR, Bernatz PE, Williams DE, Taylor WF, Payne WS, Fontana RS
J Thorac Cardiovasc Surg 1983 Sep;86(3):373-80. PMID: 6350725

Therapy

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Research in progress--LungSEARCH: a randomised controlled trial of surveillance for the early detection of lung cancer in a high-risk group.
Spiro SG, Hackshaw A; LungSEARCH Collaborative Group
Thorax 2016 Jan;71(1):91-3. Epub 2015 Jul 2 doi: 10.1136/thoraxjnl-2015-207433. PMID: 26138736Free PMC Article
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294
Roentgenographically occult lung cancer. A ten-year experience.
Cortese DA, Pairolero PC, Bergstralh EJ, Woolner LB, Uhlenhopp MA, Piehler JM, Sanderson DR, Bernatz PE, Williams DE, Taylor WF, Payne WS, Fontana RS
J Thorac Cardiovasc Surg 1983 Sep;86(3):373-80. PMID: 6350725
Abnormal sputum cytopathology during chemotherapy with bleomycin.
Bedrossian CW, Corey BJ
Acta Cytol 1978 Jul-Aug;22(4):202-7. PMID: 83065

Prognosis

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Duration of anaesthesia, type of surgery, respiratory co-morbidity, predicted VO2max and smoking predict postoperative pulmonary complications after upper abdominal surgery: an observational study.
Scholes RL, Browning L, Sztendur EM, Denehy L
Aust J Physiother 2009;55(3):191-8. doi: 10.1016/s0004-9514(09)70081-9. PMID: 19681741
Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern.
Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush A
Pediatr Pulmonol 2005 Apr;39(4):318-24. doi: 10.1002/ppul.20159. PMID: 15678506
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294
Roentgenographically occult lung cancer. A ten-year experience.
Cortese DA, Pairolero PC, Bergstralh EJ, Woolner LB, Uhlenhopp MA, Piehler JM, Sanderson DR, Bernatz PE, Williams DE, Taylor WF, Payne WS, Fontana RS
J Thorac Cardiovasc Surg 1983 Sep;86(3):373-80. PMID: 6350725

Clinical prediction guides

Comprehensive Care Management in Conjunction with Sputum Cytometry-Guided Pharmacotherapy in a Post-Discharge Clinic for Patients with COPD.
Ho TN, Wald J, Borhan S, Lauks S, Campbell A, Chaput C, Pierce M, Perkins J, Camera J, MacPherson A, Cox G, Raghavan N, Amer R, Nair P
COPD 2021 Aug;18(4):411-416. Epub 2021 Jul 5 doi: 10.1080/15412555.2021.1945022. PMID: 34223776
Narrow band imaging with high-resolution bronchovideoscopy: a new approach for visualizing angiogenesis in squamous cell carcinoma of the lung.
Shibuya K, Nakajima T, Fujiwara T, Chiyo M, Hoshino H, Moriya Y, Suzuki M, Hiroshima K, Nakatani Y, Yoshino I
Lung Cancer 2010 Aug;69(2):194-202. Epub 2010 Jun 11 doi: 10.1016/j.lungcan.2010.04.023. PMID: 20541831
High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia.
Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA Jr, Miller YE
Lung Cancer 2005 Aug;49(2):187-91. Epub 2005 Apr 14 doi: 10.1016/j.lungcan.2005.02.009. PMID: 16022912
Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern.
Lex C, Payne DN, Zacharasiewicz A, Li AM, Wilson NM, Hansel TT, Bush A
Pediatr Pulmonol 2005 Apr;39(4):318-24. doi: 10.1002/ppul.20159. PMID: 15678506
Diagnosis and treatment of pneumonia in the surgical intensive care unit.
Burchard K
Surg Gynecol Obstet 1990;171 Suppl:35-40. PMID: 2244294

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