U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

MedGen UID:
459421
•Concept ID:
C2987195
•
Neoplastic Process

Definition

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form thin-branching papillae and exhibit high grade dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

Recent clinical studies

Etiology

Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y
Pancreatology 2021 Jun;21(4):755-762. Epub 2021 Feb 18 doi: 10.1016/j.pan.2021.02.012. PMID: 33632666
Metachronous intraductal papillary mucinous neoplasms disseminate via the pancreatic duct following resection.
Nagai K, Mizukami Y, Omori Y, Kin T, Yane K, Takahashi K, Ono Y, Sugitani A, Karasaki H, Shinohara T, Furukawa T, Hayashi T, Okumura T, Maguchi H, Katanuma A
Mod Pathol 2020 May;33(5):971-980. Epub 2019 Nov 13 doi: 10.1038/s41379-019-0405-7. PMID: 31723240
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948
Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas.
Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M
Gut 2011 Apr;60(4):509-16. Epub 2010 Dec 30 doi: 10.1136/gut.2010.210567. PMID: 21193453

Diagnosis

Intra-ampullary Papillary Tubular Neoplasm (IAPN): Clinicopathologic Analysis of 72 Cases Highlights the Distinctive Characteristics of a Poorly Recognized Entity.
Tarcan ZC, Esmer R, Akar KE, Bagci P, Bozkurtlar E, Saka B, Armutlu A, Sahin Ozkan H, Ozcan K, Taskin OC, Kapran Y, Aydin Mericoz C, Balci S, Yilmaz S, Cengiz D, Gurses B, Alper E, Tellioglu G, Bozkurt E, Bilge O, Cheng JD, Basturk O, Adsay NV
Am J Surg Pathol 2024 Sep 1;48(9):1093-1107. Epub 2024 Jul 18 doi: 10.1097/PAS.0000000000002275. PMID: 38938087
Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct Entities.
Wang T, Askan G, Ozcan K, Rana S, Zehir A, Bhanot UK, Yantiss RK, Rao DS, Wahl SJ, Bagci P, Balci S, Balachandran V, Jarnagin WR, Adsay NV, Klimstra DS, Basturk O
Arch Pathol Lab Med 2023 Dec 1;147(12):1390-1401. doi: 10.5858/arpa.2022-0343-OA. PMID: 36821179
Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y
Pancreatology 2021 Jun;21(4):755-762. Epub 2021 Feb 18 doi: 10.1016/j.pan.2021.02.012. PMID: 33632666
Pancreatobiliary-type intraductal papillary mucinous neoplasm of the pancreas may have 2 subtypes with distinct clinicopathologic and genetic features.
Shimizu T, Akita M, Sofue K, Toyama H, Itoh T, Fukumoto T, Zen Y
Hum Pathol 2019 Sep;91:26-35. Epub 2019 Jun 6 doi: 10.1016/j.humpath.2019.05.010. PMID: 31175918
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pancreas: A network meta-analysis.
Qi X, Zhao X, Su J, Xu M, Zhang W, Sheng H, Li Z, Wang J
Eur J Intern Med 2015 Oct;26(8):652-7. Epub 2015 Aug 12 doi: 10.1016/j.ejim.2015.07.016. PMID: 26275457

Prognosis

Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y
Pancreatology 2021 Jun;21(4):755-762. Epub 2021 Feb 18 doi: 10.1016/j.pan.2021.02.012. PMID: 33632666
Metachronous intraductal papillary mucinous neoplasms disseminate via the pancreatic duct following resection.
Nagai K, Mizukami Y, Omori Y, Kin T, Yane K, Takahashi K, Ono Y, Sugitani A, Karasaki H, Shinohara T, Furukawa T, Hayashi T, Okumura T, Maguchi H, Katanuma A
Mod Pathol 2020 May;33(5):971-980. Epub 2019 Nov 13 doi: 10.1038/s41379-019-0405-7. PMID: 31723240
Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.
Chang XY, Wu Y, Li Y, Wang J, Chen J
Mol Med Rep 2018 Jun;17(6):8061-8068. Epub 2018 Apr 12 doi: 10.3892/mmr.2018.8875. PMID: 29658583Free PMC Article
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Clinical prediction guides

Indication for resection and possibility of observation for intraductal papillary mucinous neoplasm with high-risk stigmata.
Abe K, Kitago M, Masugi Y, Iwasaki E, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Sakamoto M, Kitagawa Y
Pancreatology 2021 Jun;21(4):755-762. Epub 2021 Feb 18 doi: 10.1016/j.pan.2021.02.012. PMID: 33632666
Hyalinized stroma is a characteristic feature of pancreatic intraductal oncocytic papillary neoplasm: An immunohistochemical study.
Hirabayashi K, Kawanishi A, Morimachi M, Yamada M, Takanashi Y, Hori S, Serizawa A, Saika T, Nakagohri T, Nakamura N
Ann Diagn Pathol 2020 Dec;49:151639. Epub 2020 Oct 8 doi: 10.1016/j.anndiagpath.2020.151639. PMID: 33069084
Biliary intraductal tubule-forming neoplasm: a whole exome sequencing study of MUC5AC-positive and -negative cases.
Akita M, Hong SM, Sung YN, Kim MJ, Ajiki T, Fukumoto T, Itoh T, Zen Y
Histopathology 2020 Jun;76(7):1005-1012. Epub 2020 May 15 doi: 10.1111/his.14103. PMID: 32181510
Metachronous intraductal papillary mucinous neoplasms disseminate via the pancreatic duct following resection.
Nagai K, Mizukami Y, Omori Y, Kin T, Yane K, Takahashi K, Ono Y, Sugitani A, Karasaki H, Shinohara T, Furukawa T, Hayashi T, Okumura T, Maguchi H, Katanuma A
Mod Pathol 2020 May;33(5):971-980. Epub 2019 Nov 13 doi: 10.1038/s41379-019-0405-7. PMID: 31723240
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Supplemental Content

Table of contents

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...