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Microvascular complications of diabetes, susceptibility to, 2(MVCD2)

MedGen UID:
436442
•Concept ID:
C2675471
•
Finding
Synonym: Microvascular complications of diabetes 2
 
Gene (location): EPO (7q22.1)
 
Monarch Initiative: MONDO:0012962
OMIM®: 612623

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the EPO gene. [from MONDO]

Professional guidelines

PubMed

Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment.
Gurung RL, FitzGerald LM, McComish BJ, Verma N, Burdon KP
J Diabetes Res 2020;2020:5016916. Epub 2020 Nov 12 doi: 10.1155/2020/5016916. PMID: 33274237Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies.
Bloom RD, Crutchlow MF
Clin J Am Soc Nephrol 2008 Mar;3 Suppl 2(Suppl 2):S38-48. doi: 10.2215/CJN.02650707. PMID: 18309002Free PMC Article

Recent clinical studies

Etiology

Association of metabolic syndrome and chronic kidney disease.
Scurt FG, Ganz MJ, Herzog C, Bose K, Mertens PR, Chatzikyrkou C
Obes Rev 2024 Jan;25(1):e13649. Epub 2023 Oct 2 doi: 10.1111/obr.13649. PMID: 37783465
Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Risk factors for type 2 diabetes mellitus.
Fletcher B, Gulanick M, Lamendola C
J Cardiovasc Nurs 2002 Jan;16(2):17-23. doi: 10.1097/00005082-200201000-00003. PMID: 11800065

Diagnosis

Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta-analysis.
Yin F, Liu J, Fan MX, Zhou XL, Zhang XL
Nephrology (Carlton) 2018 Feb;23(2):107-116. doi: 10.1111/nep.13111. PMID: 28703918
Association of prediabetes-associated single nucleotide polymorphisms with microalbuminuria.
Choi JW, Moon S, Jang EJ, Lee CH, Park JS
PLoS One 2017;12(2):e0171367. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0171367. PMID: 28158221Free PMC Article
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article
Tropical chronic pancreatitis.
Barman KK, Premalatha G, Mohan V
Postgrad Med J 2003 Nov;79(937):606-15. doi: 10.1136/pmj.79.937.606. PMID: 14654569Free PMC Article

Therapy

Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Diabetes as a risk factor for medication-related osteonecrosis of the jaw.
Peer A, Khamaisi M
J Dent Res 2015 Feb;94(2):252-60. Epub 2014 Dec 4 doi: 10.1177/0022034514560768. PMID: 25477311Free PMC Article
Haptoglobin: basic and clinical aspects.
Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H
Antioxid Redox Signal 2010 Feb;12(2):293-304. doi: 10.1089/ars.2009.2793. PMID: 19659435
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Prognosis

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.
Hsieh AR, Huang YC, Yang YF, Lin HJ, Lin JM, Chang YW, Wu CM, Liao WL, Tsai FJ
BMJ Open Diabetes Res Care 2020 Jan;8(1) doi: 10.1136/bmjdrc-2019-000727. PMID: 31958309Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Tropical chronic pancreatitis.
Barman KK, Premalatha G, Mohan V
Postgrad Med J 2003 Nov;79(937):606-15. doi: 10.1136/pmj.79.937.606. PMID: 14654569Free PMC Article

Clinical prediction guides

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Effects of intensive insulin therapy on the retinal microvasculature in patients with type 2 diabetes mellitus: a prospective observational study.
Yang N, Li MX, Peng XY
BMC Ophthalmol 2022 Apr 22;22(1):187. doi: 10.1186/s12886-022-02397-9. PMID: 35459162Free PMC Article
Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.
Hsieh AR, Huang YC, Yang YF, Lin HJ, Lin JM, Chang YW, Wu CM, Liao WL, Tsai FJ
BMJ Open Diabetes Res Care 2020 Jan;8(1) doi: 10.1136/bmjdrc-2019-000727. PMID: 31958309Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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