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Microvascular complications of diabetes, susceptibility to, 5(MVCD5)

MedGen UID:
436225
•Concept ID:
C2674665
•
Finding
Synonyms: Microvascular complications of diabetes 5; RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO
 
Gene (location): PON1 (7q21.3)
 
Monarch Initiative: MONDO:0012969
OMIM®: 612633

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the PON1 gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta-analysis.
Yin F, Liu J, Fan MX, Zhou XL, Zhang XL
Nephrology (Carlton) 2018 Feb;23(2):107-116. doi: 10.1111/nep.13111. PMID: 28703918
The genetics of diabetic complications.
Ahlqvist E, van Zuydam NR, Groop LC, McCarthy MI
Nat Rev Nephrol 2015 May;11(5):277-87. Epub 2015 Mar 31 doi: 10.1038/nrneph.2015.37. PMID: 25825086
Genome-wide association study of diabetic retinopathy in a Taiwanese population.
Huang YC, Lin JM, Lin HJ, Chen CC, Chen SY, Tsai CH, Tsai FJ
Ophthalmology 2011 Apr;118(4):642-8. Epub 2011 Feb 18 doi: 10.1016/j.ophtha.2010.07.020. PMID: 21310492

Diagnosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta-analysis.
Yin F, Liu J, Fan MX, Zhou XL, Zhang XL
Nephrology (Carlton) 2018 Feb;23(2):107-116. doi: 10.1111/nep.13111. PMID: 28703918
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Prognosis

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients.
Mattishent K, Loke YK
J Diabetes Complications 2016 Jul;30(5):811-8. Epub 2016 Mar 17 doi: 10.1016/j.jdiacomp.2016.03.018. PMID: 27083445
Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.
Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE
Diabetes Metab 2011 Feb;37(1):64-71. Epub 2010 Dec 9 doi: 10.1016/j.diabet.2010.07.010. PMID: 21145773
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Clinical prediction guides

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients.
Mattishent K, Loke YK
J Diabetes Complications 2016 Jul;30(5):811-8. Epub 2016 Mar 17 doi: 10.1016/j.jdiacomp.2016.03.018. PMID: 27083445
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article
The role of antioxidants in the long-term glycation of low density lipoprotein and its Cu2+-catalyzed oxidation.
Sobal G, Menzel J
Free Radic Res 2000 May;32(5):439-49. doi: 10.1080/10715760000300441. PMID: 10766412

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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